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    BIOMARKER:

    DDB1 overexpression

    i
    Other names: DDB1, Damage Specific DNA Binding Protein 1, Xeroderma Pigmentosum Group E-Complementing Protein, UV-Damaged DNA-Binding Protein 1, UV-Damaged DNA-Binding Factor, DNA Damage-Binding Protein 1, DNA Damage-Binding Protein A, HBV X-Associated Protein 1, XPE-Binding Factor, DDB P127 Subunit, UV-DDB 1, XPE-BF , XAP-1, XAP1, Damage-Specific DNA Binding Protein 1, 127kDa, Damage-Specific DNA Binding Protein 1 (127kD), Damage-Specific DNA-Binding Protein 1, UV-DDB1, DDBA, XPCE, DDBa, XPCe, XPE
    Entrez ID:
    1642
    2ms
    VEGFR affects miR-3200-3p-mediated regulatory T cell senescence in tumour-derived exosomes in non-small cell lung cancer. (PubMed, Funct Integr Genomics)
    In conclusion, inhibition of VEGFR2 expression in tumour cells promotes the expression of miR-3200-3p in exosomes secreted by tumour cells. miR-3200-3p enters the TME through exosomes and acts on DDB1 in Treg cells to promote senescence of Treg cells to inhibit tumour progression.
    Journal
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • GSTP1 (Glutathione S-transferase pi 1) • DDB1 (Damage Specific DNA Binding Protein 1) • MIR3200 (MicroRNA 3200) • MMP3 (Matrix metallopeptidase 3)
    |
    KDR expression • DDB1 overexpression
    3ms
    PRPF19 functions in DNA damage repair and gemcitabine sensitivity via regulating DDB1 in bladder cancer cells. (PubMed, Cytotechnology)
    It promoted cell growth and DNA damage repair, and decreased gemcitabine sensitivity via positively regulating DDB1 expression. The online version contains supplementary material available at 10.1007/s10616-023-00599-7.
    Journal • BRCA Biomarker
    |
    BRCA1 (Breast cancer 1, early onset) • DDB1 (Damage Specific DNA Binding Protein 1)
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    BRCA1 expression • DDB1 overexpression
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    gemcitabine
    2years
    DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression. (PubMed, Cancer Sci)
    Overexpression of DDB1 significantly increased PERP polyubiquitination, suggesting that CRL4 E3 ligase targets PERP for ubiquitination and proteasomal degradation. In conclusion, DCAF13 and the downstream effector PERP occupy key roles in breast cancer proliferation and potentially serve as prognostics and therapeutic targets.
    Journal
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    DDB1 (Damage Specific DNA Binding Protein 1) • IL17RB (Interleukin 17 Receptor B)
    |
    DDB1 overexpression