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    DRUG:

    bisindolylmaleimide IX (RO-31-8220)

    i
    Other names: RO-31-8220, RO-318220, RO 31-8220
    Company:
    Roche
    Drug class:
    PKC inhibitor
    Related drugs:
    almost2years
    SS18-SSX drives CREB activation in synovial sarcoma. (PubMed, Cell Oncol (Dordr))
    In conclusion, our data underline an essential role of CREB in SySa tumorigenesis and provides evidence for molecular targeted therapies.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • BCL2L1 (BCL2-like 1) • PCNA (Proliferating cell nuclear antigen) • SS18 (SS18 Subunit Of BAF Chromatin Remodeling Complex)
    |
    SS18-SSX fusion
    |
    BMS-754807 • bisindolylmaleimide IX (RO-31-8220)