Finally, we delineate the distinct features of malignant epithelial cells in primary and recurrent tumors, providing a theoretical foundation for the precise selection of targeted therapy for tumors at different stages. In summary, the current study offers a comprehensive landscape and deep insight into epithelial and microenvironmental reprogramming throughout initiation, progression, lymph node metastasis and recurrence of head and neck squamous cell carcinoma.

9 months ago

Journal

CD8 (cluster of differentiation 8) • SPP1 (Secreted Phosphoprotein 1) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • POSTN (Periostin)

CXCL13 expression • CXCL13 overexpression

10ms

Serum CXCL13 level is related to treatment response and predicts disease prognosis in Waldenström macroglobulinemia. (PubMed, Ann Hematol)

Our study concludes that serum CXCL13 levels decrease in WM patients treated with various regimens and correlate with treatment response. Detecting serum CXCL13 at baseline or after treatment help in predicting prognosis.

10 months ago

Journal

B2M (Beta-2-microglobulin) • CXCL13 (Chemokine (C-X-C motif) ligand 13)

CXCL13 overexpression