BIOMARKER:

VHL mutation

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VHL mutation	Neuroendocrine Tumor	VHL mutation	Neuroendocrine Tumor	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1
VHL mutation	CNS Tumor	VHL mutation	CNS Tumor	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1
VHL mutation	Renal Cell Carcinoma	VHL mutation	Renal Cell Carcinoma	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1	belzutifan Sensitive: A1 - Approval belzutifan Sensitive : A1
VHL mutation	Clear Cell Renal Cell Carcinoma	VHL mutation	Clear Cell Renal Cell Carcinoma	belzutifan Sensitive: C1 - Off-label belzutifan Sensitive : C1	belzutifan Sensitive: C1 - Off-label belzutifan Sensitive : C1
VHL mutation	Glioblastoma	VHL mutation	Glioblastoma	belzutifan Sensitive: C1 - Off-label belzutifan Sensitive : C1	belzutifan Sensitive: C1 - Off-label belzutifan Sensitive : C1
VHL mutation	Clear Cell Renal Cell Carcinoma	VHL mutation	Clear Cell Renal Cell Carcinoma	PT2385 Sensitive: C2 – Inclusion Criteria PT2385 Sensitive : C2	PT2385 Sensitive: C2 – Inclusion Criteria PT2385 Sensitive : C2
VHL mutation	Neuroendocrine Tumor	VHL mutation	Neuroendocrine Tumor	PT2385 Sensitive: C3 – Early Trials PT2385 Sensitive : C3	PT2385 Sensitive: C3 – Early Trials PT2385 Sensitive : C3
VHL mutation	Clear Cell Renal Cell Carcinoma	VHL mutation	Clear Cell Renal Cell Carcinoma	pazopanib Resistant: C3 – Early Trials pazopanib Resistant : C3	pazopanib Resistant: C3 – Early Trials pazopanib Resistant : C3
VHL mutation	Renal Cell Carcinoma	VHL mutation	Renal Cell Carcinoma	everolimus Sensitive: C3 – Early Trials everolimus Sensitive : C3	everolimus Sensitive: C3 – Early Trials everolimus Sensitive : C3
VHL mutation	Clear Cell Renal Cell Carcinoma	VHL mutation	Clear Cell Renal Cell Carcinoma	VEGFR inhibitor Sensitive: C3 – Early Trials VEGFR inhibitor Sensitive : C3	VEGFR inhibitor Sensitive: C3 – Early Trials VEGFR inhibitor Sensitive : C3
VHL mutation	Cholangiocarcinoma	VHL mutation	Cholangiocarcinoma	sunitinib Sensitive: C4 – Case Studies sunitinib Sensitive : C4	sunitinib Sensitive: C4 – Case Studies sunitinib Sensitive : C4
VHL mutation	Renal Cell Carcinoma	VHL mutation	Renal Cell Carcinoma	doxorubicin hydrochloride Sensitive: D – Preclinical doxorubicin hydrochloride Sensitive : D	doxorubicin hydrochloride Sensitive: D – Preclinical doxorubicin hydrochloride Sensitive : D