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over4years
Tumors Resistant to Checkpoint Inhibitors Can Become Sensitive after Treatment with Vascular Disrupting Agents. (PubMed, Int J Mol Sci)
Histological assessment of CD4/CD8 expression actually showed decreased levels up to 10 days after treatment with OXi4503 (50 mg/kg). Thus, the non-immunogenic C3H mammary carcinoma was unresponsive to checkpoint inhibitors, but became responsive in mice treated with VDAs, although the mechanism remains unclear.
Journal • Checkpoint inhibition • PD(L)-1 Biomarker
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CD8 (cluster of differentiation 8)
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CD8 expression
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combretastatin A1 di-phosphate (OXi4503)