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BIOMARKER:
TMB-L
i
Other names:
TMB | Tumor Mutational Burden
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Related biomarkers:
Expression
Others
‹
TMB-H (186)
MSI-H/dMMR + TMB-H (8)
TMB-H + PD-L1 overexpression (7)
MSI-H/dMMR + TMB-L (5)
BRCA1 mutation + TMB-H (3)
KMT2D mutation + TMB-H (3)
MLL3 mutation + TMB-H (3)
MSI-H/dMMR + TMB-H + PD-L1 negative (3)
PD-L1 expression + TMB-H (3)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)
HER-2 expression + TMB-H (2)
LRP1B mutation + TMB-H (2)
MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)
NCOR2-NTRK1 fusion + TMB-H (2)
PAPPA2 mutation + TMB-H (2)
PD-L1 expression + TMB-H + FANCA deletion (2)
STK11 mutation + TMB-H (2)
TMB-H + EGFR exon 19 deletion (2)
TMB-H + EGFR mutation (2)
TMB-H + HER-2 positive (2)
TMB-H + PD-L1 negative (2)
TMB-H + PD-L1 underexpression (2)
TMB-H + PIK3CA mutation (2)
TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)
TMB-L + PD-L1 expression (2)
AHNAK2 mutation + TMB-H (1)
ALK mutation + TMB-H (1)
ARID1A mutation + TMB-H (1)
ARID1B mutation + TMB-H (1)
ASPSCR1-TFE3 fusion +TMB-H (1)
BAP1 deletion + TMB-L + PD-L1 expression (1)
BRAF mutation + TMB-H (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
BRCA1 mutation + BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-L (1)
CD20 positive + TMB-L (1)
CD74-ROS1 fusion + TMB-H (1)
CDKN2A mutation + TMB-H (1)
EGFR L858R + TMB-H (1)
EGFR T790M + TMB-H (1)
EGFR mutation + ALK negative + TMB-H (1)
ELF3 mutation + TMB-L + MSI-L/dMMR (1)
EML4-ALK fusion + TMB-L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ERBB3 R135C + TMB-H (1)
HER-2 elevation + TMB-H (1)
HER-2 elevation + TMB-L (1)
HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)
HER-2 mutation + TMB-H (1)
HLA-E overexpression + TMB-L (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High IFNG gene signature + TMB-H (1)
IDH1 mutation + TMB-L (1)
IDH2 mutation + TMB-L (1)
KEAP1 mutation + TMB-H + PD-L1 overexpression (1)
KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)
KMT2C mutation + TMB-H (1)
KRAS A146 + TMB-H (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
MAP2K1 mutation + TMB-H (1)
MAP2K2 mutation + TMB-H (1)
MET mutation + TMB-H (1)
MGA mutation + TMB-L (1)
MGAM mutation + TMB-H (1)
MLH1 methylation + MSI-H/dMMR + TMB-H (1)
MSI-H/dMMR + TMB-H + POLE mutation (1)
NCR3LG1 underexpression + TMB-L (1)
NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)
NPAP1 mutation + TMB-H (1)
NTRK3 mutation + TMB-H (1)
PBRM1 mutation + TMB-H (1)
PBRM1 mutation + TMB-L + MSI-L/dMMR (1)
PD-L1 amplification + PD-L2 amplification + TMB-H (1)
PD-L1 negative + TMB-L (1)
PD-L1 negative + TMB-L + STING overexpression (1)
PD-L1 overexpression + TMB-H (1)
PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)
PD-L1 overexpression + TMB-L (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
POLE E790Q + ERBB2 amplification + TMB-H (1)
POLE P286R + TMB-H (1)
POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)
POLE mutation + PD-L1 negative + TMB-H (1)
PTCH1 1504-1G>T + TMB-H (1)
PTPN11 mutation + TMB-H (1)
PTPRD mutation + TMB-H (1)
RECQL5 mutation + TMB-H (1)
RET amplification + TMB-H + PD-L1 expression (1)
RYR1 mutation + TMB-H (1)
SMARCA4 mutation + TMB-H (1)
SMARCB1 mutation + TMB-H (1)
STK11 deletion + TMB-H (1)
STK11 mutation + TMB-H + PD-L1 overexpression (1)
TMB-H + ALK rearrangement (1)
TMB-H + CDKN2B mutation (1)
TMB-H + DDR (1)
TMB-H + KDM6A mutation (1)
TMB-H + LDH elevation (1)
TMB-H + MLL2 mutation (1)
TMB-H + MSH6 F1088fs (1)
TMB-H + PD-L1 expression + MSI-L/dMMR (1)
TMB-H + RB1 mutation + PD-L1 underexpression (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMB-H + TERT promoter mutation (1)
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)
TMB-L + LDH elevation (1)
TMB-L + PD-L1 underexpression (1)
TMB-L + RB1 mutation (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TPR mutation + TMB-H (1)
TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)
XIRP2 mutation + TMB-H (1)
ZNF479 mutation + TMB-H (1)
HR positive + HER-2 negative + TMB-L (0)
NOTCH4 mutation + PD-L1 expression + TMB-H (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
TMB-H (186)
MSI-H/dMMR + TMB-H (8)
TMB-H + PD-L1 overexpression (7)
MSI-H/dMMR + TMB-L (5)
BRCA1 mutation + TMB-H (3)
KMT2D mutation + TMB-H (3)
MLL3 mutation + TMB-H (3)
MSI-H/dMMR + TMB-H + PD-L1 negative (3)
PD-L1 expression + TMB-H (3)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)
HER-2 expression + TMB-H (2)
LRP1B mutation + TMB-H (2)
MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)
NCOR2-NTRK1 fusion + TMB-H (2)
PAPPA2 mutation + TMB-H (2)
PD-L1 expression + TMB-H + FANCA deletion (2)
STK11 mutation + TMB-H (2)
TMB-H + EGFR exon 19 deletion (2)
TMB-H + EGFR mutation (2)
TMB-H + HER-2 positive (2)
TMB-H + PD-L1 negative (2)
TMB-H + PD-L1 underexpression (2)
TMB-H + PIK3CA mutation (2)
TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)
TMB-L + PD-L1 expression (2)
AHNAK2 mutation + TMB-H (1)
ALK mutation + TMB-H (1)
ARID1A mutation + TMB-H (1)
ARID1B mutation + TMB-H (1)
ASPSCR1-TFE3 fusion +TMB-H (1)
BAP1 deletion + TMB-L + PD-L1 expression (1)
BRAF mutation + TMB-H (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
BRCA1 mutation + BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-L (1)
CD20 positive + TMB-L (1)
CD74-ROS1 fusion + TMB-H (1)
CDKN2A mutation + TMB-H (1)
EGFR L858R + TMB-H (1)
EGFR T790M + TMB-H (1)
EGFR mutation + ALK negative + TMB-H (1)
ELF3 mutation + TMB-L + MSI-L/dMMR (1)
EML4-ALK fusion + TMB-L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ERBB3 R135C + TMB-H (1)
HER-2 elevation + TMB-H (1)
HER-2 elevation + TMB-L (1)
HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)
HER-2 mutation + TMB-H (1)
HLA-E overexpression + TMB-L (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High IFNG gene signature + TMB-H (1)
IDH1 mutation + TMB-L (1)
IDH2 mutation + TMB-L (1)
KEAP1 mutation + TMB-H + PD-L1 overexpression (1)
KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)
KMT2C mutation + TMB-H (1)
KRAS A146 + TMB-H (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
MAP2K1 mutation + TMB-H (1)
MAP2K2 mutation + TMB-H (1)
MET mutation + TMB-H (1)
MGA mutation + TMB-L (1)
MGAM mutation + TMB-H (1)
MLH1 methylation + MSI-H/dMMR + TMB-H (1)
MSI-H/dMMR + TMB-H + POLE mutation (1)
NCR3LG1 underexpression + TMB-L (1)
NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)
NPAP1 mutation + TMB-H (1)
NTRK3 mutation + TMB-H (1)
PBRM1 mutation + TMB-H (1)
PBRM1 mutation + TMB-L + MSI-L/dMMR (1)
PD-L1 amplification + PD-L2 amplification + TMB-H (1)
PD-L1 negative + TMB-L (1)
PD-L1 negative + TMB-L + STING overexpression (1)
PD-L1 overexpression + TMB-H (1)
PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)
PD-L1 overexpression + TMB-L (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
POLE E790Q + ERBB2 amplification + TMB-H (1)
POLE P286R + TMB-H (1)
POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)
POLE mutation + PD-L1 negative + TMB-H (1)
PTCH1 1504-1G>T + TMB-H (1)
PTPN11 mutation + TMB-H (1)
PTPRD mutation + TMB-H (1)
RECQL5 mutation + TMB-H (1)
RET amplification + TMB-H + PD-L1 expression (1)
RYR1 mutation + TMB-H (1)
SMARCA4 mutation + TMB-H (1)
SMARCB1 mutation + TMB-H (1)
STK11 deletion + TMB-H (1)
STK11 mutation + TMB-H + PD-L1 overexpression (1)
TMB-H + ALK rearrangement (1)
TMB-H + CDKN2B mutation (1)
TMB-H + DDR (1)
TMB-H + KDM6A mutation (1)
TMB-H + LDH elevation (1)
TMB-H + MLL2 mutation (1)
TMB-H + MSH6 F1088fs (1)
TMB-H + PD-L1 expression + MSI-L/dMMR (1)
TMB-H + RB1 mutation + PD-L1 underexpression (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMB-H + TERT promoter mutation (1)
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)
TMB-L + LDH elevation (1)
TMB-L + PD-L1 underexpression (1)
TMB-L + RB1 mutation (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TPR mutation + TMB-H (1)
TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)
XIRP2 mutation + TMB-H (1)
ZNF479 mutation + TMB-H (1)
HR positive + HER-2 negative + TMB-L (0)
NOTCH4 mutation + PD-L1 expression + TMB-H (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
›
Associations
News
Trials
VERI cancer hierarchy
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TMB-L
Melanoma
TMB-L
Melanoma
trametinib + dabrafenib + PDR001
Sensitive: B - Late Trials
trametinib + dabrafenib + PDR001
Sensitive
:
B
trametinib + dabrafenib + PDR001
Sensitive: B - Late Trials
trametinib + dabrafenib + PDR001
Sensitive
:
B
TMB-L
Follicular Lymphoma
TMB-L
Follicular Lymphoma
rituximab
Sensitive: B - Late Trials
rituximab
Sensitive
:
B
rituximab
Sensitive: B - Late Trials
rituximab
Sensitive
:
B
TMB-L
Colorectal Cancer
TMB-L
Colorectal Cancer
durvalumab + tremelimumab
Sensitive: C3 – Early Trials
durvalumab + tremelimumab
Sensitive
:
C3
durvalumab + tremelimumab
Sensitive: C3 – Early Trials
durvalumab + tremelimumab
Sensitive
:
C3
TMB-L
Adrenal Cortex Carcinoma
TMB-L
Adrenal Cortex Carcinoma
mitotane
Sensitive: C3 – Early Trials
mitotane
Sensitive
:
C3
mitotane
Sensitive: C3 – Early Trials
mitotane
Sensitive
:
C3
TMB-L
Malignant Pleural Mesothelioma
TMB-L
Malignant Pleural Mesothelioma
PD1 inhibitor
Resistant: C3 – Early Trials
PD1 inhibitor
Resistant
:
C3
PD1 inhibitor
Resistant: C3 – Early Trials
PD1 inhibitor
Resistant
:
C3
TMB-L
Malignant Pleural Mesothelioma
TMB-L
Malignant Pleural Mesothelioma
PD-L1 inhibitor
Resistant: C3 – Early Trials
PD-L1 inhibitor
Resistant
:
C3
PD-L1 inhibitor
Resistant: C3 – Early Trials
PD-L1 inhibitor
Resistant
:
C3
TMB-L
Glioblastoma
TMB-L
Glioblastoma
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
TMB-L
Non Small Cell Lung Cancer
TMB-L
Non Small Cell Lung Cancer
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
atezolizumab
Sensitive: C3 – Early Trials
atezolizumab
Sensitive
:
C3
TMB-L
Non Small Cell Lung Cancer
TMB-L
Non Small Cell Lung Cancer
durvalumab + tremelimumab
Resistant: C3 – Early Trials
durvalumab + tremelimumab
Resistant
:
C3
durvalumab + tremelimumab
Resistant: C3 – Early Trials
durvalumab + tremelimumab
Resistant
:
C3
TMB-L
Pancreatic Cancer
TMB-L
Pancreatic Cancer
nivolumab + BMS-986227
Sensitive: C3 – Early Trials
nivolumab + BMS-986227
Sensitive
:
C3
nivolumab + BMS-986227
Sensitive: C3 – Early Trials
nivolumab + BMS-986227
Sensitive
:
C3
TMB-L
Lung Cancer
TMB-L
Lung Cancer
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
TMB-L
Gastric Cancer
TMB-L
Gastric Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
TMB-L
Mast Cell Leukemia
TMB-L
Mast Cell Leukemia
T-lymphocyte cell therapy
Sensitive: C3 – Early Trials
T-lymphocyte cell therapy
Sensitive
:
C3
T-lymphocyte cell therapy
Sensitive: C3 – Early Trials
T-lymphocyte cell therapy
Sensitive
:
C3
TMB-L
Diffuse Large B Cell Lymphoma
TMB-L
Diffuse Large B Cell Lymphoma
T-lymphocyte cell therapy
Sensitive: C3 – Early Trials
T-lymphocyte cell therapy
Sensitive
:
C3
T-lymphocyte cell therapy
Sensitive: C3 – Early Trials
T-lymphocyte cell therapy
Sensitive
:
C3
TMB-L
Non Small Cell Lung Cancer
TMB-L
Non Small Cell Lung Cancer
nivolumab + HS-110
Sensitive: C3 – Early Trials
nivolumab + HS-110
Sensitive
:
C3
nivolumab + HS-110
Sensitive: C3 – Early Trials
nivolumab + HS-110
Sensitive
:
C3
TMB-L
Neuroendocrine Tumor
TMB-L
Neuroendocrine Tumor
toripalimab-tpzi
Sensitive: C3 – Early Trials
toripalimab-tpzi
Sensitive
:
C3
toripalimab-tpzi
Sensitive: C3 – Early Trials
toripalimab-tpzi
Sensitive
:
C3
TMB-L
Colorectal Cancer
TMB-L
Colorectal Cancer
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
TMB-L
Non Small Cell Lung Cancer
TMB-L
Non Small Cell Lung Cancer
palbociclib + avelumab + axitinib
Sensitive: C3 – Early Trials
palbociclib + avelumab + axitinib
Sensitive
:
C3
palbociclib + avelumab + axitinib
Sensitive: C3 – Early Trials
palbociclib + avelumab + axitinib
Sensitive
:
C3
TMB-L
Triple Negative Breast Cancer
TMB-L
Triple Negative Breast Cancer
durvalumab
Sensitive: C3 – Early Trials
durvalumab
Sensitive
:
C3
durvalumab
Sensitive: C3 – Early Trials
durvalumab
Sensitive
:
C3
TMB-L
Lymphoma
TMB-L
Lymphoma
ibrutinib
Sensitive: C3 – Early Trials
ibrutinib
Sensitive
:
C3
ibrutinib
Sensitive: C3 – Early Trials
ibrutinib
Sensitive
:
C3
TMB-L
Non Small Cell Lung Cancer
TMB-L
Non Small Cell Lung Cancer
avelumab + axitinib
Sensitive: C3 – Early Trials
avelumab + axitinib
Sensitive
:
C3
avelumab + axitinib
Sensitive: C3 – Early Trials
avelumab + axitinib
Sensitive
:
C3
TMB-L
Breast Cancer
TMB-L
Breast Cancer
nivolumab + COM701
Sensitive: C3 – Early Trials
nivolumab + COM701
Sensitive
:
C3
nivolumab + COM701
Sensitive: C3 – Early Trials
nivolumab + COM701
Sensitive
:
C3
TMB-L
Triple Negative Breast Cancer
TMB-L
Triple Negative Breast Cancer
anlotinib + APL-502
Sensitive: C3 – Early Trials
anlotinib + APL-502
Sensitive
:
C3
anlotinib + APL-502
Sensitive: C3 – Early Trials
anlotinib + APL-502
Sensitive
:
C3
TMB-L
Pancreatic Ductal Adenocarcinoma
TMB-L
Pancreatic Ductal Adenocarcinoma
trametinib + Torin1
Sensitive: D – Preclinical
trametinib + Torin1
Sensitive
:
D
trametinib + Torin1
Sensitive: D – Preclinical
trametinib + Torin1
Sensitive
:
D
TMB-L
Gastric Cancer
TMB-L
Gastric Cancer
olaparib
Resistant: D – Preclinical
olaparib
Resistant
:
D
olaparib
Resistant: D – Preclinical
olaparib
Resistant
:
D
^
^
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