When examined in relation to clinical outcome, VHL mutation and/or methylation status did not correlate with either ORR (ORR 37.5% vs. 41.4% in patients with VHL [n=70] vs. without VHL gene inactivation [n=8], respectively; Table 1) or PFS (median PFS was 13.8 months vs. 17.4 months in patients with vs. without VHL gene inactivation, respectively...