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Association details:
Evidence:
Evidence Level:
Resistant: D – Preclinical
New
Source:
Title:

TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression

Excerpt:
Cells with high expression of TIMP1 versus low TIMP1 displayed significantly reduced sensitivity to the antiestrogen fulvestrant (ICI 182,780, Faslodex®), while TIMP1 levels did not influence the sensitivity to 4-hydroxytamoxifen.
DOI:
10.1007/s13277-013-0969-7