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Association details:
| Biomarker: | PTEN deletion |
|---|---|
| Cancer: | Melanoma |
| Drug: | Tafinlar (dabrafenib) (BRAF inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma
Excerpt:
The resistant tumor from Patient 36 harbored a PTEN deletion (Fig. 6A), although the pre-treatment tumor was unavailable for this case.
DOI:
10.1158/2159-8290.CD-13-0617
