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DRUG:

BT5528

i
Other names: BT5528, BT-5528, BT 5528, EphA2-MMAE peptide-drug conjugate
Associations
Company:
Bicycle Therap
Drug class:
EphA2 receptor antagonist
Associations
2ms
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression (clinicaltrials.gov)
P1/2, N=288, Recruiting, BicycleTx Limited | Trial completion date: Dec 2024 --> Oct 2026
Trial completion date
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CD4 (CD4 Molecule) • EPHA2 (EPH receptor A2)
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Opdivo (nivolumab) • BT5528
over2years
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression (clinicaltrials.gov)
P1/2, N=312, Recruiting, BicycleTx Limited | N=166 --> 312 | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
Enrollment change • Trial completion date • Trial primary completion date
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CD4 (CD4 Molecule) • EPHA2 (EPH receptor A2)
|
Opdivo (nivolumab) • BT5528
over2years
Activity of the erythropoietin-producing hepatocellular A2 receptor (EphA2) targeting Bicycle® Toxin Conjugate (BTC™) BCY6033 in EGFR inhibitor resistant non-small lung cancer (NSCLC) patient derived xenografts (AACR 2022)
Here we report on EphA2 expression in well characterized and clinically annotated patient derived xenografts (PDX) of NSCLC including EGFR mutant NSCLC derived either from erlotinib or osimertinib resistant patients. BCY6033 is a potentially promising drug effective against EphA2 expressing PDX models. Future studies and clinical trials will seek to determine the efficacy of BT5528 in EphA2 expressing tumors.
Clinical
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EPHA2 (EPH receptor A2)
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EGFR mutation
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Tagrisso (osimertinib) • erlotinib • BCY6033 • BT5528
over3years
[VIRTUAL] Rapid accumulation of cytotoxic payload in tumor tissue drives BT5528 activity in tumor models (AACR 2021)
In contrast, BT5528 achieves prolonged toxin delivery to tumors, following transient exposure in plasma of less than one hour. A Phase I/II study of BT5528 in patients with solid tumors is ongoing, which will investigate if this PK novel, differentiated pharmacokinetic profile, unique to Bicycle toxin conjugates, gives rise to a favorable balance of efficacy and safety.
Preclinical
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EPHA2 (EPH receptor A2)
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EPHA2 overexpression
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BT5528
over4years
[VIRTUAL] BT5528-100 phase I/II study of the safety, pharmacokinetics, and preliminary clinical activity of BT5528 in patients with advanced malignancies associated with EphA2 expression. (ASCO 2020)
BT5528-100 (NCT04180371) is a Ph I/II study to evaluate safety and tolerability of weekly BT5528 alone and in combination with Q4W nivolumab. Enrollment is ongoing. Research Funding: Bicycle Tx Limited
Clinical • P1/2 data • PK/PD data • PD(L)-1 Biomarker
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EGFR (Epidermal growth factor receptor) • EPHA2 (EPH receptor A2)
|
Opdivo (nivolumab) • BT5528