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Association details:
| Biomarker: | VHL deletion |
|---|---|
| Cancer: | Clear Cell Renal Cell Carcinoma |
| Drug: | berzosertib (M6620) (ATR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
LB039 / 11 - VHL-deficient renal cell carcinoma displays defective ATM activation and sensitivity to ATR inhibition
Published date:
03/09/2022
Excerpt:
Clear cell renal cell carcinoma (ccRCC)...DDR functional assays and ATR inhibitor treatment were performed on preclinical cell line models, and in vivo ATR inhibitor treatment in ccRCC xenografts with varying VHL status...treatment with ATRi (VE-822)...significantly inhibited tumor growth preferentially in the 786-O VHL null model.
