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GENE:

TIMP1 (Tissue inhibitor of metalloproteinases 1)

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TIMP1 expression	Renal Cell Carcinoma	TIMP1 expression	Renal Cell Carcinoma	lenvatinib Sensitive: C3 – Early Trials lenvatinib Sensitive : C3	lenvatinib Sensitive: C3 – Early Trials lenvatinib Sensitive : C3
TIMP1-L	Cholangiocarcinoma	TIMP1-L	Cholangiocarcinoma	cabozantinib tablet Sensitive: C3 – Early Trials cabozantinib tablet Sensitive : C3	cabozantinib tablet Sensitive: C3 – Early Trials cabozantinib tablet Sensitive : C3
TIMP1 overexpression	Ovarian Cancer	TIMP1 overexpression	Ovarian Cancer	bevacizumab Resistant: C3 – Early Trials bevacizumab Resistant : C3	bevacizumab Resistant: C3 – Early Trials bevacizumab Resistant : C3
TIMP1 overexpression	Breast Cancer	TIMP1 overexpression	Breast Cancer	fulvestrant Resistant: D – Preclinical fulvestrant Resistant : D	fulvestrant Resistant: D – Preclinical fulvestrant Resistant : D