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    DRUG:

    CM-728

    i
    Other names: CM-728, CM728, CM 728
    Associations

    News

    Trials
    Company:
    Ceamed
    Drug class:
    Apoptosis stimulant, STAT3 inhibitor
    Related drugs:
    Associations

    News

    Trials
    over1year
    Chemical-proteomics Identify Peroxiredoxin-1 as an Actionable Target in Triple-negative Breast Cancer. (PubMed, Int J Biol Sci)
    Furthermore, CM728 exerted a strong synergistic antiproliferative effect with docetaxel in vitro and this combination was more effective than the individual treatments in vivo. Taken together, our results identify a novel compound with antitumoral properties against TNBC. In addition, we describe the mechanism of action of this drug and provide a rationale for the use of Prdx1 inhibitors, such as CM728, alone or in combination with other drugs, for the treatment of TNBC.
    Journal
    |
    PRDX1 (Peroxiredoxin 1)
    |
    docetaxel • CM-728