^
Association details:
| Biomarker: | PTEN underexpression |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | adavosertib (AZD1775) (WEE1 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer
Published date:
07/06/2020
Excerpt:
PTEN low' BLBCs were highly sensitive to AZD1775 and failed to recover following removal of AZD1775, while 'PTEN high' BLBCs recovered.
DOI:
10.7554/eLife.57894
