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BIOMARKER:

BRAF V600G

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Entrez ID:

Related biomarkers:

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HER-2 amplification + RAS wild-type + BRAF wild-type (9)

BRAF V600K + LDH elevation (3)

BRAF V600E + MSI-H (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

BRAF V600E + ROS1 fusion (2)

BRAF mutation + MET amplification (2)

BRAF mutation + MSI-L/dMMR (2)

BRAF mutation + TERT overexpression (2)

BRAF wild-type + HER-2 positive (2)

EZR overexpression + BRAF V600E (2)

IDH1 mutation + BRAF V600E (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

IDH2 mutation + BRAF V600E (2)

IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

MSI-H/dMMR + BRAF V600E (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 overexpression + BRAF V600E (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF V600E + CDKN2A deletion + MYCN amplification (1)

BRAF V600E + CDKN2A deletion + RB1 expression (1)

BRAF V600E + EGFR expression (1)

BRAF V600E + PTEN deletion (1)

BRAF V600E + SOX2 amplification (1)

BRAF V600K + CDKN2A deletion + RB1 expression (1)

BRAF mutation + PD-L1 overexpression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)

BRAF wild-type + HGF elevation (1)

CD8 elevation + BRAF V600 (1)

Chr t(11;14) + BRAF mutation (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

HER-2 amplification + BRAF wild-type (1)

HR positive + BRAF V600E (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIAA1549-BRAF fusion + PTEN deletion (1)

KRAS wild-type + BRAF V600E (1)

LDH elevation + BRAF mutation (1)

MAP2K1 mutation + BRAF wild-type (1)

MSI-H/dMMR + BRAF Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

NRAS mutation + BRAF wild-type (1)

PD-L1 expression + BRAF negative (1)

PIK3CA mutation + BRAF wild-type (1)

SEMA6A overexpression + BRAF mutation (1)

SRC overexpression + BRAF V600E (1)

TNFAIP3 overexpression + BRAF mutation (1)

PD-L1 overexpression + BRAF mutation (0)

HER-2 amplification + RAS wild-type + BRAF wild-type (9)

BRAF V600K + LDH elevation (3)

BRAF V600E + MSI-H (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

BRAF V600E + ROS1 fusion (2)

BRAF mutation + MET amplification (2)

BRAF mutation + MSI-L/dMMR (2)

BRAF mutation + TERT overexpression (2)

BRAF wild-type + HER-2 positive (2)

EZR overexpression + BRAF V600E (2)

IDH1 mutation + BRAF V600E (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

IDH2 mutation + BRAF V600E (2)

IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

MSI-H/dMMR + BRAF V600E (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 overexpression + BRAF V600E (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF V600E + CDKN2A deletion + MYCN amplification (1)

BRAF V600E + CDKN2A deletion + RB1 expression (1)

BRAF V600E + EGFR expression (1)

BRAF V600E + PTEN deletion (1)

BRAF V600E + SOX2 amplification (1)

BRAF V600K + CDKN2A deletion + RB1 expression (1)

BRAF mutation + PD-L1 overexpression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)

BRAF wild-type + HGF elevation (1)

CD8 elevation + BRAF V600 (1)

Chr t(11;14) + BRAF mutation (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

HER-2 amplification + BRAF wild-type (1)

HR positive + BRAF V600E (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIAA1549-BRAF fusion + PTEN deletion (1)

KRAS wild-type + BRAF V600E (1)

LDH elevation + BRAF mutation (1)

MAP2K1 mutation + BRAF wild-type (1)

MSI-H/dMMR + BRAF Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

NRAS mutation + BRAF wild-type (1)

PD-L1 expression + BRAF negative (1)

PIK3CA mutation + BRAF wild-type (1)

SEMA6A overexpression + BRAF mutation (1)

SRC overexpression + BRAF V600E (1)

TNFAIP3 overexpression + BRAF mutation (1)

PD-L1 overexpression + BRAF mutation (0)

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over1year

Non-V600E/K BRAF Mutations in Metastatic Melanoma: Molecular Description, Frequency, and Effectiveness of Targeted Therapy in a Large National Cohort. (PubMed, JCO Precis Oncol)

Rare BRAF mutations are not anecdotal in the metastatic melanoma population. Although data interpretation must remain careful owing to the limited size of some subsets of patients, non-E/K V600 BRAF mutations seem to confer a high sensitivity to targeted therapy, whereas MAPKis seem less effective in patients with non-V600 BRAF mutations. However, this strategy may be used as an alternative option in the case of immunotherapy failure in the latter population.

over 1 year ago

Clinical • Journal • IO biomarker

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BRAF (B-raf proto-oncogene)

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BRAF V600E • BRAF V600K • BRAF V600G • BRAF V600R • BRAF K601 • BRAF L597