News - CDKN1B expression

11ms

Anticancer and therapeutic efficacy of XPO1 inhibition in pancreatic ductal adenocarcinoma through DNA damage and modulation of miR-193b/KRAS/LAMC2/ERK/AKT signaling cascade. (PubMed, Life Sci)

Interestingly, the combination of eltanexor with gemcitabine showed significant anticancer activity in PDAC cells. Altogether, our findings revealed the crucial role of XPO1 in modulating the expression of oncogenic proteins, ncRNAs, and DNA damage during PDAC progression as well as identified novel therapeutic miR-193b/KRAS/LAMC2/ERK/AKT axis.

11 months ago

Journal • PARP Biomarker • IO biomarker

KRAS (KRAS proto-oncogene GTPase) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • CDH1 (Cadherin 1) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • XPO1 (Exportin 1) • VIM (Vimentin) • CASP9 (Caspase 9) • CDH2 (Cadherin 2) • LAMC2 (Laminin subunit gamma 2) • MIR193B (MicroRNA 193b) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CCNB1 (Cyclin B1) • SOX21-AS1 (SOX21 Antisense Divergent Transcript 1)

CCND1 expression • CDKN1B expression

gemcitabine • eltanexor (KPT-8602)

11ms

Red ginseng prevents niraparib-induced myelosuppression in C57BL/6 mice via inhibiting p53-mediated upregulation of p21 and p27. (PubMed, J Nat Med)

These findings indicate that RG might have therapeutic potential on niraparib-induced myelosuppression, which encourages further clinical trials. This study is the first to explore the efficacy and mechanism of RG in preventing myelosuppression induced by niraparib.

11 months ago

Preclinical • Journal • PARP Biomarker

TP53 (Tumor protein P53) • CCNE1 (Cyclin E1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)

TP53 expression • CCNE1 expression • CDKN1B expression

Zejula (niraparib)

1year

Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma. (PubMed, Cell Mol Life Sci)

Moreover, the overexpression of OC2 or SKP2 in the knockout HCC cell line clearly inhibited the acetylation level of p53 and reduced cell apoptosis. This study revealed that OC2 could regulate the apoptosis of HCC cells through the SKP2/p53/p21 axis, which may provide some therapeutic targets for HCC in the clinic.

1 year ago

Journal • Tumor cell

ONECUT2 (One Cut Homeobox 2) • SKP2 (S-phase kinase-associated protein 2)

CDKN1B expression

1year

Multilineage Pituitary Neuroendocrine Tumors Expressing TPIT and SF1: A Clinicopathological Series of Six Tumors. (PubMed, Endocr Pathol)

Irrespective of functional status of a PitNET, routine application of pituitary transcription factors is warranted to identify these tumors. Data on the molecular correlates and clinical significance are still needed for these rare multilineage PitNETs.

1 year ago

Journal

GATA3 (GATA binding protein 3) • PRL (Prolactin)

CDKN1B expression

1year

Encapsulation of soybean lunasin and amaranth unsaponifiable matter in liposomes induces cell cycle arrest in an allograft melanoma mouse model. (PubMed, Sci Rep)

Therefore, melanoma tumor development was prevented by the overexpression of cell cycle inhibitors p16, p21, p27, and p53 due to UM + LunLip treatments. Since the topical application was effective, less invasive, and more practical for the user, this application will be recommended for future steps in in vivo studies.

1 year ago

Preclinical • Journal

CCND1 (Cyclin D1) • CDK6 (Cyclin-dependent kinase 6) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)

CCND1 expression • TP53 overexpression • CDKN1B expression

1year

Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition. (PubMed, Cell Biochem Funct)

Furthermore, western blot analysis revealed that Biochanin A-treated cells exhibited lower expression of the Bcl-2, p-PI3K and p-AKT and higher expression of proapoptotic genes, including Bax, Caspase-3, Caspase-9, and cytochrome c. Additionally, PCR array analysis indicated that the gene expression levels of cyclin D3, cyclin B1, CDK1, CDK2, and CDK4 were downregulated, while the expression levels of p21, p27, and p53 were significantly upregulated. These results suggest that Biochanin A can suppress the viability of breast cancer cells and induce apoptosis via the mitochondrial pathway, along with inhibition of the Pi3K/Akt signaling pathway and modulation of cell cycle markers.

1 year ago

Journal • IO biomarker

TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • CDK4 (Cyclin-dependent kinase 4) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • CCND3 (Cyclin D3) • CDK2 (Cyclin-dependent kinase 2) • CASP9 (Caspase 9) • CDK1 (Cyclin-dependent kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CCNB1 (Cyclin B1)

BCL2 expression • TP53 expression • BAX expression • CDK2 expression • CDKN1B expression

1year

The expression of keratin 17 and p27 predicts clinical outcomes in colorectal cancer. (PubMed, APMIS)

Therefore, K17highp27low expression is an independent poor prognostic factor in colorectal cancer. Thus, high K17 and low p27 expression correlate with aggressive clinicopathologic behavior and can be used as poor prognostic markers in colorectal cancer.

1 year ago

Clinical data • Journal

KRT17 (Keratin 17)

CDKN1B expression

1year

TSPO deficiency promotes the progression of malignant peripheral sheath tumors by regulating the G2/M phase of the cell cycle via CDK1. (PubMed, Sci Rep)

More importantly, CDK1 knockdown induced significant cell cycle arrest in the G2/M phase. In summary, TSPO deficiency regulates the cell cycle in MPNSTs by targeting CDK1, which may be an effective molecular target for prognosis evaluation and treatment.

1 year ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • NF1 (Neurofibromin 1) • CASP3 (Caspase 3) • CASP8 (Caspase 8) • CCNA2 (Cyclin A2) • CDK2 (Cyclin-dependent kinase 2) • CDK1 (Cyclin-dependent kinase 1) • CCNB1 (Cyclin B1) • HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1)

NF1 mutation • CDKN1B expression

1year

Correlation of magnetic resonance imaging and computed tomography with biological factor expression and lymph node metastasis in aggressive prostate cancer. (PubMed, Urol Int)

MRI and CT manifestations of aggressive PCa had certain characteristics; MRI manifestations and qMRI possessed a correlation with biological factors and LNM; ADC could be employed to assess the aggressiveness of PCa.

1 year ago

Journal • MRI

PCNA (Proliferating cell nuclear antigen)

CDKN1B expression • PCNA expression

1year

Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients. (PubMed, Curr Med Sci)

HBO is beneficial for glioblastoma. Glioblastoma patients with these predictive indicators may prolong survival with HBO therapy. These potential therapeutic targets especially COL1A1, ADAMTS1 and PTBP3 deserve further validation.

1 year ago

Journal • PD(L)-1 Biomarker • IO biomarker

NF1 (Neurofibromin 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • PD-1 (Programmed cell death 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • MDM4 (The mouse double minute 4) • CDK6 (Cyclin-dependent kinase 6) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • CA9 (Carbonic anhydrase 9) • COL1A1 (Collagen Type I Alpha 1 Chain) • MMP9 (Matrix metallopeptidase 9) • PCNA (Proliferating cell nuclear antigen) • ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1) • CDC42 (Cell Division Cycle 42) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • CXCR5 (C-X-C Motif Chemokine Receptor 5) • DDIT3 (DNA-damage-inducible transcript 3) • IGFBP3 (Insulin-like growth factor binding protein 3) • IGFBP5 (Insulin Like Growth Factor Binding Protein 5) • BAK1 (BCL2 Antagonist/Killer 1) • CDC25A (Cell Division Cycle 25A) • COL12A1 (Collagen Type XII Alpha 1 Chain) • COL8A1 (Collagen Type VIII Alpha 1 Chain) • EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MCM2 (Minichromosome maintenance complex component 2) • RHOJ (Ras Homolog Family Member J) • NLRP2 (NLR Family Pyrin Domain Containing 2)

TP53 expression • CXCL12 expression • CDK6 expression • CDKN1B expression • PCNA expression

1year

Heterogeneous Transcriptional Landscapes in Human Sporadic Parathyroid Gland Tumors. (PubMed, Int J Mol Sci)

In conclusion, PAds display heterogeneous transcriptomic profiles which may contribute to the modulation of clinical and biochemical features. The general downregulated gene expression, characterizing a subgroup of PAds, suggests the tumor cells behave as quiescent resting cells, while the severity of PHPT may be associated with the loss of p73 and the lncRNA-mediated deregulation of histones.

1 year ago

Journal

CCND1 (Cyclin D1) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • TP73 (Tumor Protein P73) • CDC73 (Cell Division Cycle 73) • HOXA-AS2 (HOXA Cluster Antisense RNA 2)

CCND1 expression • CDKN1B expression

1year

Immunohistochemical markers in predicting behavior of bladder urothelial carcinoma. (PubMed, Caspian J Intern Med)

The higher intensity leads to poor prognosis (recurrence or metastasis). More studies must be done in this aspect to resolve the controversies and clarify the role of immunohistochemical markers in predicting BC behaviors.

1 year ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • CDH1 (Cadherin 1) • MME (Membrane Metalloendopeptidase) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)

HER-2 overexpression • HER-2 expression • CDH1 expression • CDKN1B expression