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    DRUG:

    ACE1831

    i
    Other names: ACE1831, ACE-NgdT-CD20, CD20 targeting ACC-gamma delta T cell therapy, CD20 targeting ACC-γδ T cell therapy, anti-CD20 conjugated NgdT cells, ACE-1831, ACE 1831
    Associations

    News

    Trials
    Company:
    Acepodia
    Drug class:
    CD20 inhibitor, γδ TCR modulator
    Related drugs:
    Associations

    News

    Trials
    almost2years
    ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies (clinicaltrials.gov)
    P1, N=42, Recruiting, Acepodia Biotech, Inc. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    CD20 (Membrane Spanning 4-Domains A1)
    |
    CD20 positive
    |
    Gazyva (obinutuzumab) • cyclophosphamide • fludarabine IV • ACE1831
    almost2years
    ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies (clinicaltrials.gov)
    P1, N=42, Not yet recruiting, Acepodia Biotech, Inc.
    New P1 trial
    |
    CD20 (Membrane Spanning 4-Domains A1)
    |
    CD20 positive
    |
    Gazyva (obinutuzumab) • cyclophosphamide • fludarabine IV • ACE1831
    over2years
    ACE1831: A novel allogeneic αCD20-conjugated Vδ2 gamma delta T product for non-Hodgkin’s lymphoma (AACR 2022)
    At 72 hours, specific lysis was 35%; however, in combination with obinutuzumab (1,000 ng/mL), ACE1831 provided 95% specific lysis against Raji cells. Specifically, this product candidate can offer high levels of anti-tumor activity that is extended with soluble antibody using native Fc receptor expression, and may have a low risk of GvHD and IL-6 related toxicity. These data support future clinical studies in this setting.
    PD(L)-1 Biomarker • IO biomarker
    |
    CD20 (Membrane Spanning 4-Domains A1) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD69 (CD69 Molecule) • IL2 (Interleukin 2) • NCAM1 (Neural cell adhesion molecule 1) • IL10 (Interleukin 10) • CSF2 (Colony stimulating factor 2) • IL4 (Interleukin 4) • NKG2D (killer cell lectin like receptor K1)
    |
    CSF2 elevation
    |
    Gazyva (obinutuzumab) • ACE1831