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    BIOMARKER:

    CAPRIN-1 expression

    i
    Other names: CAPRIN1, Cell Cycle Associated Protein 1, Caprin-1, RNG105, GPI-Anchored Membrane Protein 1, GPIAP1, M11S1, Cytoplasmic Activation- And Proliferation-Associated Protein 1, Cytoplasmic Activation/Proliferation-Associated Protein-1, Membrane Component Chromosome 11 Surface Marker 1, GPI-Anchored Protein P137, RNA Granule Protein 105, GPI-P137, GPIP137, P137GPI, Membrane Component, Chromosome 11, Surface Marker 1, Activation/Proliferation-Associated Protein 1, Cell Cycle-Associated Protein 1, Caprin 1, GRIP137
    Entrez ID:
    4076
    18d
    Cell cycle associated protein 1 associates with immune infiltration and ferroptosis in gastrointestinal cancer. (PubMed, Heliyon)
    Inhibition of CAPRIN1 expression promoted ferroptotic cell death induced by RAS-selective lethal 3 and erastin in human esophagus cancer cells. Collectively, our results demonstrate that CAPRIN1 is aberrantly expressed in gastrointestinal cancer, is associated with poor prognosis, and could potentially influence immune infiltration and ferroptosis.
    Journal
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    CAPRIN1 (Cell Cycle Associated Protein 1)
    |
    CAPRIN-1 expression
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    erastin
    5ms
    Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer. (PubMed, J Transl Med)
    Our findings establish causal links between the upregulated expression of Caprin-1 and autophagy activation, which may manipulate immune responses in PDAC development. Our study provides insights into considering Caprin-1 as potential therapeutic target for PDAC treatment.
    Journal
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    CAPRIN1 (Cell Cycle Associated Protein 1)
    |
    CAPRIN-1 expression
    5ms
    A randomized, multicenter, open-label, phase 2 study of TRK-950 in combination with ramucirumab and paclitaxel as second-line therapy in patients with CAPRIN-1 positive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma. (ASCO-GI 2024)
    4, suppl. Clinical trial information: NCT06038578.
    Clinical • P2 data • Combination therapy
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    HER-2 (Human epidermal growth factor receptor 2) • CAPRIN1 (Cell Cycle Associated Protein 1)
    |
    HER-2 positive • CAPRIN-1 expression
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    paclitaxel • Cyramza (ramucirumab) • TRK-950
    1year
    Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP. (PubMed, J Transl Med)
    Our data suggest that Caprin-1 could serve as a prognostic biomarker and has an oncogenic role in ESCA.
    Journal
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    WT1 (WT1 Transcription Factor) • CAPRIN1 (Cell Cycle Associated Protein 1) • METTL3 (Methyltransferase Like 3) • WTAP (WT1 Associated Protein)
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    CAPRIN-1 expression