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    BIOMARKER:

    PTEN underexpression

    i
    Other names: PTEN, Phosphatase and tensin homolog, Mutated In Multiple Advanced Cancers 1, Phosphatase And Tensin Homolog, Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase And Dual-Specificity Protein Phosphatase PTEN, MMAC1, TEP1, MMAC1 Phosphatase And Tensin Homolog Deleted On Chromosome 10, Mitochondrial Phosphatase And Tensin Protein Alpha, Phosphatase And Tensin-Like Protein, Protein Tyrosine Phosphatase, Mitochondrial PTENalpha, PTENbeta, PTEN1, CWS1, GLM2, MHAM
    Entrez ID:
    5728
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others

    Associations

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    Trials
    PTEN underexpression
    CLL
    ibrutinib
    Resistant: C3 – Early Trials
    PTEN underexpression
    Hormone Receptor Positive Breast Cancer
    tamoxifen
    Resistant: C3 – Early Trials
    PTEN underexpression
    Pancreatic Cancer
    trametinib + dabrafenib
    Resistant: C4 – Case Studies
    PTEN underexpression
    CML
    imatinib
    Sensitive: D – Preclinical
    PTEN underexpression
    Breast Cancer
    AZD1775
    Sensitive: D – Preclinical
    PTEN underexpression
    Prostate Cancer
    copanlisib + darolutamide
    Sensitive: D – Preclinical