^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG:

    anti TROP-2 antibody therapeutic

    i
    Other names: anti TROP-2 antibody therapeutic
    Associations

    News

    Trials
    Company:
    Roche
    Drug class:
    TROP-2-targeted antibody-drug conjugate
    Related drugs:
    Associations

    News

    Trials
    over3years
    Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer. (PubMed, Neoplasia)
    Recently, the anti-Trop-2 mAb Sacituzumab govitecan-hziy was shown to be active against metastatic breast cancer. Our findings define the key relevance of Trop-2 as a target in metastatic colon cancer.
    Journal
    |
    CDH1 (Cadherin 1)
    |
    CDH1 mutation
    |
    Trodelvy (sacituzumab govitecan-hziy) • anti TROP-2 antibody therapeutic