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DRUG:

elemene injection

Associations
Trials
Company:
BeiJing Yijiayi Medicine
Drug class:
Apoptosis stimulant
Associations
Trials
5ms
Elemene Injection Overcomes Paclitaxel Resistance in Breast Cancer through AR/RUNX1 Signal: Network Pharmacology and Experimental Validation. (PubMed, Curr Pharm Des)
Elemene Injection (EI) application has exhibited a significant capability to mitigate PTX resistance in BC, which has been achieved through targeted suppression of the AR/RUNX1 axis, revealing a key strategy to overcome chemotherapeutic resistance.
Journal
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RUNX1 (RUNX Family Transcription Factor 1) • KLF4 (Kruppel-like factor 4) • POU5F1 (POU Class 5 Homeobox 1)
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paclitaxel • elemene injection
over2years
Effect of Network-Based Positive Psychological Nursing Model Combined With Elemene Injection on Negative Emotions, Immune Function and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy in the Era of Big Data. (PubMed, Front Public Health)
Compared with CG, EG had notably higher immune function indexes (P < 0.001), lower serum VEGF and MMP-2 levels (P < 0.001), lower HAMA and HAMD scores (P < 0.05), and higher scores of PTGI, physiological function, psychological function, social function and physical function (P < 0.001). The network-based positive psychological nursing model combined with elemene injection is a reliable method to enhance the immune function and QOL of LC patients undergoing chemotherapy and alleviate their negative emotions, which has a high clinical application value.
Retrospective data • Journal • HEOR
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MMP2 (Matrix metallopeptidase 2)
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elemene injection
over3years
Beta-Elemene Reduces the Malignancy of Non-Small Cell Lung Cancer by Enhancing C3orf21 Expression. (PubMed, Front Oncol)
Such data indicated that beta-elemene treatment attenuated the malignancy of NSCLC cells by up-regulating C3orf21 expression. Our findings may provide new mechanisms underlying the pharmacological action of beta-elemene.
Journal
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • NOTCH1 (Notch 1) • CCND1 (Cyclin D1) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9)
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CCND1 expression • NOTCH1 expression
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elemene injection