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    BIOMARKER:

    GNAQ R183Q

    i
    Other names: GNAQ, G Protein Subunit Alpha Q, Guanine Nucleotide Binding Protein (G Protein) Q Polypeptide, Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha, Guanine Nucleotide-Binding Protein Alpha-Q, GAQ, Epididymis Secretory Sperm Binding Protein, G-ALPHA-Q, CMC1, SWS
    Entrez ID:
    2776
    Related biomarkers:
    Mutation
    11ms
    Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis. (PubMed, Acta Neuropathol Commun)
    NRAS mutation was found only in the abdominal tumor and was thought to be responsible for malignant progression in the present case. Multiregional comprehensive genetic analysis may lead to discovering novel driver mutations associated with tumorigenesis and targeted therapy.
    Journal
    |
    NRAS (Neuroblastoma RAS viral oncogene homolog) • GNAQ (G Protein Subunit Alpha Q)
    |
    NRAS mutation • GNAQ mutation • NRAS G12 • GNAQ R183Q • NRAS G12V
    over2years
    Clinicopathologic features and survival outcomes of ocular melanoma: a series of 31 cases from a tertiary university hospital. (PubMed, J Pathol Transl Med)
    Patients with uveal melanoma presented with an advanced pathological tumor stage compared to those with conjunctival melanoma (p = .019). This study confirmed the presence of tumor-infiltrating lymphocytes as a favorable factor in conjunctival melanoma and conjunctival and lens involvement as unfavorable prognostic factors in uveal melanoma for overall survival, respectively.
    Journal
    |
    BRAF (B-raf proto-oncogene) • GNAQ (G Protein Subunit Alpha Q)
    |
    BRAF mutation • GNAQ R183Q