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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

Selinexor improves the anti-cancer effect of tucidinostat on TP53 wild-type breast cancer

Published date:
04/05/2022
Excerpt:
Results showed that both tucidinostat and selinexor showed better inhibitory activities on wt-TP53 BC (MCF-7 and MDA-MB-175) comparing with mut-TP53 BC (MDA-MB-134 and T47D). Tucidinostat combined with selinexor significantly improved the effects of tucidinostat alone on the proliferation and invasion inhibitions and apoptosis promotions of MCF-7 and MDA-MB-175 cells in vitro.
DOI:
10.1016/j.mce.2022.111558