^
    3ms
    Anti-Lung Cancer Effects and Related Mechanisms of α-Caryophyllene In Vitro and In Vivo. (PubMed, Food Sci Nutr)
    In antitumor activity in vitro, α-caryophyllene exhibited obvious selective cytotoxicity, and its cytotoxicity against lung cancer A549 cells (IC50 = 22.94 ± 0.56) was superior to the elemene injection (EI, positive control), while its toxicity against normal cell lines was lower (MRC-5: IC50 = 76.66 ± 2.60 μg/mL, L929: IC50 = 44.04 ± 0.72 μg/mL)...In antitumor activity in vivo, α-caryophyllene effectively suppressed transplanted tumor growth by inducing apoptosis of transplanted tumor cells and was superior to the positive control EI. Therefore, α-caryophyllene has outstanding anticancer properties in vitro and in vivo, showing great potential to become a new anticancer drug in the pharmaceutical field.
    Preclinical • Journal
    |
    BCL2 (B-cell CLL/lymphoma 2) • CDK4 (Cyclin-dependent kinase 4) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • MMP2 (Matrix metallopeptidase 2) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CCND3 (Cyclin D3) • CDK2 (Cyclin-dependent kinase 2) • CASP9 (Caspase 9) • CDH2 (Cadherin 2) • CCNE2 (Cyclin E2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
    |
    elemene injection
    11ms
    Elemene Injection Suppresses Pancreatic Cancer Progress through Regulating Cell Adhesion: A Research Based upon Network Pharmacology and Verification Test. (PubMed, Curr Med Chem)
    The findings of the current study emphasized that elemene injection might control cell attachment, decrease metastasis, and suppresses pancreatic cancer progress. FN1 might be a therapeutic target for pancreatic cancer.
    Journal
    |
    FN1 (Fibronectin 1)
    |
    elemene injection
    11ms
    β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the MAPK and STAT3 signaling pathways. (PubMed, J Ethnopharmacol)
    This study demonstrates that the inhibitory effect of β-ELE on endometriosis by inducing ferroptosis in vitro and in vivo. Our results revealed that β-ELE exerts anti-endometriosis effects by inducing ferroptosis via the MAPK and STAT3 signaling pathways.
    Journal
    |
    GPX4 (Glutathione Peroxidase 4) • FTL (Ferritin Light Chain) • MAPK14 (Mitogen-Activated Protein Kinase 14)
    |
    elemene injection
    over1year
    Elemene Injection Overcomes Paclitaxel Resistance in Breast Cancer through AR/RUNX1 Signal: Network Pharmacology and Experimental Validation. (PubMed, Curr Pharm Des)
    Elemene Injection (EI) application has exhibited a significant capability to mitigate PTX resistance in BC, which has been achieved through targeted suppression of the AR/RUNX1 axis, revealing a key strategy to overcome chemotherapeutic resistance.
    Journal
    |
    RUNX1 (RUNX Family Transcription Factor 1) • KLF4 (Kruppel-like factor 4) • POU5F1 (POU Class 5 Homeobox 1)
    |
    paclitaxel • elemene injection
    over3years
    Effect of Network-Based Positive Psychological Nursing Model Combined With Elemene Injection on Negative Emotions, Immune Function and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy in the Era of Big Data. (PubMed, Front Public Health)
    Compared with CG, EG had notably higher immune function indexes (P < 0.001), lower serum VEGF and MMP-2 levels (P < 0.001), lower HAMA and HAMD scores (P < 0.05), and higher scores of PTGI, physiological function, psychological function, social function and physical function (P < 0.001). The network-based positive psychological nursing model combined with elemene injection is a reliable method to enhance the immune function and QOL of LC patients undergoing chemotherapy and alleviate their negative emotions, which has a high clinical application value.
    Retrospective data • Journal • HEOR
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    MMP2 (Matrix metallopeptidase 2)
    |
    elemene injection
    over4years
    Beta-Elemene Reduces the Malignancy of Non-Small Cell Lung Cancer by Enhancing C3orf21 Expression. (PubMed, Front Oncol)
    Such data indicated that beta-elemene treatment attenuated the malignancy of NSCLC cells by up-regulating C3orf21 expression. Our findings may provide new mechanisms underlying the pharmacological action of beta-elemene.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • NOTCH1 (Notch 1) • CCND1 (Cyclin D1) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9)
    |
    CCND1 expression • NOTCH1 expression
    |
    elemene injection