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DRUG:

ABP 206 (nivolumab biosimilar)

i
Other names: ABP 206
Associations
Company:
Amgen
Drug class:
PD1 inhibitor
Related drugs:
Associations
3d
New P2 trial • Mismatch repair
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Opdivo (nivolumab) • relatlimab (BMS-986016) • ABP 206 (nivolumab biosimilar)
6d
New P1 trial • Combination therapy • Metastases
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Opdivo (nivolumab) • Yervoy (ipilimumab) • ABP 206 (nivolumab biosimilar) • Cdactin-O (CBM588)
10d
Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma (clinicaltrials.gov)
P1, N=32, Suspended, National Cancer Institute (NCI) | Trial completion date: May 2024 --> May 2025 | Trial primary completion date: May 2024 --> May 2025
Trial completion date • Trial primary completion date
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Opdivo (nivolumab) • Rituxan (rituximab) • lenalidomide • methotrexate • ABP 206 (nivolumab biosimilar) • Mabtas (rituximab biosimilar)
20d
DREAMseq: Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma (clinicaltrials.gov)
P3, N=300, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Jun 2024 --> Dec 2024 | Trial primary completion date: Jun 2024 --> Dec 2024
Trial completion date • Trial primary completion date • Metastases
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BRAF mutation • BRAF V600
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THXID® BRAF Kit • cobas® 4800 BRAF V600 Mutation Test
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Opdivo (nivolumab) • Mekinist (trametinib) • Yervoy (ipilimumab) • Tafinlar (dabrafenib) • ABP 206 (nivolumab biosimilar)
21d
SWOG S1826: Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma (clinicaltrials.gov)
P3, N=995, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Dec 2032 --> Apr 2025 | Trial primary completion date: Jun 2023 --> Mar 2024
Trial completion date • Trial primary completion date • Metastases
|
Opdivo (nivolumab) • doxorubicin hydrochloride • Adcetris (brentuximab vedotin) • dacarbazine • vinblastine • Neulasta (pegfilgrastim) • ABP 206 (nivolumab biosimilar) • Neupogen (filgrastim)
27d
Testing the Addition of the Pill Chemotherapy, Cabozantinib, to the Standard Immune Therapy Nivolumab Compared to Standard Chemotherapy for Non-small Cell Lung Cancer (clinicaltrials.gov)
P2, N=117, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Jun 2024 --> Sep 2024 | Trial primary completion date: Jun 2024 --> Sep 2024
Trial completion date • Trial primary completion date
|
EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
|
KRAS G12C • EGFR L858R • EGFR exon 19 deletion • EGFR exon 20 insertion • ALK rearrangement • EGFR L861Q • ROS1 positive • KRAS G12 • EGFR exon 20 mutation • MET positive • EGFR negative
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Opdivo (nivolumab) • gemcitabine • docetaxel • Cabometyx (cabozantinib tablet) • albumin-bound paclitaxel • Cyramza (ramucirumab) • Cometriq (cabozantinib capsule) • ABP 206 (nivolumab biosimilar)
27d
Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer (clinicaltrials.gov)
P3, N=344, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Aug 2024 --> Dec 2025 | Trial primary completion date: Aug 2024 --> Dec 2025
Trial completion date • Trial primary completion date
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IFNG (Interferon, gamma) • CD4 (CD4 Molecule)
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Opdivo (nivolumab) • ABP 206 (nivolumab biosimilar)
27d
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, The PARAMMUNE Trial (clinicaltrials.gov)
P2/3, N=224, Not yet recruiting, National Cancer Institute (NCI) | Initiation date: Mar 2024 --> Jun 2024
Trial initiation date • Metastases
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Opdivo (nivolumab) • paclitaxel • Cyramza (ramucirumab) • ABP 206 (nivolumab biosimilar)
1m
A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden (clinicaltrials.gov)
P2; Trial completion date: May 2024 --> May 2025 | Trial primary completion date: May 2024 --> May 2025
Checkpoint inhibition • Trial completion date • Trial primary completion date • Tumor mutational burden • IO biomarker • Checkpoint block
|
EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • TERT (Telomerase Reverse Transcriptase) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • ATRX (ATRX Chromatin Remodeler)
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TP53 mutation • EGFR mutation • EGFR amplification • CDKN2A deletion • TERT mutation • IDH wild-type • TERT promoter mutation
|
FoundationOne® CDx
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Opdivo (nivolumab) • Yervoy (ipilimumab) • ABP 206 (nivolumab biosimilar)
1m
Trial completion date • IO biomarker • Metastases
|
PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CD4 (CD4 Molecule) • FOXP3 (Forkhead Box P3)
|
PD-L1 expression • PD-1 expression
|
Opdivo (nivolumab) • ABP 206 (nivolumab biosimilar)
1m
Trial completion date • Combination therapy • Metastases
|
PD-1 (Programmed cell death 1)
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • ABP 206 (nivolumab biosimilar)
2ms
New P2 trial
|
Opdivo (nivolumab) • lomustine • relatlimab (BMS-986016) • ABP 206 (nivolumab biosimilar)
2ms
Trial suspension • Tumor mutational burden • IO biomarker • Metastases
|
TMB (Tumor Mutational Burden) • CD68 (CD68 Molecule)
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Cabometyx (cabozantinib tablet) • ABP 206 (nivolumab biosimilar)
2ms
Phase classification • Tumor cell
|
Signatera™
|
Opdivo (nivolumab) • relatlimab (BMS-986016) • ABP 206 (nivolumab biosimilar)
2ms
Enrollment open
|
ABP 206 (nivolumab biosimilar) • nivolumab subcutaneous (BMS-986298)
2ms
NRG-BN007: Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma (clinicaltrials.gov)
P2/3, N=147, Active, not recruiting, National Cancer Institute (NCI) | N=485 --> 147 | Trial completion date: Aug 2024 --> Mar 2025 | Trial primary completion date: Aug 2024 --> Apr 2023
Enrollment change • Trial completion date • Trial primary completion date • Tumor mutational burden
|
PD-L1 (Programmed death ligand 1) • TMB (Tumor Mutational Burden) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • MGMT (6-O-methylguanine-DNA methyltransferase)
|
PD-L1 expression • MGMT promoter methylation • IDH1 R132H • IDH1 R132 • MGMT expression
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • temozolomide • ABP 206 (nivolumab biosimilar)
2ms
Enrollment open • Combination therapy • Tumor mutational burden • Surgery
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • ABP 206 (nivolumab biosimilar)
2ms
Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery (clinicaltrials.gov)
P2, N=99, Recruiting, National Cancer Institute (NCI) | Suspended --> Recruiting
Enrollment open • Surgery
|
PD-L1 (Programmed death ligand 1)
|
Opdivo (nivolumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • ABP 206 (nivolumab biosimilar)
2ms
Testing Nivolumab in Combination With Decitabine and Venetoclax in Patients With Newly Diagnosed TP53 Gene Mutated Acute Myeloid Leukemia (clinicaltrials.gov)
P1, N=13, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Feb 2024 --> Feb 2025 | Trial primary completion date: Feb 2024 --> Feb 2025
Trial completion date • Trial primary completion date • Combination therapy • Tumor mutational burden
|
TP53 (Tumor protein P53)
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TP53 mutation
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Opdivo (nivolumab) • Venclexta (venetoclax) • decitabine • ABP 206 (nivolumab biosimilar)
2ms
Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer (clinicaltrials.gov)
P2, N=27, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Jan 2024 --> Sep 2024 | Trial primary completion date: Jan 2024 --> Sep 2024
Trial completion date • Trial primary completion date • Combination therapy • IO biomarker • Metastases
|
PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1)
|
PD-L1 expression
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • ABP 206 (nivolumab biosimilar)
2ms
Enrollment change • Trial withdrawal
|
Opdivo (nivolumab) • Venclexta (venetoclax) • Rituxan (rituximab) • ABP 206 (nivolumab biosimilar) • Mabtas (rituximab biosimilar)
3ms
Trial initiation date • Metastases
|
PD-L1 (Programmed death ligand 1)
|
PD-L1 expression
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • ABP 206 (nivolumab biosimilar)
3ms
Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer (clinicaltrials.gov)
P2, N=137, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Feb 2024 --> Feb 2025 | Trial primary completion date: Feb 2024 --> Feb 2025
Trial completion date • Trial primary completion date • Combination therapy • Metastases
|
CD4 (CD4 Molecule)
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Opdivo (nivolumab) • Yervoy (ipilimumab) • ABP 206 (nivolumab biosimilar)
3ms
Cabozantinib S-malate and Nivolumab in Treating Patients With Advanced, Recurrent, or Metastatic Endometrial Cancer (clinicaltrials.gov)
P2, N=84, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
Trial completion date • Trial primary completion date • Combination therapy • Metastases
|
Opdivo (nivolumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • ABP 206 (nivolumab biosimilar)
3ms
New P2 trial
|
ABP 206 (nivolumab biosimilar) • nivolumab subcutaneous (BMS-986298)
3ms
Trial initiation date • Tumor cell
|
Signatera™
|
Opdivo (nivolumab) • relatlimab (BMS-986016) • ABP 206 (nivolumab biosimilar)
3ms
Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma (clinicaltrials.gov)
P1, N=32, Suspended, National Cancer Institute (NCI) | Recruiting --> Suspended
Trial suspension
|
Opdivo (nivolumab) • Rituxan (rituximab) • lenalidomide • methotrexate • ABP 206 (nivolumab biosimilar) • Mabtas (rituximab biosimilar) • methotrexate IV
3ms
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, The PARAMMUNE Trial (clinicaltrials.gov)
P2/3, N=224, Not yet recruiting, National Cancer Institute (NCI) | Initiation date: Jun 2024 --> Mar 2024
Trial initiation date • Metastases
|
Opdivo (nivolumab) • paclitaxel • Cyramza (ramucirumab) • ABP 206 (nivolumab biosimilar)
3ms
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors (clinicaltrials.gov)
P2, N=224, Recruiting, National Cancer Institute (NCI) | Trial completion date: Feb 2024 --> Feb 2025 | Trial primary completion date: Feb 2024 --> Feb 2025
Trial completion date • Trial primary completion date
|
PD-L1 (Programmed death ligand 1) • CD4 (CD4 Molecule)
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • ABP 206 (nivolumab biosimilar)
3ms
NCI10208: Testing the Combination of Anetumab Ravtansine With Either Nivolumab, Nivolumab and Ipilimumab, or Gemcitabine and Nivolumab in Advanced Pancreatic Cancer (clinicaltrials.gov)
P1, N=74, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Jan 2024 --> Jan 2025 | Trial primary completion date: Jan 2024 --> Jan 2025
Trial completion date • Trial primary completion date • Combination therapy • Tumor mutational burden • Metastases
|
MSLN (Mesothelin)
|
MSLN expression • MSLN positive
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • gemcitabine • anetumab ravtansine (BAY 94-9343) • ABP 206 (nivolumab biosimilar)
3ms
ED-SCLC: Cisplatin/Carboplatin and Etoposide With or Without Nivolumab in Treating Patients With Extensive Stage Small Cell Lung Cancer (clinicaltrials.gov)
P2, N=160, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Dec 2023 --> Dec 2024
Trial completion date • Combination therapy • IO biomarker
|
PD-L1 expression
|
Opdivo (nivolumab) • cisplatin • carboplatin • etoposide IV • ABP 206 (nivolumab biosimilar)
3ms
Trial completion date
|
PD-L1 (Programmed death ligand 1)
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • ABP 206 (nivolumab biosimilar)
3ms
New P2 trial
|
Opdivo (nivolumab) • Venclexta (venetoclax) • Rituxan (rituximab) • ABP 206 (nivolumab biosimilar) • Mabtas (rituximab biosimilar)
3ms
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV (clinicaltrials.gov)
P1, N=18, Active, not recruiting, National Cancer Institute (NCI) | Recruiting --> Active, not recruiting
Enrollment closed
|
CD276 (CD276 Molecule) • VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1) • CD4 (CD4 Molecule) • HHLA2 (HERV-H LTR-Associating 2)
|
Opdivo (nivolumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • ABP 206 (nivolumab biosimilar)
3ms
REMAIN: Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer (clinicaltrials.gov)
P2, N=156, Recruiting, National Cancer Institute (NCI) | Not yet recruiting --> Recruiting | Initiation date: Feb 2024 --> Oct 2024
Enrollment open • Trial initiation date • Metastases
|
PD-L1 (Programmed death ligand 1) • LAG3 (Lymphocyte Activating 3)
|
Opdivo (nivolumab) • cisplatin • carboplatin • gemcitabine • relatlimab (BMS-986016) • ABP 206 (nivolumab biosimilar)
4ms
Enrollment open • Trial initiation date • Tumor cell
|
Signatera™
|
Opdivo (nivolumab) • relatlimab (BMS-986016) • ABP 206 (nivolumab biosimilar)
4ms
Enrollment open • Tumor mutational burden • Metastases
|
Opdivo (nivolumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • ABP 206 (nivolumab biosimilar)
4ms
New P2/3 trial • Metastases
|
Opdivo (nivolumab) • paclitaxel • Cyramza (ramucirumab) • ABP 206 (nivolumab biosimilar)
4ms
NCI-2018-01560: Nivolumab and Multi-fraction Stereotactic Radiosurgery With or Without Ipilimumab in Treating Patients With Recurrent Grade II-III Meningioma (clinicaltrials.gov)
P1/2, N=38, Suspended, National Cancer Institute (NCI) | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
Trial completion date • Trial primary completion date • Combination therapy • Tumor mutational burden • Surgery
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • ABP 206 (nivolumab biosimilar)
4ms
Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN (clinicaltrials.gov)
P1/2, N=102, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
Trial completion date • Trial primary completion date • Checkpoint inhibition • IO biomarker • Metastases
|
PD-L1 (Programmed death ligand 1) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog)
|
PIK3CA mutation • PTEN mutation • PIK3CA E545 • PIK3CA H1047 • PIK3CA E542
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • Aliqopa (copanlisib) • ABP 206 (nivolumab biosimilar)
4ms
Trial initiation date • Combination therapy
|
Opdivo (nivolumab) • cisplatin • gemcitabine • ABP 206 (nivolumab biosimilar)
5ms
Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery (clinicaltrials.gov)
P2, N=99, Suspended, National Cancer Institute (NCI) | Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
Trial completion date • Trial primary completion date • Surgery
|
PD-L1 (Programmed death ligand 1)
|
Opdivo (nivolumab) • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule) • ABP 206 (nivolumab biosimilar)