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9ms
GT90001 Plus Nivolumab in Patients With Advanced Hepatocellular Carcinoma (clinicaltrials.gov)
P2, N=5, Active, not recruiting, Suzhou Kintor Pharmaceutical Inc, | Recruiting --> Active, not recruiting | N=105 --> 5 | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Jun 2023 --> Apr 2025
Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Metastases
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Opdivo (nivolumab) • ascrinvacumab (GT90001)
9ms
A Phase Ib/II Study of GT90001 Combined With KN046 in Solid Tumors (clinicaltrials.gov)
P1/2, N=216, Recruiting, Suzhou Kintor Pharmaceutical Inc, | Trial completion date: Sep 2025 --> Dec 2025 | Trial primary completion date: Sep 2024 --> Apr 2025
Trial completion date • Trial primary completion date • Combination therapy • Metastases
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PD-L1 (Programmed death ligand 1)
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PD-L1 expression
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erfonrilimab (KN046) • ascrinvacumab (GT90001)
9ms
Combination of GT90001 and Nivolumab in Patients With Metastatic Hepatocellular Carcinoma(HCC) (clinicaltrials.gov)
P1/2, N=20, Completed, Suzhou Kintor Pharmaceutical Inc, | Active, not recruiting --> Completed
Trial completion
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Opdivo (nivolumab) • ascrinvacumab (GT90001)
almost3years
A Phase Ib/II Study of GT90001 Combined With KN046 in Solid Tumors (clinicaltrials.gov)
P1/2, N=216, Recruiting, Suzhou Kintor Pharmaceutical Inc, | Not yet recruiting --> Recruiting
Clinical • Enrollment open • Combination therapy
|
PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
|
erfonrilimab (KN046) • ascrinvacumab (GT90001)
over3years
A Phase Ib/II Study of GT90001 Combined With KN046 in Solid Tumors (clinicaltrials.gov)
P1/2, N=216, Not yet recruiting, Suzhou Kintor Pharmaceutical Inc,
New P1/2 trial
|
PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
|
erfonrilimab (KN046) • ascrinvacumab (GT90001)
over3years
Combination of GT90001 and Nivolumab in Patients With Metastatic Hepatocellular Carcinoma(HCC) (clinicaltrials.gov)
P1/2, N=20, Active, not recruiting, Suzhou Kintor Pharmaceutical Inc, | Trial completion date: Jun 2021 --> Jun 2022 | Trial primary completion date: Jun 2021 --> Jun 2022
Clinical • Trial completion date • Trial primary completion date
|
TGFB1 (Transforming Growth Factor Beta 1)
|
Opdivo (nivolumab) • ascrinvacumab (GT90001)
over3years
PF-03446962 in Relapsed or Refractory Urothelial Cancer (clinicaltrials.gov)
P2, N=14, Completed, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | N=45 --> 14
Clinical • Enrollment change
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EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PTEN (Phosphatase and tensin homolog) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • IL6 (Interleukin 6) • FLT1 (Fms-related tyrosine kinase 1)
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ascrinvacumab (GT90001)
almost4years
[VIRTUAL] Safety and efficacy of combination of GT90001, an anti-activin receptor-like kinase-1 (ALK-1) antibody, and nivolumab in patients with metastatic hepatocellular carcinoma (HCC). (ASCO-GI 2021)
This study aimed to assess the safety and efficacy of GT90001 in combination with nivolumab in patients with advanced HCC who had progressive disease after or were intolerant to first-line sorafenib or lenvatinib therapy (NCT03893695). The combination of GT90001 with nivolumab showed a manageable safety profile, and no new safety signals were identified. The promising preliminary antitumor activities show the potential of GT90001 combined with nivolumab as second-line treatment for advanced HCC.
Clinical
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ALK1 (Activin A Receptor Like Type 1)
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Opdivo (nivolumab) • sorafenib • Lenvima (lenvatinib) • ascrinvacumab (GT90001)