In this model lung adenocarcinomas are induced by intranasal administration of adenoviral Cre, which causes the concomitant expression of a single KrasG12D allele and loss of p53...Neither rapamycin nor IPI-504 induced tumor regression alone; however, combined rapamycin/IPI-504 treatment resulted in dramatic tumor shrinkage (Figure 6A). 6/8 mice exhibited this potent response and individual responding masses shrunk up to 82% as determined by MRI analysis.