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    DRUG:

    RGRN-305

    i
    Other names: RGRN-305, CUDC-305, Debio 0932, BEBT-305, MC2-32 HS, MC2-32
    Associations

    News

    Trials
    Company:
    BeBetter Med, Curis, Debiopharm, MC2 Therap, Regranion
    Drug class:
    HSP90 inhibitor
    Related drugs:
    Associations

    News

    Trials
    2ms
    A new TGF-β risk score predicts clinical and immune landscape in colorectal cancer patients. (PubMed, Ann Gastroenterol Surg)
    The feature gene TGFB2 could inhibit the efficacy of drugs such as XAV-939, Staurosporine, and Dasatinib, but promote the efficacy of drugs such as CUDC-305 and by-product of CUDC-305. Similarly, RBL1 could inhibit the drug action of Fluphenazine and Imiquimod but promote that of Irofulven. A CRC risk prognostic signature was developed on basis of TGF-β-related genes, which provides a reference for risk and further therapeutic selection of CRC patients.
    Journal • Tumor mutational burden • IO biomarker
    |
    TMB (Tumor Mutational Burden) • TGFB1 (Transforming Growth Factor Beta 1) • RBL1 (RB Transcriptional Corepressor Like 1) • TGFB2 (Transforming Growth Factor Beta 2)
    |
    dasatinib • Zyclara (imiquimod) • XAV-939 • fluphenazine • RGRN-305 • irofulven-1 (LP-100)
    8ms
    Combination of navitoclax (Bcl-2 and Bcl-xL inhibitor) and Debio-0932 (Hsp90 inhibitor) suppresses the viability of prostate cancer cells via induction of apoptotic signaling pathway. (PubMed, Med Oncol)
    The results revealed that Navitoclax-Debio-0932 combination potently induced intrinsic apoptotic pathway in PC3 cells rather than using drugs alone. The combined treatment of Navitoclax and Debio-0932 displayed synergistic cytotoxic and apoptotic effects on prostate cancer cells, presenting a promising approach for combination therapy in prostate cancer.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BCL2L1 (BCL2-like 1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • CASP7 (Caspase 7) • APAF1 (Apoptotic peptidase activating factor 1) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
    |
    navitoclax (ABT 263) • RGRN-305
    over3years
    Debio-0932, a second generation oral Hsp90 inhibitor, induces apoptosis in MCF-7 and MDA-MB-231 cell lines. (PubMed, Mol Biol Rep)
    Debio-0932 decreased the migration of HUVEC cells as compared to the control group. These results indicate that Debio-0932 is a promising compound to treat triple-negative breast cancer and hormone receptor-positive breast cancer, and their metastases.
    Preclinical • Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • CASP9 (Caspase 9)
    |
    HR positive • BCL2 expression • BAX expression
    |
    RGRN-305