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    DRUG:

    ADG106

    i
    Other names: ADG106, ADG 106, ADG-106
    Associations

    News

    Trials
    Company:
    Adagene
    Drug class:
    CD137 agonist
    Related drugs:
    Associations

    News

    Trials
    3ms
    Preclinical characterization and phase 1 results of ADG106 in patients with advanced solid tumors and non-Hodgkin's lymphoma. (PubMed, Cell Rep Med)
    Circulating biomarkers suggest target engagement by ADG106 and immune modulation of circulating T, B, and natural killer cells and cytokines interferon γ and interleukin-6, which may affect the probability of clinical efficacy. ADG106 has a manageable safety profile and preliminary anti-tumor efficacy in patients with advanced cancers (this study was registered at ClinicalTrials.gov: NCT03802955).
    P1 data • Preclinical • Journal • IO biomarker • Metastases
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFRSF9 (TNF Receptor Superfamily Member 9)
    |
    ADG106
    3ms
    ADG116-1003: A Phase 1b/2 Study of ADG116, ADG116 Combined With Anti-PD-1 Antibody or Anti-CD137 Antibody in Solid Tumors Patients (clinicaltrials.gov)
    P1, N=72, Active, not recruiting, Adagene Inc | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    Loqtorzi (toripalimab-tpzi) • ADG106
    10ms
    ComPACT: Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast Cancer (clinicaltrials.gov)
    P1b, N=51, Recruiting, National University Hospital, Singapore | Not yet recruiting --> Recruiting
    Enrollment open • Metastases
    |
    Keytruda (pembrolizumab) • ADG106
    1year
    ADG106-1002: Study of ADG106 With Advanced or Metastatic Solid Tumors and/or Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=62, Completed, Adagene (Suzhou) Limited | Active, not recruiting --> Completed
    Trial completion • Metastases
    |
    IL6 (Interleukin 6) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • IL4 (Interleukin 4)
    |
    ADG106
    over1year
    ADG106-1002: Study of ADG106 With Advanced or Metastatic Solid Tumors and/or Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=62, Active, not recruiting, Adagene (Suzhou) Limited | Trial completion date: Aug 2022 --> Dec 2022
    Trial completion date • Metastases
    |
    IL6 (Interleukin 6) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • IL4 (Interleukin 4)
    |
    ADG106
    almost2years
    ADG106-1002: Study of ADG106 With Advanced or Metastatic Solid Tumors and/or Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=62, Active, not recruiting, Adagene (Suzhou) Limited | Trial completion date: Mar 2022 --> Aug 2022 | Trial primary completion date: Feb 2022 --> Nov 2021
    Trial completion date • Trial primary completion date
    |
    IL6 (Interleukin 6) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • IL4 (Interleukin 4)
    |
    ADG106
    over2years
    ADG106-1002: Study of ADG106 With Advanced or Metastatic Solid Tumors and/or Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=62, Active, not recruiting, Adagene (Suzhou) Limited | Trial primary completion date: Aug 2021 --> Feb 2022
    Trial primary completion date
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • IL4 (Interleukin 4)
    |
    ADG106
    3years
    ADG106-1002: Study of ADG106 With Advanced or Metastatic Solid Tumors and/or Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=62, Active, not recruiting, Adagene (Suzhou) Limited | Recruiting --> Active, not recruiting | N=24 --> 62 | Trial primary completion date: Apr 2021 --> Aug 2021
    Clinical • Enrollment closed • Enrollment change • Trial primary completion date
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • IL4 (Interleukin 4)
    |
    ADG106
    over3years
    ADG106-1002: Study of ADG106 With Advanced or Metastatic Solid Tumors and/or Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=24, Recruiting, Adagene (Suzhou) Limited | Trial primary completion date: Dec 2020 --> Apr 2021
    Clinical • Trial primary completion date
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL2 (Interleukin 2) • IL10 (Interleukin 10) • IL4 (Interleukin 4)
    |
    ADG106