ER negative

These three types of immune desserts can coexist with each other and with immune hot regions in the same tumor. The coordinated interplay of NOS2 and COX2 indicates that targeting both these enzymes provides an effective treatment strategy that is supported by ongoing clinical trials demonstrating improved clinical outcomes in patients who have otherwise exhausted treatment options.

nSEP was not associated with breast cancer overall, but associations with higher disadvantage varied with ER status. Neighborhood-level socioeconomic context may differentially influence breast cancer risk by tumor subtype.

P3, N=782, Active, not recruiting, NRG Oncology | Trial primary completion date: Oct 2026 --> Dec 2025

PORT for YWBC was associated with elevated risks of SPMs. The risk of PORT-related SPMs increased with a longer follow-up period, suggesting the need for long-term surveillance of these patients.

Fine-mapping results vary across methods, and no single approach is sufficient. The choice of L strongly influences results, and combining analytical approaches with functional validation can improve causal variant identification.

However, the absence of lymphovascular invasion remains a significant positive prognostic factor. These observations support further investigation into the integration of proliferation markers into multivariable predictive models to improve response stratification in breast cancer.

Notably, this study provides the first transcriptomic and stem-associated characterization of αZAL in ER-positive breast cancer cells, revealing a robust estrogenic mode of action. This work provides mechanistic insight into how environmental EDCs may influence ER-positive breast cancer biology.

Regardless of all breast cancer or TNBC patients, no clear relationship was observed between patient prognosis and CAV-1 expression. We suggest that CAV-1 expression is significantly upregulated in TNBC, with potential clinical value for distinguishing between TNBC and non-TNBC.

Comprehensive sensitivity analyses supported these findings. This study provides further evidence that GDM may be a risk factor for BC, particularly the ER-negative subtype, suggesting that GDM may be incorporated into personalized risk assessment models.

Diagnostic physicians should note that linear calcifications in the mass pointing toward non-nipple directions should be an important diagnostic clue for SPC of the breast. Diagnostic physicians should further note that many small cystic components in the mass are also important diagnostic image findings for SPC of the breast.

Next-generation sequencing (NGS) analysis revealed copy number loss of SMARCB1 and a novel GSTT1::IGLC7 fusion in the tumor, while no other gene rearrangements, including those involving EWSR1, NR4A3, or FUS, were detected. This finding not only expands the molecular genetic spectrum of MELTVR but also provides valuable insight for future investigations into its pathogenesis, biological behavior, and refinement of clinical diagnostic and therapeutic strategies for this rare tumor.

P3, N=246, Recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Active, not recruiting --> Recruiting | Trial completion date: Mar 2031 --> Jun 2029 | Trial primary completion date: Sep 2030 --> Dec 2028