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4ms
Predictive Biomarkers for Response to TGF- β Inhibition in Resensitizing Chemo(radiated) Esophageal Adenocarcinoma. (PubMed, Pharmacol Res)
TGF-β inhibitors fresolimumab and A83-01 were employed to inhibit EMT, and mesenchymal markers were quantified via flow cytometry to assess efficacy...Our findings reveal a distinct gene expression pattern associated with the response to TGF-β inhibition in chemo(radiated) EAC. The identified DEGs and predictive markers may assist patient selection in clinical studies investigating TGF-β targeting.
Journal
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HER-2 (Human epidermal growth factor receptor 2) • TGFB1 (Transforming Growth Factor Beta 1)
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fresolimumab (GC 1008)
1year
In-silico prediction of TGF-β1 non-synonymous variants and their impact on binding affinity to Fresolimumab. (PubMed, J Biomol Struct Dyn)
Among them, the E35D variant significantly destabilized the TGF-β1 protein structure, resulting in rearrangement in the binding site and affecting the interactions with the Fresolimumab. This study identified four variants that can affect the TGF-β1 protein structure and result in functional consequences such as impaired response to Fresolimumab.Communicated by Ramaswamy H. Sarma.
Journal
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TGFB1 (Transforming Growth Factor Beta 1)
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fresolimumab (GC 1008)
over2years
Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses. (PubMed, J Immunother Cancer)
BA more effectively blocks TGF-β by targeting TGF-β trap to the tumor via PD-L1 binding. Such colocalized targeting elicits distinct and superior antitumor responses relative to single agent combination therapy.
Journal • PD(L)-1 Biomarker • IO biomarker
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TGFB1 (Transforming Growth Factor Beta 1)
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PD-L1 expression
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bintrafusp alfa (M7824) • fresolimumab (GC 1008)