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BIOMARKER:

CXCL8 elevation

i
Other names: CXCL8, 3-10C, AMCF-I, b-ENAP, GCP-1, GCP1, IL-8, IL8, K60, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, SCYB8, TSG-1, Chemokine (C-X-C motif) ligand 8
Entrez ID:
Related biomarkers:
4d
Down-regulation of A20 mRNA expression in peripheral blood mononuclear cells from MDS patients. (PubMed, Hematology)
We did not find a significant correlation between A20 mRNA and clinical characteristics (age, sex, concentration of hemoglobin, neutrophils count, platelets count, percent of blasts, and WHO classification) of the patients, nor between A20 mRNA and plasma cytokines (data not shown). Our study found down-regulated of A20 and increased levels of pro-inflammatory cytokines in the peripheral blood of MDS patients, providing further evidence for the activation of inflammatory signals in MDS.
Journal
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TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation
8d
Prognostic value of inflammation and immune-related gene NOD2 in clear cell renal cell carcinoma. (PubMed, Hum Cell)
Furthermore, results showed that miR-20b-5p targeted NOD2 to alleviate NOD2-mediated IL-8 secretion. In conclusion, NOD2 is a potential prognostic biomarker for ccRCC and the miR-20b-5p/NOD2/IL-8 axis may regulate inflammation- and immune-mediated tumorigenesis in ccRCC.
Journal
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CD8 (cluster of differentiation 8) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD4 (CD4 Molecule) • NLRC5 (NLR Family CARD Domain Containing 5) • MIR20B (MicroRNA 20b) • PYCARD (PYD And CARD Domain Containing)
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CXCL8 elevation
15d
Carbon-Coated Iron Oxide Nanoparticles Promote Reductive Stress-Mediated Cytotoxic Autophagy in Drug-Induced Senescent Breast Cancer Cells. (PubMed, ACS Appl Mater Interfaces)
Fe3O4@aC caused a decrease in reactive oxygen species (ROS) production and an increase in the levels of antioxidant proteins FOXO3a, SOD1, and GPX4 that was accompanied by elevated levels of cell cycle inhibitors (p21, p27, and p57), proinflammatory (NFκB, IL-6, and IL-8) and autophagic (BECN1, LC3B) markers, nucleolar stress, and subsequent apoptotic cell death in etoposide-stimulated senescent breast cancer cells. Fe3O4@aC also promoted reductive stress-mediated cytotoxicity in nonsenescent breast cancer cells. We postulate that Fe3O4 NPs, in addition to their well-established hyperthermia and oxidative stress-mediated anticancer effects, can also be considered, if modified using amorphous carbon coating with reductive activity, as stimulators of reductive stress and cytotoxic effects in both senescent and nonsenescent breast cancer cells with different gene mutation statuses.
Journal
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IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • GPX4 (Glutathione Peroxidase 4) • FOXO3 (Forkhead box O3) • BECN1 (Beclin 1)
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CXCL8 elevation
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etoposide IV
28d
Plasma-derived from human umbilical cord blood restores ovarian function and improves serum reproductive hormones levels in mice with premature ovarian insufficiency (POI) through cytokines and growth factors. (PubMed, Mol Reprod Dev)
Our findings suggested that CBP-secreted cytokines and growth factors could be restored POI ovarian function, enhanced serum reproductive hormones and rescued follicular development in vivo. These findings further support the potential of CBP as a promising strategy in clinical applications for POI related infertility.
Preclinical • Journal
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IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IGF1 (Insulin-like growth factor 1) • IL2 (Interleukin 2) • TGFB1 (Transforming Growth Factor Beta 1) • IL17A (Interleukin 17A) • IL4 (Interleukin 4)
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CXCL8 elevation
29d
Clostridium perfringens α toxin damages the immune function, antioxidant capacity and intestinal health and induces PLCγ1/AMPK/mTOR pathway-mediated autophagy in broiler chickens. (PubMed, Heliyon)
In conclusion, C. perfringens α toxin challenge decreased body weight gain, impaired immune function, antioxidant capacity and intestinal health, and induced PLCγ1/AMPK/mTOR pathway-mediated autophagy. The recommended intraperitoneal injection dose for moderate injury was 0.1 U/kg of body weight and the recommended sampling time was 3 h p.i. in broiler chickens.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CLDN1 (Claudin 1) • ATG5 (Autophagy Related 5) • IL1B (Interleukin 1, beta) • TJP1 (Tight Junction Protein 1) • CAT (Catalase) • CLDN3 (Claudin 3) • OCLN (Occludin)
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CXCL8 elevation • CXCL8 expression • ATG5 expression
30d
IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer. (PubMed, J Cell Mol Med)
In summary, our study identified CD248 activates the NF-κB axis, which, consecutively induces the CAFs-based secretion of IL-8, which promotes NSCLC chemoresistance. This report highlights a potential new approach to enhancing the chemotherapeutic potential of NSCLC-treating cisplatin.
Journal
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ABCB1 (ATP Binding Cassette Subfamily B Member 1) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation • CXCL8 expression
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cisplatin
1m
A preliminary mechanistic exploration of the effect of leptin on the docetaxel sensitivity of MDA‑MB‑231 triple‑negative breast cancer cells. (PubMed, Mol Clin Oncol)
The expression of IL-8 was notably elevated in the group treated with leptin-activated TAMs compared with that in the other groups. The neutralization of IL-8 resulted in a significant reduction in the invasive migration of MDA-MB-231 cells compared with that in the non-neutralized group.
Journal
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CXCL8 (Chemokine (C-X-C motif) ligand 8) • LEP (Leptin)
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CXCL8 elevation • CXCL8 expression
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docetaxel
1m
Implication of M2 macrophage on NLRP3 inflammasome signaling in mediating the neuroprotective effect of Canagliflozin against methotrexate-induced cognitive impairment. (PubMed, Int Immunopharmacol)
(3) received MTX (75 mg/kg, i.v.) on day 8 and 15, then they were injected with four i.p. injections of leucovorin (LCV): the first dose was 6 mg/ kg after 18 h, and the remaining doses were 3 mg/kg after 26, 42, and 50 h of MTX administration. CANA treatment restored cognitive ability, reduced MTX-induced oxidative stress and neuroinflammation via attenuation of TLR4/NF-κB/NLRP3 signaling, and rebalanced macrophage polarization by promoting the M2 phenotype. Hence, targeting molecular mechanisms manipulating macrophage polarization may offer novel neuroprotective strategies for preventing or treating MTX-induced immune modulation and its detrimental sequel.
Journal
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CXCL8 (Chemokine (C-X-C motif) ligand 8) • TLR4 (Toll Like Receptor 4) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3)
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CXCL8 elevation
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methotrexate • leucovorin calcium
2ms
Anticancer effect of propranolol on diethylnitrosamine-induced hepatocellular carcinoma rat model. (PubMed, Fundam Clin Pharmacol)
Propranolol exhibited an anticancer effect and thus can be considered as a promising treatment for HCC. Blocking of PD-1/PD-L1 and LAG-3 signals participated in the anti-tumor effect of propranolol on HCC.
Preclinical • Journal • PD(L)-1 Biomarker • IO biomarker
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CD8 (cluster of differentiation 8) • LAG3 (Lymphocyte Activating 3) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • AFP (Alpha-fetoprotein) • IL10 (Interleukin 10) • TGFB1 (Transforming Growth Factor Beta 1)
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CXCL8 elevation
2ms
Tumor cell-derived LC3Bextracellular vesicles mediate the crosstalk between tumor microenvironment and immunotherapy efficacy in hepatocellular carcinoma via the HSP90α-IL-6/IL-8 signaling axis. (PubMed, Clin Immunol)
Our data suggest that liver cancer-derived LC3B EVs promote a pro-oncogenic inflammatory microenvironment by carrying membrane-bound HSP90α. Targeting HSP90α on the LC3B EVs, IL-6, or IL-8 may synergize with anti-PD-1 treatment to enhance the CD8 T-cell functions, which may provide novel combination strategies in the clinic for the treatment of liver cancer.
Journal • PD(L)-1 Biomarker • IO biomarker • Tumor cell
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CD8 (cluster of differentiation 8) • IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
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CXCL8 elevation • CXCL8 expression • IL6 expression
2ms
Targeting STAT3 in tumor-associated antigen-presenting cells as a strategy for kidney and bladder cancer immunotherapy. (PubMed, Front Immunol)
To better understand immune alterations associated with ICB resistance, we assessed blood biomarkers in renal cancer patients classified as responders or non-responders to first line nivolumab/ipilimumab immunotherapy...To assess whether STAT3 inhibition within these cell subsets can promote antitumor immune responses and/or enhance sensitivity to ICB in vivo, we used an original antisense oligonucleotide (ASO) strategy for myeloid-cell selective STAT3 knockdown (CpG-STAT3ASO)...Therapeutic efficacy correlated with activation of dendritic cells (DCs) and M1 macrophages in the tumor microenvironment, reduced percentages of regulatory T cells (Tregs) and the expansion of CD8 T cells in both tumor models. Our study underscores the potential of using myeloid-cell targeted CpG-STAT3 inhibitors for genitourinary cancer therapy to disrupt tolerogenic signaling, restore immune cell activity and sensitivity to immune checkpoint inhibitors and/or T cell-based immunotherapies.
Journal • PD(L)-1 Biomarker • IO biomarker
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CD8 (cluster of differentiation 8) • IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IL10 (Interleukin 10) • IL1R1 (Interleukin 1 receptor, type I)
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CXCL8 elevation
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Opdivo (nivolumab) • Yervoy (ipilimumab) • DUET-101
2ms
Despite Recovery from Necrotizing Enterocolitis Infants Retain a Hyperinflammatory Response to Injury. (PubMed, J Inflamm Res)
This tendency towards an increased hyperinflammatory state may be correlated with an infant's proclivity to develop NEC and demonstrates the significance of a second hit on this tissue creating a heightened inflammatory response. This could be correlated with the impact and trajectory of an illness post recovery from NEC.
Journal
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TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation
2ms
Preoperative IL-8 levels as prognostic indicators of overall survival: an extended follow-up in a prospective cohort with colorectal liver metastases. (PubMed, BMC Cancer)
This study establishes preoperative IL-8 levels as a potential prognostic biomarker for overall survival in patients undergoing curative liver resection for CRC liver metastases. This study underscores the importance of incorporating IL-8 and other biomarkers into clinical decision-making, facilitating improved patient stratification and tailored treatment approaches. Further research and validation studies are needed to solidify the clinical utility of IL-8 as a prognostic marker.
Retrospective data • Journal
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CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation
2ms
Pancreatectomy Induces Cancer-Promoting Neutrophil Extracellular Traps. (PubMed, Ann Surg Oncol)
Pancreatectomy induces cancer-promoting NET formation. The minimally invasive robotic approach may induce fewer NETs, although the current analysis was limited by selection bias. Pancreatic leak resulted in increased NETs. Further study into the potential for NET inhibition during the perioperative period is warranted.
Journal
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IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation
3ms
Possible correlation between serum interleukin-8 levels and the activity of myositis in anti-NXP2 antibody-positive dermatomyositis. (PubMed, Immunol Med)
Serum IL-8 levels were significantly elevated in anti-NXP2 or anti-TIF1γ antibody-positive DM patients with myositis but not ILD, than healthy controls. It was suggested that serum levels of IL-8 correlate with the activity of myositis in DM including anti-NXP2 antibody-positive DM.
Journal
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IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation
3ms
Gilaburu (Viburnum opulus L.) fruit extract has potential therapeutic and prophylactic role in a rat model of acetic acid-induced oxidant colonic damage. (PubMed, J Ethnopharmacol)
Gilaburu shows both anti-inflammatory and antioxidant effects against AA-induced colonic damage by suppressing neutrophil infiltration, regulating inflammatory mediators, inhibiting reactive species production, lipid peroxidation, and apoptosis, conserving endogenous antioxidant glutathione, and ameliorating oxidative DNA damage. Since the current ulcerative colitis drugs display limited benefits and adverse side effects, potential therapeutic and/or prophylactic role of gilaburu can be evaluated in ulcerative colitis.
Preclinical • Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • TGFB1 (Transforming Growth Factor Beta 1) • MMP9 (Matrix metallopeptidase 9) • IL1B (Interleukin 1, beta) • MPO (Myeloperoxidase) • SMAD3 (SMAD Family Member 3)
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CXCL8 elevation
4ms
Investigation into actions of Xiebai and Zengye decoction on cough sensitivity, airway inflammation and gut microbiota in the rat model of post-infectious cough. (PubMed, Heliyon)
Using a random number table, the rats that were successfully modelled were assigned to the PIC, XBZY group (14.8 g/kg/d), and montelukast sodium treatment (MAS) group (1 mg/kg/d)...In conclusion, XBZY decoction significantly reduced cough sensitivity and airway inflammation in PIC rats while ameliorating stool dryness and colonic inflammation. The protective effects of XBZY decoction could be linked to modulat gut microbiota in PIC rats, and regulat SCFAs contents in PIC rats, while the regulator mechanisms of XBZY decoction in gut microbiota still requires further in-depth investigation.
Preclinical • Journal
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TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation
4ms
New treatment of pyoderma gangrenosum and hidradenitis suppurativa: A review. (PubMed, J Dermatol)
When resistance to biologics emerges, a combined approach targeting multiple overactive cytokines with immunosuppressants, for example cyclosporine and Janus kinase inhibitors, could be an option. In the current review, we explore recent therapeutic developments for PG and HS.
Review • Journal
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TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL17A (Interleukin 17A) • IL23A (Interleukin 23 Subunit Alpha)
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CXCL8 elevation
4ms
Comparison of the effects of moxibustion and acupuncture of combined "Biao-Ben" acupoints on intestinal sensitivity and autonomic nervous system function in rats with diarrhea-predominant irritable bowel syndrome. (PubMed, Zhen Ci Yan Jiu)
Moxibustion of combined "Biao-Ben" acupoints is more effective in regulating HRV and serum IL-6, IL-8, and TNF-α contents in the IBS-D rat model. Based on the combined "Biao-Ben" acupoints method, moxibustion has better therapeutic effects on IBS-D than acupuncture.
Preclinical • Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation
4ms
Characterizing the Immune Environment in Peritoneal Carcinomatosis: Insights for Novel Immunotherapy Strategies. (PubMed, Ann Surg Oncol)
The peritoneal immune microenvironment in carcinomatosis favors innate immunity, presenting a challenging environment for effective antitumor response. High levels of proinflammatory mediators suggest potential targets for intervention, such as the IL-6 axis, FGF2, IL-8, and CCL2; these could be explored as potential mitigators of malignant ascites and enhance anti-tumor immune responses. These findings provide valuable insights for developing immunotherapy strategies and improving outcomes in patients with peritoneal carcinomatosis.
Journal • IO biomarker
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IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • FGF2 (Fibroblast Growth Factor 2) • CCL2 (Chemokine (C-C motif) ligand 2)
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CXCL8 elevation
4ms
Cytokine Levels in Neonates: Unveiling the Impact of Perinatal Inflammation on Prematurity. (PubMed, Am J Perinatol)
· There is a direct association between cytokine levels and prematurity. · Knowledge of the variation of cytokines in newborns enhances personalized interventions. · Cytokine levels are early associated with gestational age.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL10 (Interleukin 10) • TGFB1 (Transforming Growth Factor Beta 1)
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IL6 elevation • CXCL8 elevation
5ms
The Correlation Between Cardiac Oxidative Stress and Inflammatory Cytokine Response Following Myocardial Infarction. (PubMed, Clin Appl Thromb Hemost)
This study evaluated the severity of myocardial infarction using indicators such as CO and CI. This study found a significant correlation between cardiac oxidative stress and inflammatory cytokines after myocardial infarction, suggesting their potential as predictors of myocardial infarction severity.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CAT (Catalase) • CRP (C-reactive protein)
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CXCL8 elevation
5ms
Serum alpha 1-acid glycoprotein and interleukin-8 elevations in felines with localized and metastatic tumors. (PubMed, Am J Vet Res)
While AGP is a more prominent biomarker than SAA in cats with tumors, a significant elevation of AGP and SAA levels in association with metastasis and specific tumor types could not be identified. Alternatively, further investigation is warranted to evaluate the potential significance of IL-8 in tumor progression and metastasis.
Journal • Metastases
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CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation
5ms
A Long-Term Analysis of Lenalidomide and Rituximab (R2) for the Treatment of Chronic Lymphocytic Leukemia (ASH 2023)
Only 2 pts developed VTE during active R2 and both were not taking prophylactic aspirin. In this long-term pooled f/u analysis of CLL pts, we found that R2 provided high ORR, modest PFS and OS benefit, and tolerable long-term toxicities. The ORR of R2 in this study (82.3%) compares favorably to ORR of R monotherapy in previous studies (51%, Hainsworth et al, JCO 2003). The absence of secondary myeloid neoplasms suggests that len may not substantially increase cumulative secondary malignancy risk—the cumulative cutaneous neoplasm incidence may reflect elevated baseline risk in CLL pts.
PD(L)-1 Biomarker • IO biomarker
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IGH (Immunoglobulin Heavy Locus) • IKZF1 (IKAROS Family Zinc Finger 1) • CRBN (Cereblon)
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Chr del(11q) • IGH mutation • CXCL8 elevation • TS 12
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Rituxan (rituximab) • lenalidomide • aspirin
5ms
Safety, Pharmacodynamic, and Anti-Tumor Activity of SL-172154 As Monotherapy and in Combination with Azacitidine (AZA) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) and Higher-Risk Myelodysplastic Syndromes/Neoplasms (HR-MDS) Patients (pts) (ASH 2023)
The median number of prior lines of AML therapy was 2 [range 1-4]; 25 (93%) had received venetoclax (VEN) and 23 (85%) had received a hypomethylating agent (HMA). SL-172154 was well tolerated up to 3 mg/kg as monotherapy and in combination with AZA. Preliminary efficacy signals were detected in UnTx TP53m-MDS and R/R AML. A response to SL-172154 monotherapy, dose-dependent increases in serum cytokines and accumulation of mature myeloid cells in BM suggest a potential role for CD40 stimulation.
Clinical • PK/PD data • Combination therapy • IO biomarker
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TP53 (Tumor protein P53) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD36 (thrombospondin receptor) • IL10 (Interleukin 10) • ITGAM (Integrin, alpha M) • CD40LG (CD40 ligand) • SIRPA (Signal Regulatory Protein Alpha)
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TP53 mutation • CXCL8 elevation
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Venclexta (venetoclax) • azacitidine • SL-172154
5ms
A Phase 1 Study of NKX101, a Chimeric Antigen Receptor Natural Killer (CAR-NK) Cell Therapy, with Fludarabine and Cytarabine in Patients with Acute Myeloid Leukemia (ASH 2023)
Because Ara-C is known to upregulate NKG2D ligand expression, use of Flu/Ara-C as an alternative to standard Flu/cyclophosphamide (Flu/Cy) for lymphodepletion (LD) was tested for NKX101...Patients had received a median of two prior lines of therapy, with all patients having previous venetoclax exposure (Table 1)...Despite being an allogeneic, non-HLA-matched cell product, NKX101 persisted for up to three weeks in PK testing. Directly comparing the data from patients treated with Flu/Cy with NKX101 versus Flu/Ara-C with NKX101 suggests that Flu/Ara-C can replace the Flu/Cy regimen common to CAR T cell therapy as LD without compromising overall NKX101 exposure.
Clinical • P1 data
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TP53 (Tumor protein P53) • RUNX1 (RUNX Family Transcription Factor 1) • IFNG (Interferon, gamma) • IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) • IL10 (Interleukin 10) • IL15 (Interleukin 15) • NKG2D (killer cell lectin like receptor K1) • ULBP1 (UL16 Binding Protein 1)
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TP53 mutation • CXCL8 elevation • CXCL8 expression
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Venclexta (venetoclax) • cytarabine • cyclophosphamide • fludarabine IV • NKX101
5ms
CAR T-Related Toxicities Based on Dynamic Proteomic Profiles Identifies Risk Factors for Cytokine Release Syndrome (CRS) and Immune Effector Cell -Associated Neurotoxicity Syndrome (ICANS) (ASH 2023)
Ide-cel (39%), liso-cel (36%), and axi-cel (17%) were the most used CAR-T cell products. All patients received lymphodepleting chemotherapy with fludarabine/cyclophosphamide...CONCLUSIONS In our comprehensive plasma proteomic profiles analysis, we identified cutoffs for IL3, IL6, IL5 and IL10 that may be predictive for CRS and ICANS regardless of CAR-T cell product. Our results are clinically applicable and may be used to recognize patients at risk for CRS and/or ICANS who may be eligible for prophylactic therapies.
Clinical • IO biomarker
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL10 (Interleukin 10) • IL5 (Interleukin 5)
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CXCL8 elevation
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cyclophosphamide • Yescarta (axicabtagene ciloleucel) • Breyanzi (lisocabtagene maraleucel) • fludarabine IV • Abecma (idecabtagene vicleucel)
5ms
Genome-Wide DNA Methylation Analysis Reveals Epigenetic Influence on Intracellular and Cytokine Signaling Pathways in Waldenström Macroglobulinemia Compared to IgM-MGUS (ASH 2023)
This study demonstrates differential DNA methylation of key genomic regions in WM compared to IgM-MGUS. Promotor methylation-based analysis reveals hypomethylation of several important cellular pathways involved in cytokine signaling, cell structure/ECM, and intracellular signaling. These results underscore the influence of epigenetics in the IgM-gammopathy disease spectrum and suggest the potential role of aberrant DNA methylation underlying the malignant progression from IgM-MGUS to WM.
Epigenetic controller
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FGFR (Fibroblast Growth Factor Receptor) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • SDC1 (Syndecan 1) • TGFB1 (Transforming Growth Factor Beta 1) • IL23A (Interleukin 23 Subunit Alpha) • IL15 (Interleukin 15)
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CXCL8 elevation • SDC1 positive • CXCL8 expression
5ms
Heixiaoyao Powder interferes with microglia polarization in AD model mice by regulating NOX2/ROS/NF-κB signaling pathway (PubMed, Zhongguo Zhong Yao Za Zhi)
In conclusion, Heixiaoyao Powder can alleviate neuronal damage and improve the learning and memory abilities of APP/PS1 mice. The mechanism of action may be related to the inhibition of NOX2/ROS/NF-κB signaling pathway, regulating the polarization of MG, increasing the expression of M2 type, inhibiting the expression of M1 type, and reducing the release of inflammatory factor.
Preclinical • Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • MRC1 (Mannose Receptor C-Type 1) • NFKBIA (NFKB Inhibitor Alpha 2)
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CXCL8 elevation
5ms
The Significant Impacts of Interleukin-8 Genotypes on the Risk of Colorectal Cancer in Taiwan. (PubMed, Cancers (Basel))
Additionally, individuals with IL-8 rs4017 AA genotype displayed significantly elevated serum IL-8 compared to those with TT genotype at a 1.73-fold level (p < 0.0001), indicating a correlation between genotype and phenotype. In conclusion, the genotypes of IL-8 rs4017, along with their associated expression levels, can potentially serve as predictive markers for the risk of CRC.
Journal
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CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation • CXCL8 expression
5ms
Older adults' self-reported prospective memory lapses in everyday life: Connections to inflammation and gender. (PubMed, J Psychosom Res)
Elevated levels of IL-8 in older men may possibly be an early indicator of neurodegeneration that relates to PM performance. Future studies should continue to examine PM and inflammation across genders to identify possible mechanisms through which these constructs may indicate neurodegeneration and dementia risk.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL10 (Interleukin 10) • IL1B (Interleukin 1, beta) • IL4 (Interleukin 4) • CRP (C-reactive protein)
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CXCL8 elevation
5ms
Elevated baseline circulating IL-8 is associated with increased expression of the IMmotion myeloid gene signature (GS) in metastatic clear cell renal cell carcinoma (mRCC) patients (pts) treated with nivolumab (nivo) within the NIVOREN GETUG-AFU 26 study. (ESMO-IO 2023)
No significant correlations between baseline circulating IL-8 and the other two GS, VEGF or CD163 expression were observed. Conclusions In our study, elevated baseline circulating IL-8 was not only significantly associated with higher levels of other circulating inflammatory markers, but also with increased expression of the myeloid inflammation gene signature at tumor level in mRCC pts.
Clinical • Gene Signature • PD(L)-1 Biomarker • IO biomarker • Metastases
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CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD163 (CD163 Molecule)
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CXCL8 elevation • VEGFA expression • CD163 expression • CXCL8 expression
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Opdivo (nivolumab)
6ms
Molecular interaction analysis of anti-IL-8 scFv-10F8-6His against IL-8 monomer through molecular docking and molecular dynamic simulations. (PubMed, J Biomol Struct Dyn)
Furthermore, the result of decomposition residues analysis is in good agreement with the interaction analysis data. Current study provides a list of important interacting residues and further scrutiny on these residues is essential for future development and design of a new and stable recombinant antibody against IL-8.Communicated by Ramaswamy H. Sarma.
Journal
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CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation • CXCL8 expression
6ms
Urinary IL-6 and IL-8 as predictive markers in bladder urothelial carcinoma: A pilot study. (PubMed, Cancer Cytopathol)
The presence of IL-6 and IL-8 in urine specimens may have predictive value for urothelial carcinoma. However, a large longitudinal study is required to statistically eliminate confounding factors and support this theory.
Journal
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IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • CCL18 (C-C Motif Chemokine Ligand 18)
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CXCL8 elevation
6ms
Systemic Inflammatory Mediator Levels in Non-proliferative Diabetic Retinopathy Patients with Diabetic Macular Edema. (PubMed, Curr Eye Res)
The changed levels of serum inflammatory mediators suggest that the systemic inflammatory mediators are involved in the pathogenesis of NPDR patients with DME. Such effects can guide clinical monitoring, diagnostic and therapeutic approaches for DME patients at an early stage.
Journal
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IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL23A (Interleukin 23 Subunit Alpha) • IL33 (Interleukin 33)
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CXCL8 elevation
6ms
Tetraspanins from the liver fluke Opisthorchis viverrini stimulate cholangiocyte migration and inflammatory cytokine production. (PubMed, Folia Parasitol (Praha))
Finally, both rLEL-Ov-TSP-2 and rLEL-Ov-TSP-3 significantly enhanced migration of both M213 and H69 cell lines. These findings indicated that O. viverrini CD63 family tetraspanins can promote a cancerous microenvironment by enhancing innate immune responses and migration of biliary epithelial cells.
Journal
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IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
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IL6 elevation • CXCL8 elevation • CXCL8 expression • IL6 expression
6ms
Isorhamnetin Influences the Viability, Superoxide Production and Interleukin-8 Biosynthesis of Human Colorectal Adenocarcinoma HT-29 Cells In Vitro. (PubMed, Life (Basel))
The anti-inflammatory effect of isorhamnetin was evident due to decreased IL-8 production, and the most significant decline in IL-8 concentration was observed after 24 h treatment in cells with induced inflammation. We demonstrated that isorhamnetin can suppress the proliferation of HT-29 cells, and this effect was correlated with pro-oxidative and anti-inflammatory activity of isorhamnetin.
Preclinical • Journal
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CXCL8 (Chemokine (C-X-C motif) ligand 8)
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CXCL8 elevation
6ms
Extracellular vesicles promote activation of pro-inflammatory cancer-associated fibroblasts in oral cancer. (PubMed, Front Cell Dev Biol)
These CAFs seem to have unique properties, differing from TGFβ-activated CAFs. Gaining an understanding of the interplay between EVs and stromal cells such as CAFs could lead to further insights into OSCC tumorigenesis and potential novel therapeutics.
Journal
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CXCL8 (Chemokine (C-X-C motif) ligand 8) • CXCL5 (Chemokine (C-X-C motif) ligand 5)
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CXCL8 elevation
7ms
CT041 CAR T cell therapy for Claudin18.2-positive metastatic pancreatic cancer. (PubMed, J Hematol Oncol)
Patient experienced grade 2 CRS, which was controlled with tocilizumab...Elevating IL-8 and declining TGF-β1 were also observed. The tumor is still under well control until the last follow-up on July 18, 2023.
Journal • CAR T-Cell Therapy • Metastases
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CLDN18 (Claudin 18) • CD8 (cluster of differentiation 8) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD4 (CD4 Molecule) • TGFB1 (Transforming Growth Factor Beta 1)
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CXCL8 elevation
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satricabtagene autoleucel (CT041) • Actemra IV (tocilizumab)
7ms
The Relation of Lifestyle with Inflammation at the Time of Diagnosis in Patients with Colorectal Cancer. (PubMed, Cancers (Basel))
An overall unhealthier lifestyle indicated by a lower WCRF/AICR lifestyle score and a higher risk of malnutrition according to the MUST score at the time of diagnosis was associated with elevated levels of inflammatory markers. These findings can contribute to formulating lifestyle advice to improve treatment outcomes and prognosis in patients having CRC in the future.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL10 (Interleukin 10) • CRP (C-reactive protein)
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CXCL8 elevation • IL10 elevation
7ms
Transcriptomic profiling of peripheral blood cells in HPV-associated carcinoma patients receiving combined valproic acid and avelumab. (PubMed, Mol Oncol)
We found differential therapeutic effects for VA and avelumab in NRs vs Rs. Thus, our results imply that measuring the plasma IL-8/IL-18 and bulk RNA-seq of PBMCs may serve as valuable biomarkers to predict immunotherapy outcomes.
Journal • PD(L)-1 Biomarker • IO biomarker
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CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL18 (Interleukin 18)
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CXCL8 elevation
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Bavencio (avelumab)
7ms
Elevated expression levels of COX-2, IL-8 and VEGF in colon adenocarcinoma. (PubMed, Cell Mol Biol (Noisy-le-grand))
However, MMP-2 and MMP-9 expression levels did not change between tumor and normal tissues (p>0.05). Upregulated expression levels of COX-2, IL-8 and VEGF might occur in the early stages of tumorigenesis and detection of these mRNA levels may be beneficial for early diagnosis and management of colon tumors.
Journal
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CXCL8 (Chemokine (C-X-C motif) ligand 8) • MMP2 (Matrix metallopeptidase 2) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • MMP9 (Matrix metallopeptidase 9)
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CXCL8 elevation • CXCL8 expression