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BIOMARKER:
ROS1 mutation
i
Other names:
ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1, C-Ros Oncogene 1 Receptor Tyrosine Kinase, Proto-Oncogene Tyrosine-Protein Kinase ROS, Proto-Oncogene C-Ros-1, MCF3, ROS, V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian), ROS Proto-Oncogene 1 Receptor Tyrosine Kinase, Transmembrane Tyrosine-Specific Protein Kinase, Receptor Tyrosine Kinase C-Ros Oncogene 1, C-Ros Receptor Tyrosine Kinase, Proto-oncogene C-Ros, C-Ros-1
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Entrez ID:
6098
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
ROS1 rearrangement (15)
ROS1 G2032R (8)
ROS1 wild-type (7)
ROS1 L2086F (5)
ROS1 D2033N (3)
ROS1 F2004C (3)
CD74-ROS1 rearrangement (2)
ROS1 G2032R + ROS1 L2086F (2)
ROS1 S1986F + ROS1 G2032R + ROS1 L2086F (2)
CD74-ROS1 rearrangement + ROS1 F2004V + ROS1 L2086F (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
MAN1A1-ROS1 rearrangement (1)
ROS1 G2032K (1)
ROS1 L2155S (1)
ROS1 S1986F (1)
ROS1 S1986Y + ROS1 S1986F (1)
ROS1 rearrangement + BRAF V600E (1)
TFG-ROS1 rearrangement (1)
ROS rearrangement + MET D1246N (0)
ROS1 S1986Y (0)
ROS1 rearrangement (15)
ROS1 G2032R (8)
ROS1 wild-type (7)
ROS1 L2086F (5)
ROS1 D2033N (3)
ROS1 F2004C (3)
CD74-ROS1 rearrangement (2)
ROS1 G2032R + ROS1 L2086F (2)
ROS1 S1986F + ROS1 G2032R + ROS1 L2086F (2)
CD74-ROS1 rearrangement + ROS1 F2004V + ROS1 L2086F (1)
EGFR wild-type + ALK wild-type + ROS1 wild-type (1)
MAN1A1-ROS1 rearrangement (1)
ROS1 G2032K (1)
ROS1 L2155S (1)
ROS1 S1986F (1)
ROS1 S1986Y + ROS1 S1986F (1)
ROS1 rearrangement + BRAF V600E (1)
TFG-ROS1 rearrangement (1)
ROS rearrangement + MET D1246N (0)
ROS1 S1986Y (0)
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Associations
News
Trials
VERI cancer hierarchy
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ROS1 mutation
Non Small Cell Lung Cancer
ROS1 mutation
Non Small Cell Lung Cancer
VEGFR-2 inhibitor
Sensitive: C3 – Early Trials
VEGFR-2 inhibitor
Sensitive
:
C3
VEGFR-2 inhibitor
Sensitive: C3 – Early Trials
VEGFR-2 inhibitor
Sensitive
:
C3
ROS1 mutation
Non Small Cell Lung Cancer
ROS1 mutation
Non Small Cell Lung Cancer
entrectinib
Resistant: C3 – Early Trials
entrectinib
Resistant
:
C3
entrectinib
Resistant: C3 – Early Trials
entrectinib
Resistant
:
C3
ROS1 mutation
Solid Tumor
ROS1 mutation
Solid Tumor
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
Immunotherapy
Sensitive: C3 – Early Trials
Immunotherapy
Sensitive
:
C3
ROS1 mutation
Non Small Cell Lung Cancer
ROS1 mutation
Non Small Cell Lung Cancer
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
Tyrosine kinase inhibitor
Sensitive: C3 – Early Trials
Tyrosine kinase inhibitor
Sensitive
:
C3
ROS1 mutation
Head and Neck Cancer
ROS1 mutation
Head and Neck Cancer
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
Immunotherapy
Resistant: C3 – Early Trials
Immunotherapy
Resistant
:
C3
ROS1 mutation
Non Small Cell Lung Cancer
ROS1 mutation
Non Small Cell Lung Cancer
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
crizotinib
Sensitive: C4 – Case Studies
crizotinib
Sensitive
:
C4
ROS1 mutation
Non Small Cell Lung Cancer
ROS1 mutation
Non Small Cell Lung Cancer
repotrectinib
Sensitive: D – Preclinical
repotrectinib
Sensitive
:
D
repotrectinib
Sensitive: D – Preclinical
repotrectinib
Sensitive
:
D
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