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Association details:
Biomarker:PTEN deletion
Cancer:Melanoma
Drug:Tafinlar (dabrafenib) (BRAF inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: C4 – Case Studies
New
Title:

The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma

Excerpt:
The resistant tumor from Patient 36 harbored a PTEN deletion (Fig. 6A), although the pre-treatment tumor was unavailable for this case.
DOI:
10.1158/2159-8290.CD-13-0617