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    DRUG CLASS:

    β-catenin inhibitor

    Related drugs:
    8d
    Eribulin Mesylate-based Therapy in Patients With Advanced HER2-negative Breast Cancer Previously Treated With ADC (clinicaltrials.gov)
    P=N/A, N=400, Not yet recruiting, Fudan University
    New trial • Real-world evidence
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    HER-2 (Human epidermal growth factor receptor 2)
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    HER-2 negative
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    Halaven (eribulin mesylate)
    9d
    SWOG S1937: Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer (clinicaltrials.gov)
    P3, N=184, Active, not recruiting, National Cancer Institute (NCI) | Recruiting --> Active, not recruiting
    Enrollment closed
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    gemcitabine • paclitaxel • docetaxel • Halaven (eribulin mesylate) • Trodelvy (sacituzumab govitecan-hziy)
    14d
    Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma (clinicaltrials.gov)
    P1/2, N=126, Recruiting, HonorHealth Research Institute
    New P1/2 trial
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    BRAF (B-raf proto-oncogene)
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    MSI-H/dMMR • BRAF mutation • RAS wild-type
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    tegavivint (BC2059)
    15d
    Targeting phosphodiesterase 10A disrupts MAPK signaling pathways in the tumor microenvironment to unleash antitumor immunity. (PubMed, bioRxiv)
    Mechanistically, ADT-030 disrupts multiple components of the mitogen-activated protein kinase (MAPK) signaling network in both tumor cells and MDSCs, leading to induction of apoptosis in these populations. These findings highlight the multi-faceted impact of PDE10A inhibition as a therapeutic strategy that not only disrupts tumor-intrinsic oncogenic signaling to inhibit tumor progression but also reshapes the tumor immune microenvironment to unleash antitumor immunity.
    Journal
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    CD8 (cluster of differentiation 8) • BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3)
    15d
    SABINA: PIK3CA/PTEN-altered Advanced Breast Cancer Treated With MEN1611 Monotherapy or in Combination With Eribulin (clinicaltrials.gov)
    P2, N=14, Active, not recruiting, MedSIR | Recruiting --> Active, not recruiting
    Enrollment closed • First-in-human
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    HER-2 (Human epidermal growth factor receptor 2) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog)
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    HER-2 positive • HR positive • HER-2 negative • PIK3CA mutation • HR positive + HER-2 negative
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    Halaven (eribulin mesylate) • izorlisib (MEN1611)
    19d
    Study of E7386 in Participants With Selected Advanced Neoplasms (clinicaltrials.gov)
    P1, N=60, Active, not recruiting, Eisai Inc. | Trial completion date: Mar 2026 --> Mar 2027 | Trial primary completion date: Mar 2026 --> Mar 2027
    Trial completion date • Trial primary completion date
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1)
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    E7386
    23d
    A Phase II, Single-arm Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Eribulin in Pretreated Advanced Triple-negative Breast Cancer Harboring a PIK3CA Mutation (clinicaltrials.gov)
    P2, N=26, Not yet recruiting, Hu Hai
    New P2 trial
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PGR (Progesterone receptor)
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    HER-2 amplification • HER-2 negative • PIK3CA mutation • HER-2 negative + HR negative
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    Halaven (eribulin mesylate) • Itovebi (inavolisib)
    23d
    Efficacy and safety of eribulin plus gemcitabine as second-line treatment for recurrent HER2-negative breast cancer: a phase II, single-arm, open-label trial. (PubMed, Commun Med (Lond))
    Eribulin plus gemcitabine is effective and well-tolerated in patients with HER2-negative metastatic breast cancer needing second-line or later treatment, providing a valuable treatment option.
    P2 data • Journal
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    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 positive • HR positive • HER-2 negative • HR positive + HER-2 negative
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    gemcitabine • Halaven (eribulin mesylate)
    24d
    Tegavivint With Gemcitabine in Patients With Relapsed or Refractory Osteosarcoma (clinicaltrials.gov)
    P1, N=24, Recruiting, Emory University | Not yet recruiting --> Recruiting
    Enrollment open
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    gemcitabine • tegavivint (BC2059)
    26d
    E7386-J081-102: A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor (clinicaltrials.gov)
    P1/2, N=301, Active, not recruiting, Eisai Inc. | Recruiting --> Active, not recruiting | Trial completion date: Aug 2027 --> Mar 2027 | Trial primary completion date: Aug 2027 --> Mar 2027
    Enrollment closed • Trial completion date • Trial primary completion date
    |
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • MSI (Microsatellite instability)
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    BRAF V600E • MSI-H/dMMR • BRAF V600 • KRAS wild-type • NRAS wild-type
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    paclitaxel • Lenvima (lenvatinib) • doxorubicin hydrochloride • E7386
    26d
    A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC) (clinicaltrials.gov)
    P1, N=70, Active, not recruiting, Eisai Co., Ltd. | Trial completion date: Jan 2026 --> Mar 2027 | Trial primary completion date: Jan 2026 --> Mar 2027
    Trial completion date • Trial primary completion date
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    RNF43 (Ring Finger Protein 43) • APC (APC Regulator Of WNT Signaling Pathway) • AXIN1 (Axin 1) • ZNRF3 (Zinc And Ring Finger 3)
    |
    E7386
    27d
    Effects of Eribulin on Epithelial-Mesenchymal Plasticity in Patient-Derived Breast Cancer Cultures and Excised Tissues. (PubMed, Cancers (Basel))
    Our data highlight the presence of contextual parameters which govern the degree of EMT regulation by eribulin.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • CDH1 (Cadherin 1)
    |
    doxorubicin hydrochloride • Halaven (eribulin mesylate)