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DRUG CLASS:

SOS1 inhibitor

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SOS1 inhibitor

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KRAS mutation	Pancreatic Cancer	KRAS mutation	Pancreatic Cancer	BI-3406 Sensitive: D – Preclinical BI-3406 Sensitive : D	BI-3406 Sensitive: D – Preclinical BI-3406 Sensitive : D
KRAS mutation	Non Small Cell Lung Cancer	KRAS mutation	Non Small Cell Lung Cancer	BI-3406 + MEK inhibitor Sensitive: D – Preclinical BI-3406 + MEK inhibitor Sensitive : D	BI-3406 + MEK inhibitor Sensitive: D – Preclinical BI-3406 + MEK inhibitor Sensitive : D
KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	trametinib + BI 1701963 Sensitive: D – Preclinical trametinib + BI 1701963 Sensitive : D	trametinib + BI 1701963 Sensitive: D – Preclinical trametinib + BI 1701963 Sensitive : D
KRAS mutation	Colorectal Cancer	KRAS mutation	Colorectal Cancer	BI-3406 + MEK inhibitor Sensitive: D – Preclinical BI-3406 + MEK inhibitor Sensitive : D	BI-3406 + MEK inhibitor Sensitive: D – Preclinical BI-3406 + MEK inhibitor Sensitive : D
KRAS Y96S	Solid Tumor	KRAS Y96S	Solid Tumor	trametinib + BI-3406 Sensitive: D – Preclinical trametinib + BI-3406 Sensitive : D	trametinib + BI-3406 Sensitive: D – Preclinical trametinib + BI-3406 Sensitive : D
KRAS Y96D	Solid Tumor	KRAS Y96D	Solid Tumor	trametinib + BI-3406 Sensitive: D – Preclinical trametinib + BI-3406 Sensitive : D	trametinib + BI-3406 Sensitive: D – Preclinical trametinib + BI-3406 Sensitive : D
KRAS G12D	Pancreatic Ductal Adenocarcinoma	KRAS G12D	Pancreatic Ductal Adenocarcinoma	trametinib + BI-3406 Sensitive: D – Preclinical trametinib + BI-3406 Sensitive : D	trametinib + BI-3406 Sensitive: D – Preclinical trametinib + BI-3406 Sensitive : D
KRAS mutation	Lung Cancer	KRAS mutation	Lung Cancer	RGT-018 Sensitive: D – Preclinical RGT-018 Sensitive : D	RGT-018 Sensitive: D – Preclinical RGT-018 Sensitive : D
KRAS mutation	Pancreatic Cancer	KRAS mutation	Pancreatic Cancer	RGT-018 Sensitive: D – Preclinical RGT-018 Sensitive : D	RGT-018 Sensitive: D – Preclinical RGT-018 Sensitive : D
KRAS G12D	Endometrial Cancer	KRAS G12D	Endometrial Cancer	trametinib + BI-3406 Sensitive: D – Preclinical trametinib + BI-3406 Sensitive : D	trametinib + BI-3406 Sensitive: D – Preclinical trametinib + BI-3406 Sensitive : D