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Association details:
| Biomarker: | KRAS G12D |
|---|---|
| Cancer: | Endometrial Cancer |
| Drug: | Mekinist (trametinib) (MEK inhibitor) + BI-3406 (SOS1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1083 / 27 - MEKi and SOS1i as a combination treatment option for KRAS mutant endometrial cancer
Published date:
03/15/2023
Excerpt:
...we treated preclinical models of EC with a combination of clinically relevant doses of a MEKi (trametinib) and BI-3406, a potent and selective orally bioavailable SOS1 inhibitor....In vivo, the combination of MEKi with SOS1i synergistically decreased tumor growth in two KRAS G12D mutant orthotopic patient-derived xenograft models of EC.
