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Association details:
| Biomarker: | PTEN deletion |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | pictilisib (GDC-0941) (PI3K inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models
Excerpt:
...generally greater sensitivity to the selective PI3K inhibitor GDC-0941 in epithelial compared with mesenchymal cell lines (P < 0.04, Fig. 4A); 4 of the 6 least sensitive epithelial cell lines harbored RAS mutations, whereas the 2 most sensitive mesenchymal lines harbored PIK3CA mutations (Fig. 4A and B). In addition, cell lines with receptor tyrosine kinase (RTK), PIK3CA alterations, or PTEN loss were significantly more sensitive to GDC-0941 as a class...
DOI:
10.1158/1078-0432.CCR-12-2347
