^
Association details:
Biomarker:PTEN mutation
Cancer:Endometrial Cancer
Drug:pictilisib (GDC-0941) (PI3K inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

PI3K pathway dependencies in endometrioid endometrial cancer cell lines

Excerpt:
EEC cell lines harboring PIK3CA and PTEN mutations were selectively sensitive to the pan-class I PI3K inhibitor GDC-0941 and allosteric mTOR inhibitor Temsirolimus, respectively....Targeted pan-PI3K and mTOR inhibition in EEC cells may be most effective in PIK3CA-mutant and PTEN-mutant tumors, respectively...
DOI:
10.1158/1078-0432.CCR-12-3815