^
    9ms
    Effect and mechanism of acupuncture on airway smooth muscle relaxation during acute asthma attack in rats. (PubMed, Zhongguo Zhen Jiu)
    Acupuncture at "Feishu" (BL 13) and "Dingchuan" (EX-B 1), "Kongzui" (LU 6) and "Yuji" (LU 10), two pairs of acupoints relieves the airway smooth muscle spasm in the rats during acute asthma attack, which may be related to inhibiting the mRNA and protein expression of ET-1 to reduce the excretion of ET-1 and TNF-α; while enhancing the mRNA and protein expression of β2-AR to balance the levels of cAMP and cGMP. The effect is optimal when acupuncture is delivered at two pairs of acupoints simultaneously.
    Preclinical • Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha)
    |
    AR elevation
    over3years
    MAP3K7-IKK inflammatory signaling modulates AR protein degradation and prostate cancer progression. (PubMed, Cancer Res)
    These findings reveal a previously unrecognized tumor suppressive function of the inflammation-activated MAP3K7-IKKβ axis in degrading AR protein. Moreover, they suggest that aberrant elevation of AR protein could be a prognostic biomarker and therapeutic target for MAP3K7-deficient PCa.
    Journal
    |
    AR (Androgen receptor)
    |
    AR elevation