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    Ovarian Suppression Evaluating Subcutaneous Leuprolide Acetate in Breast Cancer (OVELIA) (NCT04906395)
    Phase 3
    Tolmar Inc.
    Recruiting
    Last update posted :
    02/24/2025
    Initiation :
    07/01/2021
    Primary completion :
    04/30/2026
    Completion :
    04/30/2026
    HER-2
    |
    HER-2 negative
    |
    tamoxifen • letrozole • anastrozole • exemestane • Eligard (leuprolide acetate)
    (Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer (EVANGELINE) (NCT05607004)
    Phase 2
    Atossa Therapeutics, Inc.
    Recruiting
    Last update posted :
    02/24/2025
    Initiation :
    02/14/2023
    Primary completion :
    02/01/2026
    Completion :
    09/01/2026
    HER-2 • ER
    |
    HER-2 negative
    |
    exemestane • goserelin acetate
    Testing the Anti-Cancer Drug Darolutamide in Patients With Testosterone-driven Salivary Gland Cancers (NCT05669664)
    Phase 2
    National Cancer Institute (NCI)
    Recruiting
    Last update posted :
    02/12/2025
    Initiation :
    07/20/2023
    Primary completion :
    04/11/2027
    Completion :
    04/11/2027
    AR
    |
    AR positive
    |
    Eligard (leuprolide acetate) • Nubeqa (darolutamide) • Viadur (leuprorelin implant)
    A Study of Apalutamide Combined With GnRH Agonist in Participants With Androgen Receptor Positive Salivary Gland Carcinoma (YATAGARASU) (NCT04325828)
    Phase 2
    Janssen Pharmaceutical K.K.
    Active, not recruiting
    Last update posted :
    02/10/2025
    Initiation :
    04/07/2020
    Primary completion :
    06/09/2021
    Completion :
    12/31/2027
    AR
    |
    AR positive
    |
    apalutamide • goserelin acetate
    Study of Quality of Life and Hormone Levels in Premenopausal Participants With Early Breast Cancer Receiving Triptorelin Plus Additional Cancer Treatment (ROSE) (NCT05377684)
    Phase N/A
    Ipsen
    Active, not recruiting
    Last update posted :
    01/31/2025
    Initiation :
    06/09/2022
    Primary completion :
    06/30/2026
    Completion :
    06/30/2026
    HER-2 • BRCA1 • BRCA2 • BRCA
    |
    HR positive • HER-2 negative • HR positive + HER-2 negative • BRCA mutation
    |
    triptorelin
    Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer (S1802) (NCT03678025)
    Phase 3
    SWOG Cancer Research Network
    Recruiting
    Last update posted :
    08/16/2024
    Initiation :
    09/24/2018
    Primary completion :
    04/01/2028
    Completion :
    10/01/2031
    SYP
    |
    docetaxel • abiraterone acetate • prednisone • Eligard (leuprolide acetate) • bicalutamide • triptorelin • goserelin acetate • flutamide • nilutamide • Firmagon (degarelix) • Viadur (leuprorelin implant)
    Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors (NRG-GY033) (NCT06169124)
    Phase 2
    National Cancer Institute (NCI)
    Suspended
    Last update posted :
    06/10/2024
    Initiation :
    02/08/2024
    Primary completion :
    05/31/2027
    Completion :
    05/31/2027
    ER • PGR
    |
    exemestane • Eligard (leuprolide acetate) • Nubeqa (darolutamide) • Viadur (leuprorelin implant)
    Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial (NCT04513717)
    Phase 3
    NRG Oncology
    Recruiting
    Last update posted :
    02/07/2024
    Initiation :
    12/15/2020
    Primary completion :
    12/31/2033
    Completion :
    12/31/2033
    CD4
    |
    abiraterone acetate • bicalutamide • apalutamide • triptorelin • goserelin acetate • flutamide • Firmagon (degarelix) • leuprolide acetate for depot suspension • Suprefact (buserelin acetate) • Yonsa (abiraterone acetate)
    Triptorelin With Either Exemestane or Tamoxifen in Treating Premenopausal Women With Hormone-Responsive Breast Cancer (TEXT) (NCT00066703)
    Phase 3
    ETOP IBCSG Partners Foundation
    Active, not recruiting
    Last update posted :
    01/01/2024
    Initiation :
    11/03/2003
    Primary completion :
    03/11/2011
    Completion :
    12/01/2025
    PGR
    |
    HR positive • PGR positive
    |
    tamoxifen • exemestane • triptorelin
    The Benefits of Continued Use of Ovarian Function Suppression After 5 Years (NCT06050109)
    Phase N/A
    Hongmei Zheng
    Recruiting
    Last update posted :
    10/11/2023
    Initiation :
    09/01/2023
    Primary completion :
    09/01/2028
    Completion :
    09/01/2028
    HER-2
    |
    HER-2 positive • HR positive • HER-2 negative • HR positive + HER-2 negative
    |
    goserelin acetate
    Tracer-Guided Surgery for Recurrent Prostate Cancer (Trace-II) (NCT05555017)
    Phase 2
    The Netherlands Cancer Institute
    Recruiting
    Last update posted :
    10/06/2023
    Initiation :
    02/15/2023
    Primary completion :
    11/01/2024
    Completion :
    11/01/2025
    FOLH1
    |
    FOLH1 expression
    |
    triptorelin
    A Multi-Center Trial of Androgen Suppression With Abiraterone Acetate, Leuprolide, PARP Inhibition and Stereotactic Body Radiotherapy in Prostate Cancer (ASCLEPIuS) (NCT04194554)
    Phase 1/2
    University of Michigan Rogel Cancer Center
    Recruiting
    Last update posted :
    09/14/2023
    Initiation :
    11/06/2020
    Primary completion :
    11/01/2026
    Completion :
    05/01/2027
    DRD
    |
    DDR • DRD
    |
    Zejula (niraparib) • abiraterone acetate • leuprolide acetate for depot suspension
    Study of Neoadjuvant Endocrine Therapy in HR Positive and HER2 Negative Premenopausal Breast Cancer Patients (NCT06009627)
    Phase 2/3
    Tianjin Medical University Cancer Institute and...
    Recruiting
    Last update posted :
    08/24/2023
    Initiation :
    04/11/2023
    Primary completion :
    03/11/2025
    Completion :
    09/11/2026
    HER-2 • ER
    |
    ER positive • HER-2 negative • HER-2 expression • PGR expression
    |
    cyclophosphamide • epirubicin • exemestane • goserelin acetate
    Fertility-sparing Therapy for Patients With Stage IA Endometrial Cancer (NCT05945407)
    Phase N/A
    Peking University People's Hospital
    Recruiting
    Last update posted :
    07/14/2023
    Initiation :
    08/01/2016
    Primary completion :
    12/31/2023
    Completion :
    12/31/2027
    TP53 • PTEN • MLH1 • MSH6 • MSH2
    |
    TP53 expression
    |
    triptorelin • goserelin acetate • megestrol
    Study of Bone Mineral Density in Women With Breast Cancer Treated With Triptorelin and Tamoxifen or Exemestane on Protocol IBCSG 25-02 (TEXT-Bone) (NCT00963417)
    Phase N/A
    ETOP IBCSG Partners Foundation
    Active, not recruiting
    Last update posted :
    05/31/2023
    Initiation :
    08/03/2009
    Primary completion :
    03/11/2011
    Completion :
    12/01/2025
    IGF1 • IGFBP3
    |
    HR positive
    |
    tamoxifen • exemestane • triptorelin
    OFS in Premenopausal Node+ Breast Cancer With Low Genomic Risk (INTERSTELLAR) (NCT05333328)
    Phase 4
    Gangnam Severance Hospital
    Recruiting
    Last update posted :
    02/09/2023
    Initiation :
    02/06/2023
    Primary completion :
    01/01/2028
    Completion :
    01/01/2033
    HER-2 • ER
    |
    HER-2 negative
    |
    tamoxifen • goserelin acetate
    Safety of OFS Combined With AI Endocrine Therapy in Chinese Premenopausal Breast Cancer Patients (SEAT) (NCT02440230)
    Phase 2
    Shanghai Jiao Tong University School of Medicine
    Completed
    Last update posted :
    12/30/2022
    Initiation :
    05/01/2015
    Primary completion :
    12/01/2021
    Completion :
    12/01/2021
    ER • PGR
    |
    anastrozole • exemestane • goserelin acetate
    Neoadjuvant Endocrine Therapy Versus Chemotherapy in Premenopausal Patients With ER+ & HER2- Breast Cancer (NCT02535221)
    Phase 3
    Peking University
    Recruiting
    Last update posted :
    11/29/2021
    Initiation :
    07/29/2015
    Primary completion :
    06/30/2026
    Completion :
    12/31/2026
    HER-2 • PGR
    |
    HER-2 negative • PGR positive
    |
    epirubicin • goserelin acetate
    RWE About QOL and Compliance of Patients With OFS in China (NCT05122377)
    Phase N/A
    Fudan University
    Not yet recruiting
    Last update posted :
    11/16/2021
    Initiation :
    11/01/2021
    Primary completion :
    02/01/2024
    Completion :
    04/01/2024
    HER-2
    |
    HER-2 negative
    |
    goserelin acetate • leuprolide acetate for depot suspension
    Study of Estrogen Levels in Premenopausal Women Who Have Undergone Surgery for Breast Cancer and Are Receiving Triptorelin and Tamoxifen Citrate or Exemestane on Clinical Trial IBCSG 24-02 (SOFT-EST) (NCT00975676)
    Phase N/A
    ETOP IBCSG Partners Foundation
    Completed
    Last update posted :
    10/25/2021
    Initiation :
    11/25/2008
    Primary completion :
    12/01/2016
    Completion :
    12/01/2016
    ER • PGR
    |
    PGR positive
    |
    tamoxifen • exemestane • triptorelin • Soltamox (tamoxifen citrate)
    Efficacy and Safety of Leuprorelin 3M in Premenopausal Women With Hormone Receptor-positive Breast Cancer (NCT04891731)
    Phase N/A
    Sun Yat-Sen Memorial Hospital of Sun Yat-Sen Un...
    Not yet recruiting
    Last update posted :
    05/18/2021
    Initiation :
    05/01/2021
    Primary completion :
    05/01/2023
    Completion :
    09/01/2023
    ER
    |
    PGR expression
    |
    tamoxifen • exemestane • leuprolide acetate for depot suspension
    To Compare ZOLADEX 10.8 mg With ZOLADEX 3.6mg in Chinese Pre-menopausal ER+ HER2- Early Breast Cancer. (LARES) (NCT03658213)
    Phase 3
    AstraZeneca
    Withdrawn
    Last update posted :
    05/10/2021
    Initiation :
    03/31/2020
    Primary completion :
    11/04/2021
    Completion :
    11/04/2021
    HER-2 • ER
    |
    HER-2 negative
    |
    goserelin acetate
    Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow Transplantation (NCT01338987)
    Phase 2
    National Cancer Institute (NCI)
    Completed
    Last update posted :
    03/18/2021
    Initiation :
    04/19/2011
    Primary completion :
    12/01/2017
    Completion :
    11/19/2020
    FLT3 • ABL1 • BCR • KMT2A • HLA-DRB1 • HLA-B • HLA-C
    |
    MLL rearrangement • MLL rearrangement
    |
    cyclophosphamide • methotrexate • fludarabine IV • busulfan • leuprolide acetate for depot suspension • cyclophosphamide intravenous
    Dendritic Cell (DC)-Based Vaccines Loaded With Allogeneic Prostate Cell Lines in Combination With Androgen Ablation in Patients With Prostate Cancer (NCT00970203)
    Phase 2
    Roswell Park Cancer Institute
    Completed
    Last update posted :
    11/03/2020
    Initiation :
    09/01/2009
    Primary completion :
    10/05/2018
    Completion :
    10/05/2019
    CD8 • CD4
    |
    HLA-A2 positive
    |
    goserelin acetate
    S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer (NCT00068601)
    Phase 3
    Southwest Oncology Group
    Completed
    Last update posted :
    12/30/2019
    Initiation :
    10/01/2003
    Primary completion :
    01/01/2014
    Completion :
    09/01/2016
    ER • PGR
    |
    ER negative • PGR negative
    |
    cyclophosphamide • goserelin acetate
    Melanoma Vaccine With Peptides and Leuprolide (NCT00254397)
    Phase 2
    M.D. Anderson Cancer Center
    Completed
    Last update posted :
    10/16/2019
    Initiation :
    11/01/2005
    Primary completion :
    10/01/2012
    Completion :
    10/01/2012
    CD8
    |
    leuprolide acetate for depot suspension
    Estradiol Suppression for the Treatment of Metastatic Breast Cancer in Premenopausal Women (NCT00186121)
    Phase 2
    Stanford University
    Completed
    Last update posted :
    10/07/2019
    Initiation :
    10/01/2000
    Primary completion :
    05/01/2013
    Completion :
    06/01/2013
    PGR
    |
    anastrozole • goserelin acetate
    Effect of Triptorelin (Decapeptyl®) 22.5 mg on Two Biomarkers in Patients With Advanced Prostate Cancer (Triptocare) (NCT01020448)
    Phase 3
    Ipsen
    Completed
    Last update posted :
    01/30/2019
    Initiation :
    11/01/2009
    Primary completion :
    11/01/2011
    Completion :
    06/01/2013
    ERG • TMPRSS2 • PCA3
    |
    triptorelin
    Study to Compare Zoladex™ 10.8 mg With Zoladex 3.6 mg in Pre-menopausal Women With Breast Cancer (NCT01073865)
    Phase 3
    AstraZeneca
    Completed
    Last update posted :
    12/12/2018
    Initiation :
    02/26/2010
    Primary completion :
    09/19/2012
    Completion :
    11/20/2017
    ER
    |
    ER positive
    |
    tamoxifen • goserelin acetate
    Selective Treatment According to Molecular Subtype of Prostate Cancer (STAMP) (NCT03696186)
    Phase 2
    Tianjin Medical University Second Hospital
    Recruiting
    Last update posted :
    10/09/2018
    Initiation :
    08/01/2018
    Primary completion :
    08/01/2022
    Completion :
    08/01/2023
    BRAF
    |
    carboplatin • docetaxel • goserelin acetate
    Neoadjuvant Goserelin for Triple Negative Breast Cancer (NeoGONT) (NCT03444025)
    Phase 2
    Kasr El Aini Hospital
    Not yet recruiting
    Last update posted :
    02/23/2018
    Initiation :
    03/01/2018
    Primary completion :
    03/01/2021
    Completion :
    03/01/2023
    HER-2 • PGR • AR
    |
    HER-2 negative • AR positive • PGR negative
    |
    doxorubicin hydrochloride • cyclophosphamide • goserelin acetate
    Gonadotropin-Releasing Hormone Agonist for the Preservation of Ovarian Function During Chemotherapy in Premenopausal Breast Cancer (POF) (NCT02483767)
    Phase 3
    Peking Union Medical College Hospital
    Completed
    Last update posted :
    10/17/2017
    Initiation :
    06/01/2015
    Primary completion :
    11/01/2016
    Completion :
    11/01/2016
    HER-2
    |
    HER-2 overexpression
    |
    paclitaxel • cyclophosphamide • goserelin acetate
    Simultaneous Versus Sequential Use of Adjuvant Chemotherapy and GnRHa in Treating ER+,Premenopausal Breast Cancer (NCT01712893)
    Phase 3
    Fudan University
    Completed
    Last update posted :
    08/25/2017
    Initiation :
    06/01/2009
    Primary completion :
    08/01/2017
    Completion :
    08/01/2017
    ER • PGR
    |
    HR positive • ER negative • PGR positive • PGR expression
    |
    tamoxifen • goserelin acetate
    The Predictive Value of TMPRSS2-ERG Fusion in High Risk Prostate Cancer Patient (NCT02588404)
    Phase N/A
    Sir Mortimer B. Davis - Jewish General Hospital
    Not yet recruiting
    Last update posted :
    07/28/2016
    Initiation :
    12/01/2016
    Primary completion :
    01/01/2030
    ERG • TMPRSS2
    |
    TMPRSS2-ERG fusion
    |
    Eligard (leuprolide acetate) • triptorelin • goserelin acetate • leuprolide acetate for depot suspension
    Exemestane Plus Goserelin in Treating Premenopausal Women With Metastatic Breast Cancer (NCT00010010)
    Phase 2
    NYU Langone Health
    Completed
    Last update posted :
    03/11/2016
    Initiation :
    06/01/2000
    Primary completion :
    05/01/2001
    PGR
    |
    ER positive + PGR positive • PGR positive
    |
    exemestane • goserelin acetate
    Administration During Chemotherapy to Reduce Ovarian Failure Following Chemotherapy in Early Stage, Hormone-Receptor Negative Breast Cancer (NCT01530607)
    Phase 3
    King Faisal Specialist Hospital & Research Center
    Completed
    Last update posted :
    02/25/2016
    Initiation :
    11/01/2009
    Primary completion :
    11/01/2012
    Completion :
    11/01/2012
    PGR
    |
    ER negative • PGR negative
    |
    cyclophosphamide • goserelin acetate
    A Phase 3 Comparative Study of TAP-144-SR(6M) in Postoperative and Hormone Therapy-naïve Patients With Premenopausal Breast Cancer (NCT01546649)
    Phase 3
    Takeda
    Completed
    Last update posted :
    11/26/2015
    Initiation :
    04/01/2012
    Primary completion :
    12/01/2014
    Completion :
    12/01/2014
    HER-2 • ER • PGR
    |
    ER positive • HER-2 negative
    |
    leuprolide acetate for depot suspension