BET inhibitor

In bacillus Calmette-Guérin-vaccinated subjects and those with latent TB infection, T were marked by the production of IFN-γ but not TNF-α and identified by the absence of CD95 expression and increased surface expression CCR7, CD27, the activation markers T-bet, CD69, and the survival marker CD74...Importantly, adoptive transfer of highly purified T alone, from vaccinated ESAT-6-specific TCR transgenic mice, conferred equivalent protection against M. tuberculosis infection in the lungs of Rag mice when compared with total memory populations (central and effector memory cells). Thus, T may represent a memory T cell population that, if optimally targeted, may significantly improve future TB vaccine responses.