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    CANCER:

    CNS Tumor

    Related cancers:
    1d
    Detection of actionable mutations in the cerebrospinal fluid and concordance/discordance with extracranial mutations in patients with metastatic breast cancer and leptomeningeal disease. (PubMed, Ther Adv Med Oncol)
    We observed variable concordance and heterogeneity in the detection of actionable mutations between the CSF, blood, and tumor tissue, supporting the value of investigating the CSF to identify novel targets and resistance mechanisms. Larger studies are needed to assess the clinical utility of these observations, particularly with the development of novel targeted CNS-penetrant agents.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2)
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    HR positive • HER-2 negative
    1d
    First reported case in Brazil of intraventricular pilocytic astrocytoma in an adult patient with literature review. (PubMed, Discov Oncol)
    This case illustrates a rare intraventricular PA in an adult, confirmed through clinical, radiological, and histopathological integration. It emphasizes the importance of including PA in the differential diagnosis of intraventricular tumors in adults and may contribute to guiding recognition and management of rare ventricular tumors in this population.
    Journal
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    IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • MTAP (Methylthioadenosine Phosphorylase) • ATRX (ATRX Chromatin Remodeler) • GFAP (Glial Fibrillary Acidic Protein) • OLIG2 (Oligodendrocyte Transcription Factor 2)
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    IDH1 mutation • IDH1 R132
    2d
    PNOC029_Tovorafenib for the treatment of newly diagnosed or recurrent craniopharyngioma in children and young adults (2024-511510-20-00)
    P1/2, N=5, Not yet recruiting, Prinses Maxima Centrum voor Kinderoncologie B.V.
    New P1/2 trial
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    Ojemda (tovorafenib)
    2d
    Multinodular and vacuolating neuronal tumor: molecular genetics and DNA methylation analysis of 12 cases. (PubMed, J Pathol)
    Only one patient died 16 months after surgery due to an unrelated traffic accident.
    Journal
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    EGFR (Epidermal growth factor receptor) • BRAF (B-raf proto-oncogene) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • TERT (Telomerase Reverse Transcriptase) • SOX10 (SRY-Box 10) • GFAP (Glial Fibrillary Acidic Protein) • OLIG2 (Oligodendrocyte Transcription Factor 2)
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    BRAF V600E • BRAF V600 • IDH1 mutation • IDH2 mutation • FGFR2 mutation • FGFR2 fusion • IDH mutation + BRAF V600E
    2d
    Rare germline variants contribute to glioma predisposition: Whole-genome analysis of a regional cohort of glioma patients. (PubMed, Neurooncol Adv)
    These results suggest a contribution of rare germline variants to glioma risk, particularly in genes involved in DNA repair. While several genes are indicated as enriched with rare variants, only TP53 validates across all 3 patient sets.
    Journal
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    TP53 (Tumor protein P53) • DNMT3A (DNA methyltransferase 1) • CREBBP (CREB binding protein)
    2d
    IL-12-secreting CAR-T cells reprogram the tumor microenvironment and improve efficacy against heterogeneous models of glioblastoma. (PubMed, J Immunother Cancer)
    This study demonstrates the pleiotropic benefits of IL-12 armored CAR-T cells with improved targeting of antigen-positive tumor cells and simultaneous remodeling of the microenvironment to engage adaptive immunity against antigen-negative clones. This strategy offers a potential clinically actionable approach to improve outcomes in GBM by circumventing the need for toxic lymphodepletion and addressing tumor heterogeneity.
    Journal • IO biomarker
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    EGFR (Epidermal growth factor receptor) • CD8 (cluster of differentiation 8)
    2d
    Monitoring the Response of a Pineal Parenchymal Tumor of Intermediate Differentiation With Cerebrospinal Fluid Dissemination Using a Circulating Tumor Cell Assay. (PubMed, Cureus)
    Although leptomeningeal metastasis is not uncommon in patients with PPTID, the optimal monitoring approach remains unclear. While this assay remains investigational, it may represent a promising strategy to address an unmet need in the management of PPTID with LMD.
    Journal • Circulating tumor cells
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    CNSide™ Cerebrospinal Fluid Assay
    2d
    The Utility of Hypoxia Inducible Factor 1 Subunit Alpha (HIF1A) in the Differential Diagnosis of Pancreatic Cystic Neoplasms. (PubMed, Int J Surg Pathol)
    CA9 lacks diagnostic specificity. Incorporating HIF1A assessment into diagnostic algorithms could improve the preoperative classification and management of PCNs.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • CA9 (Carbonic anhydrase 9)
    2d
    A Rare Thoracolumbar Spinal Atypical Teratoid/Rhabdoid Tumor in a 7-Year-Old Child: Diagnostic Challenges and Therapeutic Considerations. (PubMed, Int J Surg Pathol)
    Despite maximal surgical and multimodal therapy, outcomes remain dismal, emphasizing the urgent need for collaborative research exploring targeted molecular and immunotherapeutic strategies. This case report expands limited literature, offering valuable insights for early recognition and management of spinal AT/RT in older pediatric patients.
    Journal • IO biomarker
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    SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1)
    2d
    Discovery of genetic susceptibility variants in pediatric and adult ependymoma. (PubMed, Neurooncol Adv)
    Several significant intronic variants were harbored in genes associated with cancer and neurological disease. Future studies are needed to investigate the role of these age-specific alterations in ependymoma pathogenesis.
    Journal
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    EDIL3 (EGF Like Repeats And Discoidin Domains 3)
    7d
    Integrative computational pipeline for the in silico prioritization of potential KIF11-targeting drug candidates in glioblastoma. (PubMed, J Mol Graph Model)
    Among four prioritized compounds, Ponatinib demonstrated the most favorable binding free energy, while Pimavanserin exhibited stable conformational behavior during simulation. These findings provide an in-silico prioritization framework for potential KIF11-targeting compounds in GBM. Experimental validation in relevant cellular and in vivo models will be required to determine biological and therapeutic relevance.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • KIF11 (Kinesin Family Member 11) • KIF20A (Kinesin Family Member 20A)
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    Iclusig (ponatinib)
    7d
    Molecular immune signature identifies microglia and NK cell infiltration as a favorable prognostic marker in adult-type high-grade glioma. (PubMed, ESMO Open)
    These integrated findings underscore the beneficial immune microenvironment in LTS HGG driven by specific innate and adaptive immune components. This immune signature may serve as a prognostic indicator and guide immunomodulatory therapeutic strategies for gliomas.
    Journal
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    CD123 (Interleukin 3 Receptor Subunit Alpha) • LAMP1 (Lysosomal Associated Membrane Protein 1) • HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • NOS2 (Nitric Oxide Synthase 2)