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    GENE:

    CAV1 (Caveolin 1)

    i
    Other names: CAV1, CAV, Caveolin 1, caveolae protein, 22kDa
    6d
    4-MEC potentially triggers CAV1 via the BDNF-TrkB signaling pathway. (PubMed, Mol Cell Neurosci)
    These findings identify CAV1 as a potential critical mediator of 4-MEC's neuroadaptive effects through the BDNF-TrkB signal pathway to regulate neuroplasticity. It suggests a possible novel molecular target for synthetic cathinone toxicity, with potential implications for forensic research.
    Journal
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    CAV1 (Caveolin 1)
    8d
    Spectronaut and DIA-NN: A Comparison of their Performance in the Analysis of Lung Adenocarcinoma Biopsies. (PubMed, ACS Omega)
    Two of these DEPsHSPA5 and CAV1were also among the top 50 proteins showing the highest degrees of protein-protein interaction. The DEPs enabled classification of the LUAD patients into three subtypes; the clinical validity of the current subtypes will need to be substantiated in the future with additional LUAD samples and experimentation.
    Journal
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    CAV1 (Caveolin 1) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5)
    10d
    Quantitative assessment of arterial remodeling from confocal microscopy image analysis of the mid-gestation mouse decidua. (PubMed, Methods Cell Biol)
    Reflecting the loss of VSMCs during normal remodeling, SMA within the vascular media is markedly reduced between gd 7.5 and 9.5, while retention of SMA is a characteristic feature of impaired remodeling. Through quantitative analysis of the relative percentage of SMA within vessel walls, the methodology described here provides an objective means to assess impairment of the spiral artery remodeling process.
    Preclinical • Journal
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    IFNG (Interferon, gamma) • CAV1 (Caveolin 1)
    11d
    Dimensional Priming Reprograms Adipose-Derived Stromal Cells to Promote Pancreatic Cancer Progression. (PubMed, Cancers (Basel))
    Dimensional priming fundamentally reprograms ADSC phenotype and alters their stromal-immune interactions, generating a tumor-permissive state that accelerates PDAC progression. These findings identify mechanical cues as critical regulators of stromal plasticity and highlight dimensional priming as a potentially targetable axis within the PDAC microenvironment.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CAV1 (Caveolin 1) • IL10 (Interleukin 10) • MMP2 (Matrix metallopeptidase 2)
    14d
    Gene Expression Profiling to Unveil Novel Biomarkers for Early Diagnosis and Therapies for Breast Cancer. (PubMed, Curr Top Med Chem)
    The stability of the top three receptor-ligand complexes was validated through molecular dynamics simulations. Therefore, our findings could be a valuable resource for researchers and medical professionals, aiding in BC diagnosis and treatment.
    Journal • BRCA Biomarker • PARP Biomarker
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    EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • BRCA1 (Breast cancer 1, early onset) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CAV1 (Caveolin 1) • MIR155 (MicroRNA 155) • CD34 (CD34 molecule) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CD36 (thrombospondin receptor) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • CD31 (Platelet and endothelial cell adhesion molecule 1) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA)
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    Lynparza (olaparib) • lapatinib • Verzenio (abemaciclib) • Tukysa (tucatinib)
    15d
    Solvent-based or nab-paclitaxel plus ramucirumab for pretreated gastric cancer with peritoneal dissemination and prespecified biomarker analysis (P-SELECT/WJOG10617G): a randomised phase 2 trial in Japan. (PubMed, EClinicalMedicine)
    Taiho Pharmaceutical Co. Ltd.
    P2 data • Journal
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    CAV1 (Caveolin 1)
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    albumin-bound paclitaxel • Cyramza (ramucirumab)
    15d
    Caveolin-1 is upregulated in gastric cancer and is associated with tumor progression and prognosis in patients. (PubMed, Int J Clin Exp Pathol)
    High expression of CAV-1 in gastric cancer tissue is associated with poor prognosis and may be a potential biological marker for anti-gastric cancer treatment.
    Journal
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    CAV1 (Caveolin 1) • CA 19-9 (Cancer antigen 19-9)
    17d
    Citrate silver nanoparticles modulate estrogen signaling in estradiol-supplemented ER-positive breast cancer cells. (PubMed, Mol Cell Endocrinol)
    Our results suggest that the surface chemistry of silver nanoparticles may facilitate their ability to modulate estrogen signaling and interact with the estrogen receptor. Furthermore, the nanoplastics pollution may influence the cytotoxicity of silver nanoparticles. This paper highlights the importance of endocrine research in breast cancer, particularly within the context of nanoplastics pollution and the use of nanotechnology in breast cancer treatment.
    Journal
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    ER (Estrogen receptor) • CAV1 (Caveolin 1) • GPER1 (G Protein-Coupled Estrogen Receptor 1)
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    ER positive • ER negative
    20d
    Genomics Insights Into High-Latitude Adaptation of Tibetan Macaques. (PubMed, Adv Sci (Weinh))
    The shortened tail and increased fat accumulation represent key adaptations for thermoregulation and energy conservation in high-latitude habitats. Notably, all Tibetan macaque populations experienced long-term selection pressures from cold at high latitudes, which have not only shaped distinctive adaptive traits, but may also render the species particularly vulnerable to contemporary climate warming, particularly for the eastern populations.
    Journal
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    CAV1 (Caveolin 1) • ACACA (Acetyl-CoA Carboxylase Alpha) • PRKD1 (Protein Kinase D1)
    27d
    Cholesterol in glioblastoma: impaired Hh signaling enhances epigenetic modifiers and decreases CAV1. (PubMed, Cell Struct Funct)
    CAV1 gene silencing by siRNA validated its role in maintenance of stem-like phenotype and metabolic alterations of GBM spheroids. Collectively, this study demonstrated the regulatory role of Caveolin1 and cholesterol in maintaining stem-like characteristics of GBM spheroids and the importance of tumor models in better understanding of the molecular mechanism of GBM.Key words: Glioblastoma, cholesterol biosynthesis, stemness, Caveolin1, DNMT1, KDM5A, Gli1.
    Journal
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    CAV1 (Caveolin 1) • GLI1 (GLI Family Zinc Finger 1) • DNMT1 (DNA methyltransferase 1) • KDM5A (Lysine Demethylase 5A)
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    lovastatin
    27d
    Microenvironment Modulates Tumorigenicity of Breast Cancer Cells Depending on Hormone Receptor Status. (PubMed, Int J Mol Sci)
    In TNBC cells, both normal- and adjacent-CM partially shifted MDA-MB-231 morphology toward a more epithelial-like state, decreasing caveolin-1 levels, while adjacent-CM increased MMP9 expression. Overall, these results reveal that adipose tissue-derived soluble factors exert significant and subtype-dependent effects on BC tumorigenicity.
    Journal
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    CAV1 (Caveolin 1) • CD44 (CD44 Molecule) • KLF4 (Kruppel-like factor 4) • VIM (Vimentin) • MMP9 (Matrix metallopeptidase 9) • NANOG (Nanog Homeobox) • FABP4 (Fatty Acid Binding Protein 4)
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    HR positive