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BIOMARKER:
TERT mutation
i
Other names:
TERT, Telomerase Reverse Transcriptase, Telomerase-Associated Protein 2, Telomerase Catalytic Subunit, HEST2, EST2, TCS1, TP2, TRT, PFBMFT1, DKCA2, DKCB4, CMM9, HTR
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Entrez ID:
7015
Related biomarkers:
Expression
Mutation
CNA
Others
‹
BRAF V600E + TERT mutation (3)
TERT promoter mutation (3)
TERT mutation + BRAF V600E (3)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
BRAF mutation + TERT −124C>T (1)
BRAF mutation + TERT −138CC>TT (1)
BRAF mutation + TERT −139CC>TT (1)
BRAF mutation + TERT −146C>T (1)
PIK3CA mutation + TERT promoter mutation (1)
TERT 124C>T (1)
TERT mutation + ERBB4 mutation (1)
TERT mutation + TP53 mutation (1)
TERT promoter mutation + BRAF V600 (1)
TERT rearrangement (1)
BRAF V600E + TERT mutation (0)
BRAF V600E + TERT mutation (3)
TERT promoter mutation (3)
TERT mutation + BRAF V600E (3)
BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)
BRAF mutation + TERT −124C>T (1)
BRAF mutation + TERT −138CC>TT (1)
BRAF mutation + TERT −139CC>TT (1)
BRAF mutation + TERT −146C>T (1)
PIK3CA mutation + TERT promoter mutation (1)
TERT 124C>T (1)
TERT mutation + ERBB4 mutation (1)
TERT mutation + TP53 mutation (1)
TERT promoter mutation + BRAF V600 (1)
TERT rearrangement (1)
BRAF V600E + TERT mutation (0)
›
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Trials
VERI cancer hierarchy
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TERT mutation
Solid Tumor
TERT mutation
Solid Tumor
Immunotherapy
Sensitive: C2 – Inclusion Criteria
Immunotherapy
Sensitive
:
C2
Immunotherapy
Sensitive: C2 – Inclusion Criteria
Immunotherapy
Sensitive
:
C2
TERT mutation
Hepatocellular Cancer
TERT mutation
Hepatocellular Cancer
bevacizumab + atezolizumab
Resistant: C3 – Early Trials
bevacizumab + atezolizumab
Resistant
:
C3
bevacizumab + atezolizumab
Resistant: C3 – Early Trials
bevacizumab + atezolizumab
Resistant
:
C3
TERT mutation
Squamous Cell Carcinoma of Head and Neck
TERT mutation
Squamous Cell Carcinoma of Head and Neck
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
PD1 inhibitor
Sensitive: C3 – Early Trials
PD1 inhibitor
Sensitive
:
C3
TERT mutation
Soft Tissue Sarcoma
TERT mutation
Soft Tissue Sarcoma
eribulin mesylate
Sensitive: C3 – Early Trials
eribulin mesylate
Sensitive
:
C3
eribulin mesylate
Sensitive: C3 – Early Trials
eribulin mesylate
Sensitive
:
C3
TERT mutation
Solid Tumor
TERT mutation
Solid Tumor
AST-487
Sensitive: D – Preclinical
AST-487
Sensitive
:
D
AST-487
Sensitive: D – Preclinical
AST-487
Sensitive
:
D
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