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CDKN1B expression
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Other names: P27KIP1, CDKN4, MEN1B, MEN4, CDKN1B, Cyclin Dependent Kinase Inhibitor 1B, Cyclin-Dependent Kinase Inhibitor P27
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Entrez ID:
20d
Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma. (PubMed, Cell Mol Life Sci)
Moreover, the overexpression of OC2 or SKP2 in the knockout HCC cell line clearly inhibited the acetylation level of p53 and reduced cell apoptosis. This study revealed that OC2 could regulate the apoptosis of HCC cells through the SKP2/p53/p21 axis, which may provide some therapeutic targets for HCC in the clinic.
Journal • Tumor cell
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ONECUT2 (One Cut Homeobox 2) • SKP2 (S-phase kinase-associated protein 2)
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CDKN1B expression
25d
Multilineage Pituitary Neuroendocrine Tumors Expressing TPIT and SF1: A Clinicopathological Series of Six Tumors. (PubMed, Endocr Pathol)
Irrespective of functional status of a PitNET, routine application of pituitary transcription factors is warranted to identify these tumors. Data on the molecular correlates and clinical significance are still needed for these rare multilineage PitNETs.
Journal
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GATA3 (GATA binding protein 3) • PRL (Prolactin)
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CDKN1B expression
1m
Encapsulation of soybean lunasin and amaranth unsaponifiable matter in liposomes induces cell cycle arrest in an allograft melanoma mouse model. (PubMed, Sci Rep)
Therefore, melanoma tumor development was prevented by the overexpression of cell cycle inhibitors p16, p21, p27, and p53 due to UM + LunLip treatments. Since the topical application was effective, less invasive, and more practical for the user, this application will be recommended for future steps in in vivo studies.
Preclinical • Journal
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CCND1 (Cyclin D1) • CDK6 (Cyclin-dependent kinase 6) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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CCND1 expression • TP53 overexpression • CDKN1B expression
1m
Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition. (PubMed, Cell Biochem Funct)
Furthermore, western blot analysis revealed that Biochanin A-treated cells exhibited lower expression of the Bcl-2, p-PI3K and p-AKT and higher expression of proapoptotic genes, including Bax, Caspase-3, Caspase-9, and cytochrome c. Additionally, PCR array analysis indicated that the gene expression levels of cyclin D3, cyclin B1, CDK1, CDK2, and CDK4 were downregulated, while the expression levels of p21, p27, and p53 were significantly upregulated. These results suggest that Biochanin A can suppress the viability of breast cancer cells and induce apoptosis via the mitochondrial pathway, along with inhibition of the Pi3K/Akt signaling pathway and modulation of cell cycle markers.
Journal • IO biomarker
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TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • CDK4 (Cyclin-dependent kinase 4) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CCND3 (Cyclin D3) • CDK2 (Cyclin-dependent kinase 2) • CASP9 (Caspase 9) • CDK1 (Cyclin-dependent kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CCNB1 (Cyclin B1)
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BCL2 expression • TP53 expression • BAX expression • CDK2 expression • CDKN1B expression
1m
The expression of keratin 17 and p27 predicts clinical outcomes in colorectal cancer. (PubMed, APMIS)
Therefore, K17highp27low expression is an independent poor prognostic factor in colorectal cancer. Thus, high K17 and low p27 expression correlate with aggressive clinicopathologic behavior and can be used as poor prognostic markers in colorectal cancer.
Clinical data • Journal
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KRT17 (Keratin 17)
|
CDKN1B expression
2ms
TSPO deficiency promotes the progression of malignant peripheral sheath tumors by regulating the G2/M phase of the cell cycle via CDK1. (PubMed, Sci Rep)
More importantly, CDK1 knockdown induced significant cell cycle arrest in the G2/M phase. In summary, TSPO deficiency regulates the cell cycle in MPNSTs by targeting CDK1, which may be an effective molecular target for prognosis evaluation and treatment.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • NF1 (Neurofibromin 1) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • CCNA2 (Cyclin A2) • CDK2 (Cyclin-dependent kinase 2) • CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1) • HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1)
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NF1 mutation • CDKN1B expression
2ms
Correlation of magnetic resonance imaging and computed tomography with biological factor expression and lymph node metastasis in aggressive prostate cancer. (PubMed, Urol Int)
MRI and CT manifestations of aggressive PCa had certain characteristics; MRI manifestations and qMRI possessed a correlation with biological factors and LNM; ADC could be employed to assess the aggressiveness of PCa.
Journal • MRI
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PCNA (Proliferating cell nuclear antigen)
|
CDKN1B expression • PCNA expression
2ms
Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients. (PubMed, Curr Med Sci)
HBO is beneficial for glioblastoma. Glioblastoma patients with these predictive indicators may prolong survival with HBO therapy. These potential therapeutic targets especially COL1A1, ADAMTS1 and PTBP3 deserve further validation.
Journal • PD(L)-1 Biomarker • IO biomarker
|
NF1 (Neurofibromin 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • PD-1 (Programmed cell death 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • MDM4 (The mouse double minute 4) • CDK6 (Cyclin-dependent kinase 6) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • CA9 (Carbonic anhydrase 9) • COL1A1 (Collagen Type I Alpha 1 Chain) • MMP9 (Matrix metallopeptidase 9) • PCNA (Proliferating cell nuclear antigen) • ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1) • CDC42 (Cell Division Cycle 42) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • CXCR5 (C-X-C Motif Chemokine Receptor 5) • DDIT3 (DNA-damage-inducible transcript 3) • IGFBP3 (Insulin-like growth factor binding protein 3) • IGFBP5 (Insulin Like Growth Factor Binding Protein 5) • BAK1 (BCL2 Antagonist/Killer 1) • CDC25A (Cell Division Cycle 25A) • COL12A1 (Collagen Type XII Alpha 1 Chain) • COL8A1 (Collagen Type VIII Alpha 1 Chain) • EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MCM2 (Minichromosome maintenance complex component 2) • RHOJ (Ras Homolog Family Member J) • NLRP2 (NLR Family Pyrin Domain Containing 2)
|
TP53 expression • CXCL12 expression • CDK6 expression • CDKN1B expression • PCNA expression
2ms
Heterogeneous Transcriptional Landscapes in Human Sporadic Parathyroid Gland Tumors. (PubMed, Int J Mol Sci)
In conclusion, PAds display heterogeneous transcriptomic profiles which may contribute to the modulation of clinical and biochemical features. The general downregulated gene expression, characterizing a subgroup of PAds, suggests the tumor cells behave as quiescent resting cells, while the severity of PHPT may be associated with the loss of p73 and the lncRNA-mediated deregulation of histones.
Journal
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CCND1 (Cyclin D1) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • TP73 (Tumor Protein P73) • CDC73 (Cell Division Cycle 73) • HOXA-AS2 (HOXA Cluster Antisense RNA 2)
|
CCND1 expression • CDKN1B expression
3ms
Immunohistochemical markers in predicting behavior of bladder urothelial carcinoma. (PubMed, Caspian J Intern Med)
The higher intensity leads to poor prognosis (recurrence or metastasis). More studies must be done in this aspect to resolve the controversies and clarify the role of immunohistochemical markers in predicting BC behaviors.
Journal
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HER-2 (Human epidermal growth factor receptor 2) • CDH1 (Cadherin 1) • MME (Membrane Metalloendopeptidase) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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HER-2 overexpression • HER-2 expression • CDH1 expression • CDKN1B expression
3ms
Rho GTPase activating protein 11A promotes tongue squamous cell carcinoma proliferation and is a transcriptional target of forkhead box M1. (PubMed, J Dent Sci)
This study revealed the oncogenic role of ARHGAP11A in TSCC, highlighting its impact on cell-cycle control and tumor proliferation. Furthermore, the regulatory relationship between FOXM1 and ARHGAP11A provides new insights into the transcriptional networks in TSCC.
Journal
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CCNE1 (Cyclin E1) • RHOA (Ras homolog family member A) • FOXM1 (Forkhead Box M1)
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CCNE1 expression • RHOA mutation • CDKN1B expression
3ms
p27 Cell Cycle Inhibitor and Survival in Luminal-Type Breast Cancer: Gene Ontology, Machine Learning, and Drug Screening Analysis. (PubMed, J Breast Cancer)
The integration of ML and bioinformatic analyses of p27 has the potential to enhance risk stratification and facilitate personalized treatment strategies for patients with breast cancer.
Journal • Machine learning
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ER (Estrogen receptor) • PGR (Progesterone receptor) • CD8 (cluster of differentiation 8) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CDKN1B (Cyclin dependent kinase inhibitor 1B)
|
CDKN1B expression
|
serdemetan (JNJ-26854165) • voxtalisib (SAR245409)
3ms
Discovery of flavonoid-containing compound Lupalbigenin as anti-NSCLC cancer agents via suppression of EGFR and ERK1/2 pathway. (PubMed, Bioorg Chem)
Furthermore, our results demonstrated that LB showed potential anti-Ex20ins cancer activity through suppression of the EGFR and ERK1/2 signaling pathway in Ba/F3 cells bearing two to three amino acid insertion mutations. These findings suggested that LB might be valuable for further investigation as a potential candidate in the treatment of associated diseases.
Journal • IO biomarker
|
TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6) • CCNA2 (Cyclin A2)
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EGFR mutation • EGFR exon 20 insertion • CCND1 expression • TP53 expression • CDK6 expression • CDKN1B expression
3ms
Discovery of Novel [1,2,4]Triazolo[1,5-a]pyrimidine Derivatives as Novel Potent S-Phase Kinase-Associated Protein 2 (SKP2) Inhibitors for the Treatment of Cancer. (PubMed, J Med Chem)
Furthermore, compound E35 showed an obvious inhibitory effect on MGC-803 xenograft mice without obvious toxicity. All of these results suggest that compound E35 might be a valuable lead compound for antitumor agents targeting Skp2.
Journal
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CUL1 (Cullin 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • SKP2 (S-phase kinase-associated protein 2)
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CDKN1B expression
3ms
The Effect of Statins on Markers of Breast Cancer Proliferation and Apoptosis in Women with In Situ or Early-Stage Invasive Breast Cancer. (PubMed, Int J Mol Sci)
This single-arm study enrolled 24 women with stage 0-II invasive breast cancer who were administered daily simvastatin (20 mg) for 2-4 weeks between diagnosis and surgical resection...These results align with previous window-of-opportunity studies suggesting a pro-apoptotic role of statins in breast cancer. The increased expression of markers of cell cycle arrest and apoptosis seen in this window-of-opportunity study supports further investigation into the anti-cancer properties of statins in larger-scale clinical trials.
Journal
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CCND1 (Cyclin D1) • CASP3 (Caspase 3)
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CCND1 expression • CDKN1B expression
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simvastatin
3ms
A New Strategy for Adult T-Cell Leukemia Treatment Targeting Glycogen Synthase Kinase-3β. (PubMed, Eur J Haematol)
GSK-3β functions as an oncogene in ATL and could be a potential therapeutic target.
Journal
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TP53 (Tumor protein P53) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MCL1 (Myeloid cell leukemia 1) • BCL2L1 (BCL2-like 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • BIRC5 (Baculoviral IAP repeat containing 5) • BAX (BCL2-associated X protein) • CCNA2 (Cyclin A2) • XIAP (X-Linked Inhibitor Of Apoptosis) • CDK1 (Cyclin-dependent kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • GSK3B (Glycogen Synthase Kinase 3 Beta) • NFKBIA (NFKB Inhibitor Alpha 2) • BAK1 (BCL2 Antagonist/Killer 1) • JUNB (JunB Proto-Oncogene AP-1 Transcription Factor Subunit)
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MYC expression • MCL1 expression • TP53 expression • BIRC5 expression • BAX expression • CDKN1B expression
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elraglusib (9-ING-41) • LY2090314
4ms
PTOV1 facilitates colorectal cancer cell proliferation through activating AKT1 signaling pathway. (PubMed, Heliyon)
The pharmacological inhibition of AKT1 phosphorylation using MK2206 effectively counteracted the proliferative effects induced by PTOV1 overexpression. The ability of PTOV1 to enhance CRC cell proliferation via modulation of the AKT1 signaling pathway establishes it as a potential therapeutic target and a promising biomarker for prognostic stratification in CRC.
Journal
|
AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
|
CDKN1B expression
|
MK-2206
7ms
Tris(1,3-dichloro-2-propyl) phosphate-induced cytotoxicity and its associated mechanisms in human A549 cells. (PubMed, Toxicol Ind Health)
In addition, cell apoptosis was induced via altering the expression levels of Bcl-2, BAX, and BAK. Our study implies that TDCIPP may pose potential health risks to the human respiratory system and its toxicity should not be neglected.
Journal • IO biomarker
|
BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • CDK4 (Cyclin-dependent kinase 4) • CDK6 (Cyclin-dependent kinase 6) • BAX (BCL2-associated X protein) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
|
BCL2 expression • CCND1 expression • BAX expression • CDK6 expression • CDKN1B expression
7ms
Regulatory effects of statins on Akt signaling for prevention of cancers. (PubMed, Cell Signal)
Hence, targeting Akt shows promise as an effective approach to cancer prevention and therapy. This review aims to provide a comprehensive discussion on the specific impact of statins through Akt signaling in different types of cancer.
Journal
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CDK2 (Cyclin-dependent kinase 2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
|
CDKN1B expression
8ms
Non-canonical deubiquitination of OTUB1 induces IFNγ-mediated cell cycle arrest via regulation of p27 stability. (PubMed, Oncogene)
Src downregulation reduced OTUB1 and p27 expression, suggesting that IFNγ-induced cell cycle arrest is mediated by the Src-OTUB1-p27 signaling pathway. Our findings highlight the pivotal role of OTUB1 in IFNγ-induced p27 expression and cell cycle arrest, offering therapeutic implications.
Journal
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IFNG (Interferon, gamma) • OTUB1 (OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1)
|
IFNG expression • CDKN1B expression
8ms
Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells. (PubMed, Oncol Rep)
Targeted gene KD of LANCL2 and PPARγ abrogated the cellular responses to ABA. Taken together, these data demonstrate that ABA may induce dormancy in PCa cell lines through LANCL2 and PPARγ signaling, and suggest novel targets to manage metastatic PCa growth.
Journal • Metastases
|
NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • LANCL2 (LanC Like 2)
|
CDKN1B expression
8ms
Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade. (PubMed, J Mol Histol)
Our study substantiates that GSG2 is able to phosphorylate GSK3α at Ser21 and then leads to the reduction of p27 expression, resulting in cell cycle acceleration and cell proliferation promotion. Thus, GSG2 may have the potential to become a promising target in EOC.
Journal
|
HASPIN (Histone H3 Associated Protein Kinase)
|
HASPIN expression • CDKN1B expression
8ms
Tolypothrix Dichloromethane Ethylacetate fraction (TDEF) inhibits cisplatin resistance H357 cell through PI3K/AKT/beta-catenin pathway. (PubMed, Am J Cancer Res)
The mechanistic pathway of apoptotic cell death in H357cisR was done through inhibiting β-catenin through GSK3β in turn activated by AKT. The phosphorylated β-catenin leads to proteasome degradation and unable to translocation to nucleus thereby activating c-Myc, survivin, Cyclin D and upregulate p21 expression which lead to cell cycle arrest in G0/G1 phase.
Journal • IO biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • BIRC5 (Baculoviral IAP repeat containing 5) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • CASP7 (Caspase 7) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
|
BIRC5 expression • CDKN1B expression
|
cisplatin
9ms
Network Pharmacology Prediction: Mechanism Study of Puerarin in the Treatment of Giant Cell Tumors of Bone (clinicaltrials.gov)
P=N/A, N=145, Completed, Changye Zou
New trial
|
ER (Estrogen receptor)
|
ER expression • CDKN1B expression
9ms
PCID2 is highly expressed in gastric cancer and affects the prognosis by regulating cancer cell cycle and proliferation (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)
PCID2 is highly expressed in gastric cancer tissues in close correlation with poor prognosis of the patients. High PCID2 expression promotes gastric cancer proliferation and cell cycle progression by inhibiting the expression of p27 and p16.
Journal
|
CCND1 (Cyclin D1) • CDK6 (Cyclin-dependent kinase 6) • CA 19-9 (Cancer antigen 19-9)
|
CCND1 expression • CDK6 expression • CDKN1B expression
9ms
Oleanolic acid promotes liver regeneration after partial hepatectomy via regulating pregnane X receptor signaling pathway in mice. (PubMed, Chem Biol Interact)
Silencing of Pxr further confirmed that OA-mediated upregulation of proliferation-related proteins depended on PXR. The current study illustrated that OA exhibited a significant promoting effect on liver regeneration following PHx, potentially through regulation of the PXR signaling pathway to accelerate liver recovery.
Preclinical • Journal
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CCND1 (Cyclin D1) • CCNE1 (Cyclin E1) • UGT1A1 (UDP glucuronosyltransferase family 1 member A1) • FOXO1 (Forkhead box O1) • PCNA (Proliferating cell nuclear antigen) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • RBL2 (RB Transcriptional Corepressor Like 2)
|
CCND1 expression • UGT1A1*1*1 • CCNE1 expression • CDKN1B expression • PCNA expression
9ms
TWIST1 is a critical downstream target of the HGF/MET pathway and is required for MET driven acquired resistance in oncogene driven lung cancer. (PubMed, Oncogene)
TWIST1 mediated MET TKI resistance through suppression of p27 expression and genetic or pharmacologic inhibition of TWIST1 overcame TKI resistance in vitro and in vivo. Our findings suggest that targeting TWIST1 may be an effective therapeutic strategy to overcome resistance in MET-driven NSCLC as well as in other oncogene driven subtypes in which MET amplification is the resistance mechanism.
Preclinical • Journal
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MET (MET proto-oncogene, receptor tyrosine kinase) • TWIST1 (Twist Family BHLH Transcription Factor 1)
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MET amplification • MET overexpression • MET mutation • CDKN1B expression
10ms
Network pharmacology analysis and experimental verification of the antitumor effect and molecular mechanism of isocryptomerin on HepG2 cells. (PubMed, Drug Dev Res)
Additionally, ISO promoted ROS accumulation in HepG2 cells, and ISO-induced apoptosis, arrest cell cycle, and inhibition of migration were reversed by an ROS scavenger, N-acetyl- l-cysteine. Overall, ISO induced cell apoptosis and cell cycle arrest and inhibited cell migration by ROS-mediated EGFR, AKT, and MAPK signaling pathways in HepG2 cells.
Journal • PARP Biomarker
|
CDK4 (Cyclin-dependent kinase 4) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CDH1 (Cadherin 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CASP3 (Caspase 3) • CDH2 (Cadherin 2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • MAPK8 (Mitogen-activated protein kinase 8)
|
CDH1 expression • CDKN1B expression
10ms
Regulation and tumor-suppressive function of the miR-379/miR-656 (C14MC) cluster in cervical cancer. (PubMed, Mol Oncol)
Thus, C14MC is a tumor-suppressive and methylation-regulated miRNA cluster in CC. Reactivation of C14MC can be useful in the management of CC.
Journal
|
CCNE1 (Cyclin E1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • MIR494 (MicroRNA 494)
|
MYC overexpression • CCNE1 overexpression • CDKN1B expression
11ms
RACK1 promotes the occurrence and progression of cervical carcinoma. (PubMed, J Clin Lab Anal)
Taken together, we concluded that RACK1 stimulates tumorigenesis and progression of cervical cancer via modulating the proliferation of tumor cells, implying that targeting RACK1 may serve as a promising method for cervical cancer therapy.
Journal
|
CCND1 (Cyclin D1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • RACK1 (Receptor For Activated C Kinase 1)
|
CCND1 expression • CDKN1B expression
11ms
Up and away with cervical cancer: IL-29 is a promising cytokine for immunotherapy of cervical cancer due to its powerful upregulation of p18, p27, and TRAILR1. (PubMed, Med Oncol)
IL-29 inhibits cervical cancer cell growth by inhibiting cell proliferation and promoting cell apoptosis. Thus, IL-29 might be a promising cytokine for immunotherapy of cervical cancer.
Journal • IO biomarker
|
CASP3 (Caspase 3) • TNFRSF10A (TNF Receptor Superfamily Member 10a) • IFNL1 (Interferon Lambda 1)
|
CDKN1B expression
11ms
Low CDKN1B Expression Associated with Reduced CD8+ T Lymphocytes Predicts Poor Outcome in Breast Cancer in a Machine Learning Analysis. (PubMed, J Pers Med)
In in vitro drug screening, BMS-345541 demonstrated efficacy as a therapeutic targeting of CDKN1B, effectively impeding the growth of breast cancer cells characterized by low CDKN1B expression. The inclusion of CDKN1B expression in GBM models increased the accuracy of survival predictions. CDKN1B expression plays a significant role in breast cancer progression, implying that targeting CDKN1B might be a promising strategy for treating breast cancer.
Journal • IO biomarker • Machine learning
|
CD8 (cluster of differentiation 8) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CDKN1B (Cyclin dependent kinase inhibitor 1B)
|
CDKN1B expression
|
BMS-345541
11ms
Syndromic MEN1 parathyroid adenomas consist of both subclonal nodules and clonally independent tumors. (PubMed, Virchows Arch)
NGS demonstrated both subclonal evolution and the existence of clonally unrelated tumors.Syndromic MEN1 parathyroid adenomas therefore consist of multiple clones with subclones, which supports the current concept of the novel WHO classification of parathyroid tumors (2022). p27 expression was lost in a large fraction of MEN1 parathyroids and must therefore be used with caution in suggesting MEN4.
Journal
|
CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • MEN1 (Menin 1)
|
CDKN1B expression
11ms
AIbZIP/CREB3L4 Promotes Cell Proliferation via the SKP2-p27 Axis in Luminal Androgen Receptor Subtype Triple Negative Breast Cancer. (PubMed, Mol Cancer Res)
Our findings demonstrate that AIbZIP is a novel p27-SKP2 pathway-regulating factor and a potential molecule that contributes to LAR subtype TNBC progression. Implications: This research shows new mechanism for the proliferation of LAR subtype TNBC regulated by AIbZIP, that may provide novel insight into the LAR subtype TNBC progression and the molecular mechanisms involved in cell proliferation.
Journal
|
AR (Androgen receptor) • SKP2 (S-phase kinase-associated protein 2)
|
CDKN1B expression
11ms
MLLT11 Regulates Endometrial Stroma Cell Adhesion, Proliferation and Survival in Ectopic Lesions of Women with Advanced Endometriosis. (PubMed, Int J Mol Sci)
We found that the cellular phenotype of MLLT11 knockdown cells resembled the phenotype of the primary endometriosis stroma cells of the lesion, where the levels of MLLT11 are significantly reduced compared to the eutopic stroma cells of women without the disease. Overall, our results indicate that MLLT11 may be a new clinically relevant player in the pathogenesis of endometriosis.
Journal • IO biomarker • Stroma • Metastases
|
BCL2 (B-cell CLL/lymphoma 2) • ACTA2 (Actin Alpha 2 Smooth Muscle) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • TGFB2 (Transforming Growth Factor Beta 2)
|
CDKN1B expression
12ms
Licochalcone C Inhibits the Growth of Human Colorectal Cancer HCT116 Cells Resistant to Oxaliplatin. (PubMed, Biomol Ther (Seoul))
Overall, LCC showed anticancer activity against both Ox-sensitive and Ox-resistant CRC cells by targeting EGFR and AKT, inducing ROS generation and disrupting MMP. Thus, LCC may be potential therapeutic agents for the treatment of Ox-resistant CRC cells.
Journal
|
EGFR (Epidermal growth factor receptor) • CDK1 (Cyclin-dependent kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CCNB1 (Cyclin B1)
|
CDKN1B expression
|
oxaliplatin
1year
Genistein Induces Antiproliferative Activity and Apoptosis in Human Osteosarcoma Saos-2 Cells. (PubMed, Anticancer Res)
Genistein may inhibit proliferation through the up-regulation of p21 and p27 and viability by inducing apoptosis in Saos-2 cells.
Journal
|
TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • CASP7 (Caspase 7) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
|
CDKN1B expression
1year
SUZ12 inhibition attenuates cell proliferation of glioblastoma via post-translational regulation of CDKN1B. (PubMed, Genes Genomics)
Our findings suggest a novel role for SUZ12 in cell proliferation through post-translational regulation of CDKN1B in glioblastoma.
Journal
|
EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • SKP2 (S-phase kinase-associated protein 2) • SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit)
|
MYC expression • CDKN1B expression
1year
Lansoprazole inhibits the development of sessile serrated lesions by inducing G1 arrest via Skp2/p27 signaling pathway. (PubMed, J Gastroenterol)
Our data strongly suggest that lansoprazole is the most effective chemopreventive agent against SSL, and that lansoprazole induces G1 cell cycle arrest by downregulating Skp2 and upregulating p27 in SSL cells.
Journal
|
SKP2 (S-phase kinase-associated protein 2)
|
CDKN1B expression
1year
Azafuramidines as Potential Anticancer Agents: Pro-apoptotic Profile and Cell Cycle Arrest. (PubMed, Bioorg Med Chem Lett)
These derivatives had the potential to act as anticancer agents. and merit further investigations.
Journal
|
TP53 (Tumor protein P53) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
|
CDKN1B expression
1year
DAB2IP stabilizes p27 via suppressing PI3K/AKT signaling in clear cell renal cell carcinoma. (PubMed, Funct Integr Genomics)
Further studies confirmed that the proline-rich domain in C terminal (CPR) of DAB2IP suppressed AKT phosphorylation and p27 phosphorylation on S10. Hence, DAB2IP is essential for p27 protein stabilization in ccRCC, which is at less partly mediated by PI3K/AKT signaling pathway.
Journal
|
DAB2IP (DAB2 Interacting Protein)
|
CDKN1B expression
1year
Mechanism of Proliferation and Apoptosis of Acute Promyelocytic Leukemia Cell Line NB4 Induced by TPA (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)
TPA induces NB4 cell cycle arrest in G phase and promotes its apoptosis by regulating PIK3/AKT signaling pathway.
Preclinical • Journal • IO biomarker
|
MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CASP9 (Caspase 9) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • CCNA1 (Cyclin A1)
|
MYC expression • CCND1 expression • BAX expression • CDKN1B expression
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