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    Association details:
    Biomarker:SF3B1 mutation
    Cancer:Chronic Myeloid Leukemia
    Drug:VE-821 (ATR inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    ASH 2019
    Title:

    The SF3B1 K700E Mutation Induces R-Loop Accumulation and Associated DNA Damage

    Published date:
    11/06/2019
    Excerpt:
    SF3B1 mutant K562 cells showed preferential sensitivity towards VE-821 compared to SF3B1 WT K562 cells.