bleomycin

Pre-treatment biomarker levels were associated with greater KS tumor burden but not with KS response to chemotherapy + ART in people with advanced AIDS-KS. Differential levels of several serum biomarkers were noted on treatment in progressors and non-progressors, suggesting that increased tumor burden was associated with higher levels of inflammation and immune activation.

SQAP sensitized series of chemotherapeutic agents including doxorubicin, carboplatin, bleomycin, camptothecin, etoposide, methyl methanesulfonate, cisplatin, mitomycin C, and Taxol in canine tumor cells and V79 cells. These results suggest that broad inhibition of DNA repair may play a role in SQAP induced radiosensitization and chemosensitization.

Here, we will discuss the impact of diverse risk factors, including anticancer agents such as bleomycin and methotrexate; mineral silica; and metals like arsenic, aluminium and copper, which have been identified as potential triggers of pulmonary fibrosis. This review will also discuss the role of natural phytocompounds, including steroidal saponin, stilbenoid polyphenol resveratrol, safflomin of Carthamus tinctorius or safflower yellow, along with several genetic modulation approaches in addressing IPF. Finally, we examine the aspects and associations of IPF and SARS-CoV-2 to better understand disease severity, causes, and associated comorbidities.

We found that ASH ameliorated bleomycin-induced lung dysfunction and reduced lung inflammation levels, collagen deposition and Epithelial-mesenchymal transition (EMT) in mice...Notably, ASH inhibited STAT3 phosphorylation and nuclear translocation, and overexpression of STAT3 in MLE-12 cells reversed the effects of ASH on ECM deposition and cell migration. Collectively, our studies demonstrate that ASH alleviates PF through inhibition of the STAT3 signaling pathway and provide compelling evidence that ASH is a promising candidate drug for the treatment of PF.

Tumor cells (SNU-5) and healthy cells (CCL-241) exhibit no response to bare FA-HSA NPs. An analysis of the results confirmed that the formulated NPs (FA-BLM-HSA) exhibit significant therapeutic activity against gastric cancer, as indicated by their cell toxicity profile and the induction of apoptosis.

The patient underwent systemic chemotherapy with a CCABE regimen (cisplatin, cyclophosphamide, bleomycin, etoposide, and doxorubicin), followed by external beam radiotherapy using LINAC at 40 Gy/20 fractions. This case represents the first known pediatric FDCS of the parotid gland and demonstrates that a combination of systemic chemotherapy and targeted radiotherapy can achieve promising results, even in metastatic disease. Long-term follow-up is required to evaluate sustained response and monitor for recurrence or late treatment complications.

Here we introduce a single cell-PLOM-CON analysis method by combining multiplex immunofluorescence and image-based covariation network analysis and reveal several changes of proteins in early cell state changes across different cell cycle phases in HeLa cells, induced by anticancer drugs, bleomycin, cytarabine and aspirin, before any visible effects of drugs on the cell cycle appeared. Furthermore, the dynamical network biomarker theory reveals that cyclin B1 at the G2 phase is a presage protein signal of S-phase arrest induced by anticancer drugs with modes of action (MoA) similar to cytarabine. This integrated approach allows for the extraction of early protein biomarkers in initial states of drug efficacy and for drug stratification using subtle differences in MoA.

Quantitative real-time polymerase chain reaction (qRT-PCR) validation in a bleomycin-induced mouse model confirmed differential expression of the seven model genes, aligning with transcriptomic predictions. The prognostic signature based on PCD-related genes provides new biomarkers for the prognostic assessment of IPF, and has high predictive accuracy. Additionally, the identified potential drugs offer new directions for the treatment of IPF, laying the foundation for future individualized therapies.

Notably, the effect of TA at 400 mg/kg, while beneficial, was slightly less pronounced compared to the TAIC complex at the same dosage. The results revealed that TAIC hasa protective effect on BLM -induced pulmonary fibrosis.

Dna2 mutants demonstrated significant sensitivity to replication stress induced by MMS, hydroxyurea, topotecan, and nitrogen mustard. Dna2lS/S1 mutants exhibited higher survival than Dna2lS/D2 upon exposure to topotecan and bleomycin, suggesting a possible helicase-specific role in damage response...These insights clarify the nuanced contributions of the nuclease and helicase domains of DNA2, suggesting potential domain-specific functions in genomic stability and repair mechanisms. This work provides a foundation that will enable future researchers to further dissect the complex roles of DNA2 in replication and repair pathways.

Here, we report that TPI1 expression was elevated in IPF tissues and in mice with bleomycin-induced pulmonary fibrosis...Notably, we designed and tested the activity of a novel cell-penetrating peptide that increased the acetylation of TPI1 and markedly promoted TPI1 degradation, thereby effectively reducing fibrosis. Together, our findings revealed that targeting TPI1 acetylation is an effective strategy for IPF therapy, and the specific cell-penetrating peptide could prevent IPF by promoting the acetylation of TPI1.

In the bleomycin-induced lung fibrosis model of Il7rfl/fl Csf1r-iCre mice, macrophage expression of Spp1 and Gpnmb was reduced, and lung fibrosis was attenuated, compared with those of Il7rfl/fl mice. These profibrotic Spp1-producing macrophages and the IL-7/macrophage/Spp1 axis may represent therapeutic targets for lung fibrosis.