Brain Cancer

P3, N=200, Recruiting, NRG Oncology | Trial primary completion date: Jul 2028 --> Jun 2026

P=N/A, N=70, Active, not recruiting, Sunnybrook Health Sciences Centre | Recruiting --> Active, not recruiting

Furthermore, mathematical simulation analysis supported the notion that increased phosphorylation levels of BMAL1 and its subsequent nuclear localization could serve as a driving force for phase shifts in the circadian oscillatory system. In conclusion, our findings suggest that BMAL1-ISR acts as a key integrative "switching signal" linking diverse synchronization cues to molecular clock oscillations.

Upfront CTx only regimens used were classified into three groups to reflect disease treatment conventions: standard-dose, high-dose (intensified regimens of sufficient dosage to require stem cell support) and those including intraventricular methotrexate (IVT-MTX)...With outcomes established, clinical trials are now encouraged to focus on quality-of-life following different intensified approaches to identify the kindest curative strategies. Cancer Research UK, Children with Cancer UK, Children's Cancer North, Star for Harris, JGW Patterson Foundation, Little Hero and Blue Skye Thinking.

The calibration curves indicated good agreement and DCA confirmed the clinical utility of the model. The proposed nomogram demonstrated robust predictive performance for patients with breast cancer and liver metastases and may provide valuable prognostic information, pending further validation.

These findings suggest that HK2KD is associated with transcriptional changes extending beyond glycolytic pathways, linking metabolic activity to immunological and angiogenic transcriptional networks in a model-dependent manner. Although functional effects on the tumour microenvironment were not directly assessed, this study provides a transcriptomic framework for understanding how HK2 targeting may be associated with changes in tumour-associated signalling pathways, with potential implications for stratified metabolic and combination therapeutic strategies in glioblastoma.

This trial met safety/feasibility primary end points with some preliminary signals of efficacy. ClinicalTrials.gov registration: NCT03652545 .

Nanopore sequencing enables rapid, accurate, multidimensional molecular classification of diagnostically intractable CNS tumors using routine FFPE and frozen tissue, achieving high diagnostic resolution in comparison with reference methods while drastically reducing turnaround time and cost, making precision neuropathology feasible beyond quaternary centers.

These suggest that only βCD increases NRF2 and ROS as an adaptive response of A172 cells. The incorporation of amphiphilic dendritic groups enables efficient cellular uptake of βCD-dendronized containers.

P3, N=450, Active, not recruiting, Ivy Brain Tumor Center | Recruiting --> Active, not recruiting

P=N/A, N=9, Not yet recruiting, Huanhu Hospital Affiliated to Tianjin Medical University

However, NTRK gene aberrations are rare, necessitating FISH or next-generation sequencing confirmation for pan-TRK-positive cases to identify candidates for TRK-targeted therapy. Further studies are needed to clarify the biological role of non-fusion-mediated pan-TRK overexpression in meningioma progression.