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DRUG CLASS:

CD228-targeted antibody-drug conjugate

3ms
Safety and Efficacy of BA1302 in Patients With Advanced Solid Tumors (clinicaltrials.gov)
P1, N=167, Not yet recruiting, Shandong Boan Biotechnology Co., Ltd
New P1 trial • Metastases
over1year
SGN-CD228A is an investigational CD228-directed antibody-drug conjugate with potent antitumor activity across a wide spectrum of preclinical solid tumor models. (PubMed, Mol Cancer Ther)
Overall, SGN-CD228A is a CD228-directed, investigational ADC that employs innovative technology and has compelling preclinical antitumor activity. SGN-CD228A is being investigated in an ongoing Phase I clinical trial (NCT04042480) in patients with advanced solid tumors.
Preclinical • Journal
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MELTF (Melanotransferrin)
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MELTF expression • MFI2 expression
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SGN-CD228A
almost2years
A Study of SGN-CD228A in Advanced Solid Tumors (clinicaltrials.gov)
P1, N=88, Terminated, Seagen Inc. | Trial completion date: Sep 2024 --> Mar 2023 | Active, not recruiting --> Terminated | Trial primary completion date: Sep 2024 --> Mar 2023; Study closed due to portfolio prioritization
Trial completion date • Trial termination • Trial primary completion date • Metastases
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EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1)
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HR positive • HER-2 negative • EGFR wild-type
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SGN-CD228A
almost2years
A Study of SGN-CD228A in Advanced Solid Tumors (clinicaltrials.gov)
P1, N=88, Active, not recruiting, Seagen Inc. | Recruiting --> Active, not recruiting | N=210 --> 88
Enrollment closed • Enrollment change • Metastases
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EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1)
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HR positive • HER-2 negative • EGFR wild-type
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SGN-CD228A
almost3years
A Study of SGN-CD228A in Advanced Solid Tumors (clinicaltrials.gov)
P1, N=210, Recruiting, Seagen Inc. | Trial completion date: Jan 2023 --> Sep 2024 | Trial primary completion date: Jan 2023 --> Sep 2024
Trial completion date • Trial primary completion date
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EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1)
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HR positive • HER-2 negative • EGFR wild-type
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SGN-CD228A
over4years
[VIRTUAL] SGN228-001: A phase I open-label dose-escalation, and expansion study of SGN-CD228A in select advanced solid tumors. (ASCO 2020)
Enrollment is ongoing in the US and planned in Europe. Research Funding: Seattle Genetics Inc.
Clinical • P1 data
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MELTF (Melanotransferrin)
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SGN-CD228A