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BIOMARKER:
TMB-H
i
Other names:
TMB | Tumor Mutational Burden
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Related biomarkers:
Expression
Others
‹
TMB-L (25)
MSI-H/dMMR + TMB-H (8)
TMB-H + PD-L1 overexpression (7)
MSI-H/dMMR + TMB-L (5)
BRCA1 mutation + TMB-H (3)
KMT2D mutation + TMB-H (3)
MLL3 mutation + TMB-H (3)
MSI-H/dMMR + TMB-H + PD-L1 negative (3)
PD-L1 expression + TMB-H (3)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)
HER-2 expression + TMB-H (2)
LRP1B mutation + TMB-H (2)
MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)
NCOR2-NTRK1 fusion + TMB-H (2)
PAPPA2 mutation + TMB-H (2)
PD-L1 expression + TMB-H + FANCA deletion (2)
STK11 mutation + TMB-H (2)
TMB-H + EGFR exon 19 deletion (2)
TMB-H + EGFR mutation (2)
TMB-H + HER-2 positive (2)
TMB-H + PD-L1 negative (2)
TMB-H + PD-L1 underexpression (2)
TMB-H + PIK3CA mutation (2)
TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)
TMB-L + PD-L1 expression (2)
AHNAK2 mutation + TMB-H (1)
ALK mutation + TMB-H (1)
ARID1A mutation + TMB-H (1)
ARID1B mutation + TMB-H (1)
ASPSCR1-TFE3 fusion +TMB-H (1)
BAP1 deletion + TMB-L + PD-L1 expression (1)
BRAF mutation + TMB-H (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
BRCA1 mutation + BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-L (1)
CD20 positive + TMB-L (1)
CD74-ROS1 fusion + TMB-H (1)
CDKN2A mutation + TMB-H (1)
EGFR L858R + TMB-H (1)
EGFR T790M + TMB-H (1)
EGFR mutation + ALK negative + TMB-H (1)
ELF3 mutation + TMB-L + MSI-L/dMMR (1)
EML4-ALK fusion + TMB-L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ERBB3 R135C + TMB-H (1)
HER-2 elevation + TMB-H (1)
HER-2 elevation + TMB-L (1)
HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)
HER-2 mutation + TMB-H (1)
HLA-E overexpression + TMB-L (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High IFNG gene signature + TMB-H (1)
IDH1 mutation + TMB-L (1)
IDH2 mutation + TMB-L (1)
KEAP1 mutation + TMB-H + PD-L1 overexpression (1)
KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)
KMT2C mutation + TMB-H (1)
KRAS A146 + TMB-H (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
MAP2K1 mutation + TMB-H (1)
MAP2K2 mutation + TMB-H (1)
MET mutation + TMB-H (1)
MGA mutation + TMB-L (1)
MGAM mutation + TMB-H (1)
MLH1 methylation + MSI-H/dMMR + TMB-H (1)
MSI-H/dMMR + TMB-H + POLE mutation (1)
NCR3LG1 underexpression + TMB-L (1)
NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)
NPAP1 mutation + TMB-H (1)
NTRK3 mutation + TMB-H (1)
PBRM1 mutation + TMB-H (1)
PBRM1 mutation + TMB-L + MSI-L/dMMR (1)
PD-L1 amplification + PD-L2 amplification + TMB-H (1)
PD-L1 negative + TMB-L (1)
PD-L1 negative + TMB-L + STING overexpression (1)
PD-L1 overexpression + TMB-H (1)
PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)
PD-L1 overexpression + TMB-L (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
POLE E790Q + ERBB2 amplification + TMB-H (1)
POLE P286R + TMB-H (1)
POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)
POLE mutation + PD-L1 negative + TMB-H (1)
PTCH1 1504-1G>T + TMB-H (1)
PTPN11 mutation + TMB-H (1)
PTPRD mutation + TMB-H (1)
RECQL5 mutation + TMB-H (1)
RET amplification + TMB-H + PD-L1 expression (1)
RYR1 mutation + TMB-H (1)
SMARCA4 mutation + TMB-H (1)
SMARCB1 mutation + TMB-H (1)
STK11 deletion + TMB-H (1)
STK11 mutation + TMB-H + PD-L1 overexpression (1)
TMB-H + ALK rearrangement (1)
TMB-H + CDKN2B mutation (1)
TMB-H + DDR (1)
TMB-H + KDM6A mutation (1)
TMB-H + LDH elevation (1)
TMB-H + MLL2 mutation (1)
TMB-H + MSH6 F1088fs (1)
TMB-H + PD-L1 expression + MSI-L/dMMR (1)
TMB-H + RB1 mutation + PD-L1 underexpression (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMB-H + TERT promoter mutation (1)
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)
TMB-L + LDH elevation (1)
TMB-L + PD-L1 underexpression (1)
TMB-L + RB1 mutation (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TPR mutation + TMB-H (1)
TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)
XIRP2 mutation + TMB-H (1)
ZNF479 mutation + TMB-H (1)
HR positive + HER-2 negative + TMB-L (0)
NOTCH4 mutation + PD-L1 expression + TMB-H (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
TMB-L (25)
MSI-H/dMMR + TMB-H (8)
TMB-H + PD-L1 overexpression (7)
MSI-H/dMMR + TMB-L (5)
BRCA1 mutation + TMB-H (3)
KMT2D mutation + TMB-H (3)
MLL3 mutation + TMB-H (3)
MSI-H/dMMR + TMB-H + PD-L1 negative (3)
PD-L1 expression + TMB-H (3)
EGFR C797S + EGFR T790M + EGFR exon 19 deletion + TMB-L (2)
HER-2 expression + TMB-H (2)
LRP1B mutation + TMB-H (2)
MSI-H/dMMR + TMB-H + PD-L1 overexpression (2)
NCOR2-NTRK1 fusion + TMB-H (2)
PAPPA2 mutation + TMB-H (2)
PD-L1 expression + TMB-H + FANCA deletion (2)
STK11 mutation + TMB-H (2)
TMB-H + EGFR exon 19 deletion (2)
TMB-H + EGFR mutation (2)
TMB-H + HER-2 positive (2)
TMB-H + PD-L1 negative (2)
TMB-H + PD-L1 underexpression (2)
TMB-H + PIK3CA mutation (2)
TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)
TMB-L + PD-L1 expression (2)
AHNAK2 mutation + TMB-H (1)
ALK mutation + TMB-H (1)
ARID1A mutation + TMB-H (1)
ARID1B mutation + TMB-H (1)
ASPSCR1-TFE3 fusion +TMB-H (1)
BAP1 deletion + TMB-L + PD-L1 expression (1)
BRAF mutation + TMB-H (1)
BRAF mutation + TMB-L + MSI-L/dMMR (1)
BRCA1 mutation + BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-H (1)
BRCA2 mutation + TMB-L (1)
CD20 positive + TMB-L (1)
CD74-ROS1 fusion + TMB-H (1)
CDKN2A mutation + TMB-H (1)
EGFR L858R + TMB-H (1)
EGFR T790M + TMB-H (1)
EGFR mutation + ALK negative + TMB-H (1)
ELF3 mutation + TMB-L + MSI-L/dMMR (1)
EML4-ALK fusion + TMB-L (1)
ER positive + MLH1 1835del3 + MSI-H/dMMR + TMB-H (1)
ERBB3 R135C + TMB-H (1)
HER-2 elevation + TMB-H (1)
HER-2 elevation + TMB-L (1)
HER-2 exon 20 insertion + TMB-L + PD-L1 negative (1)
HER-2 mutation + TMB-H (1)
HLA-E overexpression + TMB-L (1)
HR positive + TMB-H (1)
HR positive + TMB-L (1)
High IFNG gene signature + TMB-H (1)
IDH1 mutation + TMB-L (1)
IDH2 mutation + TMB-L (1)
KEAP1 mutation + TMB-H + PD-L1 overexpression (1)
KMT2C mutation + BCOR mutation + KDM5C mutation + TMB-H (1)
KMT2C mutation + TMB-H (1)
KRAS A146 + TMB-H (1)
KRAS G12D + HER-2 amplification + TMB-H (1)
MAP2K1 mutation + TMB-H (1)
MAP2K2 mutation + TMB-H (1)
MET mutation + TMB-H (1)
MGA mutation + TMB-L (1)
MGAM mutation + TMB-H (1)
MLH1 methylation + MSI-H/dMMR + TMB-H (1)
MSI-H/dMMR + TMB-H + POLE mutation (1)
NCR3LG1 underexpression + TMB-L (1)
NOTCH1 mutation + TMB-L + MSI-L/dMMR (1)
NPAP1 mutation + TMB-H (1)
NTRK3 mutation + TMB-H (1)
PBRM1 mutation + TMB-H (1)
PBRM1 mutation + TMB-L + MSI-L/dMMR (1)
PD-L1 amplification + PD-L2 amplification + TMB-H (1)
PD-L1 negative + TMB-L (1)
PD-L1 negative + TMB-L + STING overexpression (1)
PD-L1 overexpression + TMB-H (1)
PD-L1 overexpression + TMB-H + ARID1A F2141fs*59 (1)
PD-L1 overexpression + TMB-L (1)
PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)
POLE E790Q + ERBB2 amplification + TMB-H (1)
POLE P286R + TMB-H (1)
POLE V1368M + ERBB3 G1271S + TNFAIP3 P714A + PRKN I69T + TSC2 G1399R + TMB-L (1)
POLE mutation + PD-L1 negative + TMB-H (1)
PTCH1 1504-1G>T + TMB-H (1)
PTPN11 mutation + TMB-H (1)
PTPRD mutation + TMB-H (1)
RECQL5 mutation + TMB-H (1)
RET amplification + TMB-H + PD-L1 expression (1)
RYR1 mutation + TMB-H (1)
SMARCA4 mutation + TMB-H (1)
SMARCB1 mutation + TMB-H (1)
STK11 deletion + TMB-H (1)
STK11 mutation + TMB-H + PD-L1 overexpression (1)
TMB-H + ALK rearrangement (1)
TMB-H + CDKN2B mutation (1)
TMB-H + DDR (1)
TMB-H + KDM6A mutation (1)
TMB-H + LDH elevation (1)
TMB-H + MLL2 mutation (1)
TMB-H + MSH6 F1088fs (1)
TMB-H + PD-L1 expression + MSI-L/dMMR (1)
TMB-H + RB1 mutation + PD-L1 underexpression (1)
TMB-H + RB1 L518fs*6 + ERCC4 R799W + TP53 C124* (1)
TMB-H + TERT promoter mutation (1)
TMB-L + ARID1A deletion + CDKN2A deletion + CDKN2B deletion + MTAP deletion + PIK3R1 N564D + NBN P81fs*23 (1)
TMB-L + LDH elevation (1)
TMB-L + PD-L1 underexpression (1)
TMB-L + RB1 mutation (1)
TP53 S12F + KRAS G12D + TMB-L (1)
TP53 mutation + FANCM mutation + TMB-H (1)
TP53 mutation + LRP1B mutation + TMB-H (1)
TP53 mutation + TMB-H + PD-L1 overexpression (1)
TPR mutation + TMB-H (1)
TTF1 expression + NAPSA expression + PD-L1 expression + TMB-H (1)
XIRP2 mutation + TMB-H (1)
ZNF479 mutation + TMB-H (1)
HR positive + HER-2 negative + TMB-L (0)
NOTCH4 mutation + PD-L1 expression + TMB-H (0)
PIK3CA mutation + TMB-L + MSI-L/dMMR (0)
›
Related tests:
FoundationOne® CDx (110)
FoundationOne® CDx (110)
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
TMB-H
Solid Tumor
TMB-H
Solid Tumor
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
pembrolizumab
Sensitive: A1 - Approval
pembrolizumab
Sensitive
:
A1
TMB-H
Peritoneal Cancer
TMB-H
Peritoneal Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Gastric Cancer
TMB-H
Gastric Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Testicular Seminoma
TMB-H
Testicular Seminoma
Sensitive: A2 - Guideline
Sensitive
:
A2
Sensitive: A2 - Guideline
Sensitive
:
A2
TMB-H
Sarcoma
TMB-H
Sarcoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Thyroid Gland Hurthle Cell Carcinoma
TMB-H
Thyroid Gland Hurthle Cell Carcinoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Chordoma
TMB-H
Chordoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Germ Cell Tumors
TMB-H
Germ Cell Tumors
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Thyroid Gland Follicular Carcinoma
TMB-H
Thyroid Gland Follicular Carcinoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Thyroid Gland Medullary Carcinoma
TMB-H
Thyroid Gland Medullary Carcinoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Endometrial Cancer
TMB-H
Endometrial Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Cervical Cancer
TMB-H
Cervical Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Thyroid Gland Papillary Carcinoma
TMB-H
Thyroid Gland Papillary Carcinoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Non Small Cell Lung Cancer
TMB-H
Non Small Cell Lung Cancer
nivolumab + ipilimumab
Sensitive: A2 - Guideline
nivolumab + ipilimumab
Sensitive
:
A2
nivolumab + ipilimumab
Sensitive: A2 - Guideline
nivolumab + ipilimumab
Sensitive
:
A2
TMB-H
Breast Cancer
TMB-H
Breast Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Melanoma
TMB-H
Melanoma
nivolumab + ipilimumab
Sensitive: A2 - Guideline
nivolumab + ipilimumab
Sensitive
:
A2
nivolumab + ipilimumab
Sensitive: A2 - Guideline
nivolumab + ipilimumab
Sensitive
:
A2
TMB-H
Solid Tumor
TMB-H
Solid Tumor
nivolumab + ipilimumab
Sensitive: A2 - Guideline
nivolumab + ipilimumab
Sensitive
:
A2
nivolumab + ipilimumab
Sensitive: A2 - Guideline
nivolumab + ipilimumab
Sensitive
:
A2
TMB-H
Ewing Sarcoma
TMB-H
Ewing Sarcoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Osteosarcoma
TMB-H
Osteosarcoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Penile Cancer
TMB-H
Penile Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Thyroid Gland Anaplastic Carcinoma
TMB-H
Thyroid Gland Anaplastic Carcinoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Gastroesophageal Junction Adenocarcinoma
TMB-H
Gastroesophageal Junction Adenocarcinoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Esophageal Cancer
TMB-H
Esophageal Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Pancreatic Adenocarcinoma
TMB-H
Pancreatic Adenocarcinoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Ovarian Cancer
TMB-H
Ovarian Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Fallopian Tube Cancer
TMB-H
Fallopian Tube Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Neuroendocrine Tumor
TMB-H
Neuroendocrine Tumor
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Testicular Cancer
TMB-H
Testicular Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Vulvar Cancer
TMB-H
Vulvar Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Prostate Cancer
TMB-H
Prostate Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Nasopharyngeal Carcinoma
TMB-H
Nasopharyngeal Carcinoma
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
TMB-H
Biliary Tract Cancer
TMB-H
Biliary Tract Cancer
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
pembrolizumab
Sensitive: A2 - Guideline
pembrolizumab
Sensitive
:
A2
^
^
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