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    DRUG:

    ART0380

    i
    Other names: ART0380, ART 0380, IACS-030380
    Associations

    News

    Trials
    Company:
    Artios Pharma
    Drug class:
    ATR inhibitor
    Related drugs:
    Associations

    News

    Trials
    3ms
    Ataxia-Telangiectasia Mutated (ATM) loss of function displays variant and tissue-specific differences across tumor types. (PubMed, Clin Cancer Res)
    These data help to better define ATM LOF across tumor types in order to optimize patient selection and improve molecularly targeted therapeutic approaches for patients with ATM LOF cancers.
    Journal
    |
    ATM (ATM serine/threonine kinase)
    |
    ATM mutation
    |
    ART0380
    3ms
    A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors (clinicaltrials.gov)
    P1/2, N=372, Recruiting, Artios Pharma Ltd | N=242 --> 372
    Enrollment change • Metastases
    |
    ATM (ATM serine/threonine kinase) • HRD (Homologous Recombination Deficiency) • BRCA (Breast cancer early onset)
    |
    HRD • BRCA mutation
    |
    gemcitabine • irinotecan • ART0380
    9ms
    ARTIST: Study of ART0380 in Advanced/Metastatic Solid Tumors Patients (clinicaltrials.gov)
    P2, N=60, Recruiting, Artios Pharma Ltd | Not yet recruiting --> Recruiting | Initiation date: Apr 2023 --> Sep 2023
    Enrollment open • Trial initiation date • Pan tumor • Metastases
    |
    PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1)
    |
    ART0380
    1year
    ARTIST: Study of ART0380 in Advanced/Metastatic Solid Tumors Patients (clinicaltrials.gov)
    P2, N=60, Not yet recruiting, Artios Pharma Ltd
    New P2 trial • Pan tumor • Metastases
    |
    PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1)
    |
    ART0380
    1year
    A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors (clinicaltrials.gov)
    P1/2, N=242, Recruiting, Artios Pharma Ltd | Trial completion date: Dec 2023 --> Jun 2025 | Trial primary completion date: Dec 2023 --> Jun 2025
    Trial completion date • Trial primary completion date • Metastases
    |
    ATM (ATM serine/threonine kinase) • HRD (Homologous Recombination Deficiency) • BRCA (Breast cancer early onset)
    |
    HRD • BRCA mutation
    |
    gemcitabine • irinotecan • ART0380
    over3years
    A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors (clinicaltrials.gov)
    P1/2, N=180, Recruiting, Artios Pharma Ltd | Not yet recruiting --> Recruiting
    Clinical • Enrollment open
    |
    ATM (ATM serine/threonine kinase) • HRD (Homologous Recombination Deficiency) • BRCA (Breast cancer early onset)
    |
    HRD • BRCA mutation
    |
    gemcitabine • ART0380
    over3years
    A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors (clinicaltrials.gov)
    P1/2, N=180, Not yet recruiting, Artios Pharma Ltd
    Clinical • New P1/2 trial
    |
    ATM (ATM serine/threonine kinase) • HRD (Homologous Recombination Deficiency) • BRCA (Breast cancer early onset)
    |
    HRD • BRCA mutation
    |
    gemcitabine • ART0380